
$122 Cheap American Airlines flights from Myrtle Beach to Louisville (MYR to SDF)
Find The Best Day To Fly from Myrtle Beach to Louisville
Amazing American Airlines MYR to SDF Flight Deals
The cheapest flights to Louisville Intl. found within the past 7 days were $182 round trip and $122 one way. Prices and availability subject to change. Additional terms may apply.
SDF From MYR Economy Coach Packages on Similar Airlines



Frequently asked questions
Discover our best American Airlines flight from Myrtle Beach MYR to Louisville SDF
To find the best deals on flights to Myrtle Beach from Louisville with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Myrtle Beach MYR to Louisville SDF with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $182 to $259, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Myrtle Beach MYR to Louisville SDF
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Myrtle Beach to Louisville costs from $122. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Louisville SDF from Myrtle Beach MYR with American Airlines
To find a cheap American Airlines flight from Myrtle Beach MYR to Louisville SDF, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Myrtle Beach MYR to Louisville SDF
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as October, or if you book a flight with a stopover.
Find nonstop flights from Myrtle Beach MYR to Louisville SDF with American Airlines
If you’re keen to be on Louisville soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Myrtle Beach MYR to Louisville SDF
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Louisville SDF from Myrtle Beach MYR with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
Airport code | Country | Airport name | Number of flights |
---|---|---|---|
DFW | USA | Dallas-Fort Worth Intl. | 599 |
CLT | USA | Charlotte-Douglas Intl. | 536 |
ORD | USA | O'Hare Intl. | 317 |
PHL | USA | Philadelphia Intl. | 247 |
MIA | USA | Miami Intl. | 193 |
DCA | USA | Ronald Reagan Washington National | 152 |
PHX | USA | Sky Harbor Intl. | 141 |
LAX | USA | Los Angeles Intl. | 81 |
LGA | USA | LaGuardia | 72 |
BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Louisville

Crowne Plaza Louisville Airport Expo Ctr by IHG
Reviewed on Sep 15, 2025

Studio 6 Suites Louisville, KY – Airport/Expo Center
Reviewed on Sep 15, 2025

Fairfield Inn & Suites by Marriott Louisville Airport
Reviewed on Sep 12, 2025
Popular American Airlines Flight Routes from MYR
Top American Airlines Flight Routes from SDF
- American Airlines SDF to MCO
- American Airlines SDF to LGA
- American Airlines SDF to MSY
- American Airlines SDF to MIA
- American Airlines SDF to SJU
- American Airlines SDF to BOS
- American Airlines SDF to BWI
- American Airlines SDF to JFK
- American Airlines SDF to BHM
- American Airlines SDF to TPA
- American Airlines SDF to PNS
Top Flights for American Airlines originating from MYR
Domestic
- Newark Liberty Intl. Airport to Santiago (EWR - STI)
- Chicago to Mexico City (ORD - MEX)
- Minneapolis to Las Vegas (MSP - LAS)
- Philadelphia to Orlando (PHL - MCO)
- Lisbon to Toronto (LIS - YYZ)
- Los Angeles to New York (LAX - JFK)
- New York to Orlando (LGA - MCO)
- San Juan to Orlando (SJU - MCO)
- New York to Las Vegas (JFK - LAS)
- Dallas to Las Vegas (DFW - LAS)
International
- Boston to Orlando (BOS - MCO)
- Chicago to Orlando (ORD - MCO)
- Chicago to Mexico City (ORD - MEX)
- New York to Orlando (LGA - MCO)
- New York to Las Vegas (JFK - LAS)
- New York to Orlando (JFK - MCO)
- Dallas to Las Vegas (DFW - LAS)
- Philadelphia to Orlando (PHL - MCO)
- Lisbon to Toronto (LIS - YYZ)
- New York to Santiago (JFK - STI)