
$184 Cheap American Airlines flights from Detroit to Knoxville (DTW to TYS)
Find The Best Day To Fly from Detroit to Knoxville
Amazing American Airlines DTW to TYS Flight Deals
The cheapest flights to McGhee Tyson found within the past 7 days were $307 round trip and $184 one way. Prices and availability subject to change. Additional terms may apply.
TYS From DTW Economy Coach Packages on Similar Airlines



Discover our best American Airlines flight from Detroit DTW to Knoxville TYS
To find the best deals on flights to Detroit from Knoxville with American Airlines, just enter your travel dates, filter by American Airlines, and hit search. You’ll find flights to choose from and can sort by price, flight duration, and arrival or departure time.
Return flights from Detroit DTW to Knoxville TYS with American Airlines
If you’re planning a round trip, booking return flights with American Airlines is usually the most cost-effective option. With airfares ranging from $307 to $340, it’s easy to find a flight that suits your budget. Prices and availability subject to change. Additional terms may apply.
Book one-way American Airlines flights from Detroit DTW to Knoxville TYS
A one-way ticket gives you much greater flexibility—allowing you to choose your return date, destination, and time whenever you’re ready. By booking in advance you can find great deals on one-way tickets too. Right now, a one-way American Airlines flight from Detroit to Knoxville costs from $184. Prices and availability subject to change. Additional terms may apply.
The easy way to find cheap flights to Knoxville TYS from Detroit DTW with American Airlines
To find a cheap American Airlines flight from Detroit DTW to Knoxville TYS, sort your search results by price or filter by budget. Thanks to Travelocity’s Price Match Promise, if you find a better airfare deal anywhere else within 24 hours, we’ll credit or refund the difference.
How to find our best airfare deals on American Airlines flights from Detroit DTW to Knoxville TYS
If you’re looking for cheap flights, it helps to be flexible when it comes to your travel dates. You’ll usually find lower cost tickets when you travel during quieter months such as October, or if you book a flight with a stopover.
Find nonstop flights from Detroit DTW to Knoxville TYS with American Airlines
If you’re keen to be on Knoxville soil fast, don’t waste time with a stopover—filter your search results to show direct American Airlines flights only. The journey takes around hour(s) min(s) – so you’ll be there before you know it.
Flexible airline tickets for American Airlines flights from Detroit DTW to Knoxville TYS
Make sure you’re not out of pocket if plans change by choosing a flexible ticket with penalty-free amendment and cancellation options. Use our ‘no change fee’ filter to see which flights have this option.
There are a lot of reasons to book your flights to Knoxville TYS from Detroit DTW with American Airlines on Travelocity
At Travelocity our vast and up-to-the-minute inventory puts all of our best flight deals in one place. So, whether you’re traveling on business or jetting off with friends and family, you can trust Travelocity to get you there.
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Popular American Airlines Flight Routes from DTW
- American Airlines DTW to MCO
- American Airlines DTW to SJU
- American Airlines DTW to MSP
- American Airlines DTW to RSW
- American Airlines DTW to SEA
- American Airlines DTW to TPA
- American Airlines DTW to BNA
- American Airlines DTW to IAH
- American Airlines DTW to PHX
- American Airlines DTW to PNS
- American Airlines DTW to CUN
Top American Airlines Flight Routes from TYS
Top Flights for American Airlines originating from DTW
Domestic
- Boston to Orlando (BOS - MCO)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- Los Angeles to Honolulu (LAX - HNL)
- Dallas to Las Vegas (DFW - LAS)
- New York to Orlando (JFK - MCO)
- Newark Liberty Intl. Airport to Las Vegas (EWR - LAS)
- New York to Santiago (JFK - STI)
- Orlando to San Juan (MCO - SJU)
- New York to Las Vegas (JFK - LAS)
- Boston to Orlando (BOS - MCO)
International
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
- Los Angeles to San Salvador (LAX - SAL)
- New York to Montego Bay (JFK - MBJ)
- Newark Liberty Intl. Airport to San Juan (EWR - SJU)
- Atlanta to Las Vegas (ATL - LAS)
- Orlando to San Juan (MCO - SJU)
- Los Angeles to San Salvador (LAX - SAL)
- Newark Liberty Intl. Airport to Orlando (EWR - MCO)
- New York to Montego Bay (JFK - MBJ)
- New York to Santiago (JFK - STI)
Most Popular
- DFW to BNA Flights
- MSP to BNA Flights
- ATL to BNA Flights
- LAX to BNA Flights
- BNA to JFK Flights
- DTW to BNA Flights
- JetBlue Airways Boston (BOS) to Nashville (BNA) flights
- PHL to BNA Flights
- BNA to ATL Flights
- BNA to DFW Flights
- TPA to BNA Flights
- Delta Memphis (MEM) to Las Vegas (LAS) flights
- BNA to LAX Flights
- BNA to TPA Flights
- RDU to BNA Flights
- MEM to ATL Flights
- JetBlue Airways New York (JFK) to Nashville (BNA) flights
- JFK to BNA Flights
- BNA to MCO Flights
- ORD to BNA Flights
- BNA to DEN Flights
- MEM to MCO Flights
- CLT to BNA Flights
- BNA to MIA Flights
- MEM to DFW Flights
- American Airlines Nashville (BNA) to Las Vegas (LAS) flights
- BNA to ORD Flights
- PHX to BNA Flights
- MCO to BNA Flights
- GRR to MCO Flights