Book Hotels in Dona Ana, NM
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Top Dona Ana hotels

Drury Inn & Suites Las Cruces
1631 Hickory Loop Las Cruces NM
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from May 31 to Jun 1
$123 total
May 31 - Jun 1
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Great experience! Helpful staff that made our stay in las cruces great especially after a negative experience at another hotel."
Reviewed on May 18, 2026

Hotel Encanto de Las Cruces
705 S Telshor Blvd Las Cruces NM
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $154 total per night from May 20 to May 21
$154 total
May 20 - May 21
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling for business? Take advantage of the 24-hour business center, ...
"This property has Las Cruces flair, was extremely clean, and the staff went above and beyond to make our stay enjoyable! The restaurant had indoor and outdoor patio seating where we enjoyed a live band, too!!! The pool and hot tub snuggled into the property ‘gardens’ made it feel more resort-like ..."
Reviewed on May 19, 2026

Comfort Suites Las Cruces I-25 North
236 N Telshor Blvd. Las Cruces NM
Fully refundable
$124 nightly
The price is $143 total per night from Jun 14 to Jun 15
$143 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"Second time staying at this hotel. Room was nice and roomy, clean and comfortable. Staff was nice and polite."
Reviewed on May 18, 2026

Best Western Mission Inn
1765 S Main St Las Cruces NM
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $99 total per night from May 21 to May 22
$99 total
May 21 - May 22
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
"The pool was closed and the parking lot was nothing but potholes. There was popcorn all over the couch."
Reviewed on May 19, 2026

Days Inn by Wyndham Las Cruces
755 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $57 total per night from Jun 1 to Jun 2
$57 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
"The bathroom in the room was quite dirty, the floor had stains, and the breakfast offered few options to choose from."
Reviewed on May 18, 2026

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
1500 Hickory Dr Las Cruces NM
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $71 total per night from Jun 1 to Jun 2
$71 total
Jun 1 - Jun 2
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
"Everything is fine."
Reviewed on May 19, 2026

Ramada Hotel & Conference Center by Wyndham Las Cruces
201 E University Avenue Las Cruces NM
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $93 total per night from Jun 1 to Jun 2
$93 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference center and conference ...
"The outsid & lobby area are very pretty. Theres a manlift about 6×4 feet instead of elevator & its vety slow * crowded. Staff are efficent & helpful. The air in room sounds like its going to jump out of ceiling. There a shortage of electrical outlets in room. They have power strips run instead of ..."
Reviewed on May 18, 2026

Comfort Suites University Las Cruces
2101 S Triviz Drive Las Cruces NM
Fully refundable
$88 nightly
The price is $103 total per night from Jun 14 to Jun 15
$103 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"The furniture needs an upgrade because there was a torn in the couch. It is also out dated.."
Reviewed on May 18, 2026

La Quinta Inn by Wyndham Las Cruces Mesilla Valley
790 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $50 total per night from May 24 to May 25
$50 total
May 24 - May 25
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference space and free ...
"didnt make the trip due to illness"
Reviewed on May 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent Dona Ana hotel reviews by fellow wanderers

La Quinta Inn by Wyndham Las Cruces Mesilla Valley
1 out of 5
Posted 6 hours ago
Travelocity Verified Review
"didnt make the trip due to illness"
A verified traveler stayed at La Quinta Inn by Wyndham Las Cruces Mesilla Valley
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