
$442 Cheap American Airlines flights from Santa Fe to Roanoke (SAF to ROA)
Find The Best Day To Fly from Santa Fe to Roanoke
Amazing American Airlines SAF to ROA Flight Deals
The cheapest flights to Roanoke Regional found within the past 7 days were $603 round trip and $442 one way. Prices and availability subject to change. Additional terms may apply.
Discover our best American Airlines flight from Santa Fe SAF to Roanoke ROA
To find the best deals on flights to Santa Fe from Roanoke with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Santa Fe SAF to Roanoke ROA with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $603 to $713, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Santa Fe SAF to Roanoke ROA
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Santa Fe to Roanoke costs from $442. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Roanoke ROA from Santa Fe SAF with American Airlines
To find a cheap American Airlines flight from Santa Fe SAF to Roanoke ROA, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Santa Fe SAF to Roanoke ROA
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as May, or if you book a flight with a stopover.
Find nonstop flights from Santa Fe SAF to Roanoke ROA with American Airlines
If you’re keen to be on Roanoke soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Santa Fe SAF to Roanoke ROA
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Roanoke ROA from Santa Fe SAF with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Travelers ❤️ these 🏨 after their flight to Roanoke

Reviewed on May 4, 2025

Reviewed on May 4, 2025

Reviewed on May 5, 2025
Popular American Airlines Flight Routes from SAF
Top American Airlines Flight Routes from ROA
Domestic
- Los Angeles to Tokyo (LAX - HND)
- New York to Orlando (JFK - MCO)
- Newark Liberty Intl. Airport to Santiago (EWR - STI)
- New York to Santiago (JFK - STI)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- Philadelphia to Orlando (PHL - MCO)
- New York to San Juan (JFK - SJU)
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
- Seattle to Tokyo (SEA - HND)
- New York to Orlando (LGA - MCO)
International
- New York to Santiago (JFK - STI)
- New York to Montego Bay (JFK - MBJ)
- Los Angeles to Tokyo (LAX - HND)
- New York to Santo Domingo (JFK - SDQ)
- Seattle to Tokyo (SEA - NRT)
- Los Angeles to Tokyo (LAX - HND)
- New York to San Juan (JFK - SJU)
- Philadelphia to Orlando (PHL - MCO)
- New York to Santiago (JFK - STI)
- New York to Montego Bay (JFK - MBJ)