$239 Cheap American Airlines flights from Des Moines to Knoxville (DSM to TYS)

Find The Best Day To Fly from Des Moines to Knoxville

Amazing American Airlines DSM to TYS Flight Deals

The cheapest flights to McGhee Tyson found within the past 7 days were $249 round trip and $239 one way. Prices and availability subject to change. Additional terms may apply.

Sat, Sep 20 - Thu, Sep 25
DSM
Des Moines
TYS
Knoxville
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Sep 20 from Des Moines to Knoxville, returning Thu, Sep 25, priced at $249 found 1 day ago
Sat, Aug 30 - Wed, Sep 3
DSM
Des Moines
TYS
Knoxville
$259 Roundtrip, found 2 days ago
$259
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 30 from Des Moines to Knoxville, returning Wed, Sep 3, priced at $259 found 2 days ago
Sat, Aug 30 - Wed, Sep 3
DSM
Des Moines
TYS
Knoxville
$265 Roundtrip, found 2 days ago
$265
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 30 from Des Moines to Knoxville, returning Wed, Sep 3, priced at $265 found 2 days ago
Sat, Sep 20 - Thu, Sep 25
DSM
Des Moines
TYS
Knoxville
$296 Roundtrip, found 1 day ago
$296
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Sep 20 from Des Moines to Knoxville, returning Thu, Sep 25, priced at $296 found 1 day ago
Fri, Sep 5 - Sat, Sep 13
DSM
Des Moines
TYS
Knoxville
$298 Roundtrip, found 6 hours ago
$298
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Sep 5 from Des Moines to Knoxville, returning Sat, Sep 13, priced at $298 found 6 hours ago
Sat, Aug 30 - Wed, Sep 3
DSM
Des Moines
TYS
Knoxville
$301 Roundtrip, found 2 days ago
$301
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 30 from Des Moines to Knoxville, returning Wed, Sep 3, priced at $301 found 2 days ago

Frequently asked questions

Can I catch a flight from Des Moines Intl. Airport to TYS right now?
It's prudent to find out about any quarantine requirements and travel advice reports in effect in your destination. Make sure you go to our Covid-19 Travel Advisor for up-to-date information on booking a flight to Knoxville Airport from Des Moines Intl. Airport (DSM).
What terminal is American Airlines at Des Moines Intl. Airport?
You should find out which terminal American Airlines leaves from at Des Moines Intl. Airport when you receive your boarding pass. The same goes for information about your arrival at TYS. If those details are missing, get in touch with your airline.
Are there American Airlines non-stop flights from DSM to TYS?
As you can't fly direct from DSM to TYS with American Airlines, make the most of your layover. Relax with some drinks at a comfortable airport bar, or stroll about the terminal and enjoy some retail therapy.
How long is an American Airlines flight from DSM to TYS?
From the minute your American Airlines plane pushes back from the gate at DSM to the moment it pulls into McGhee Tyson Airport (TYS), your trip will take about 3 hours and 45 minutes. With such a quick flight time, it's an ideal spur-of-the-moment getaway.
How many direct and indirect flights does American Airlines fly from DSM to TYS?
If you're considering a trip from DSM to TYS, you can choose from 2 American Airlines flights every day.
If I am not able to travel due to COVID-19, can I change my booking to a later date?
For more info about changing your flight to Knoxville Airport, please visit our Customer Service Portal.
What is the best day to buy a plane ticket?
This just in! Airfares offered on Thursdays tend to be the cheapest, according to flight demand on Travelocity in 2021. Tuesday and Wednesday prices are also good, but you may want to prepare your budget if booking during the weekend, as data shows that is when prices are generally at their highest.
What are the cheapest days to fly?
Frequent travelers may already know this, but earlier in the week can be the cheapest time to fly. In 2021, flights departing on a Monday were generally the cheapest of the week, whereas you may pay a premium for weekend flights when demand is usually high. On average, tickets were most expensive for Saturday departures, so if you need to fly out on a weekend, you might look for deals ahead of time.
How far in advance can you book a flight?
Trying to figure out how early you should book your flight? It's possible to start comparing international airfares on Travelocity up to 12 months in advance. However, it does depend on the carrier as not all airlines release their prices that far out. According to our 2021 flight demand trends, last minute planners can still bag a bargain with some of the cheapest fares appearing 0-2 weeks prior to their travel dates.*According to flight demand on Travelocity.com from January to December 2021. Savings are subject to change based on departure location, date and destination.
American Airlines Airports
Hop on a(n) American Airlines flight today by flying to many destinations out of these domestic and international airports:
Airport code
Country
Airport name
Number of flights
DFWUSADallas-Fort Worth Intl.599
CLTUSACharlotte-Douglas Intl.536
ORDUSAO'Hare Intl.317
PHLUSAPhiladelphia Intl.247
MIAUSAMiami Intl.193
DCAUSARonald Reagan Washington National152
PHXUSASky Harbor Intl.141
LAXUSALos Angeles Intl.81
LGAUSALaGuardia72
BOSUSALogan Intl.57

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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