Book Hotels in Dona Ana, NM
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Top Dona Ana hotels

Drury Inn & Suites Las Cruces
1631 Hickory Loop Las Cruces NM
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Jul 8 to Jul 9
$128 total
Jul 8 - Jul 9
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Love Drury Inn! Great stay as always."
Reviewed on Jul 3, 2026

Comfort Suites Las Cruces I-25 North
236 N Telshor Blvd. Las Cruces NM
Fully refundable
$105 nightly
The price is $122 total per night from Aug 2 to Aug 3
$122 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot ...
"clean rooms staff were very nice"
Reviewed on Jun 29, 2026

Hotel Encanto de Las Cruces
705 S Telshor Blvd Las Cruces NM
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $147 total per night from Jul 5 to Jul 6
$147 total
Jul 5 - Jul 6
Total with taxes and fees
A nightclub, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling for business? Take advantage of the 24-hour business center, ...
"Nice place. Nice people. Got plenty of Rest!!"
Reviewed on Jul 3, 2026

Best Western Mission Inn
1765 S Main St Las Cruces NM
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $94 total per night from Jul 6 to Jul 7
$94 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...
"The staff were extremely pleasant and helpful. My room was clean and cool with air conditioning on when I checked in."
Reviewed on Jul 3, 2026

Days Inn by Wyndham Las Cruces
755 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $57 total per night from Jul 6 to Jul 7
$57 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
"The room was clean, pretty basic, and the pet fee is very reasonable."
Reviewed on Jul 3, 2026

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
1500 Hickory Dr Las Cruces NM
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $70 total per night from Jul 19 to Jul 20
$70 total
Jul 19 - Jul 20
Total with taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...
"Rooms were clean, staff was helpful, breakfast was yummy!!"
Reviewed on Jul 3, 2026

Ramada Hotel & Conference Center by Wyndham Las Cruces
201 E University Avenue Las Cruces NM
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $92 total per night from Jul 6 to Jul 7
$92 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference center and conference ...
"Very good staff, room as well"
Reviewed on Jul 2, 2026

Comfort Suites University Las Cruces
2101 S Triviz Drive Las Cruces NM
Fully refundable
$90 nightly
The price is $104 total per night from Aug 2 to Aug 3
$104 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Immaculate property, lobby and room, very quiet despite being right off the freeway. The young man at the front desk on the overnight shift was super friendly and helpful, even giving me some salt packets and advice on an over-the-counter medicine for my aching tooth! The other staff we encountered ..."
Reviewed on Jun 28, 2026

La Quinta Inn by Wyndham Las Cruces Mesilla Valley
790 Avenida De Mesilla Las Cruces NM
Fully refundableReserve now, pay when you stay
$53 nightly
The price is $62 total per night from Jul 6 to Jul 7
$62 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Traveling on business? Take advantage of the conference space and free ...
"Do not stay here! We’d stayed here in the past no issues not sure what changed but it was horrible. Doors kicked in, no key card control, staff was absent and not helpful, manager not helpful, smelled, lot's of suspicious activity going on- probably a popular stop for the police. When staff finally ..."
Reviewed on Jul 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent Dona Ana hotel reviews by fellow wanderers

Hotel Encanto de Las Cruces
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Nice place. Nice people. Got plenty of Rest!!"
A verified traveler stayed at Hotel Encanto de Las Cruces
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