Southeast Missouri , MO Pet Friendly Hotels

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Top Southeast Missouri Pet Friendly Hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $117 total per night from Jul 20 to Jul 21
$117 total
Jul 20 - Jul 21
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.4/10 Exceptional! (1,006 reviews)
"The staff here from check in to the morning breakfast were welcoming and friendly. Cost was reasonable. I loved seeing the dogs and that it is pet friendly. Everything was clean. The location was close to places to eat - we even walked to El Bracero for dinner. I would highly recommend"

Reviewed on Jul 11, 2025

Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $109 total per night from Jul 19 to Jul 20
$109 total
Jul 19 - Jul 20
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (1,004 reviews)
"Excellent place to stay. Good breakfast choices. Good pool and hot tub."

Reviewed on Jul 9, 2025

Pear Tree Inn Sikeston
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

2220 N Westwood Blvd, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Jul 20 to Jul 21
$106 total
Jul 20 - Jul 21
Total includes taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
9.2/10 Wonderful! (883 reviews)
"All the staff was absolutely WONDERFUL!!!!"

Reviewed on Jul 7, 2025

Drury Inn & Suites Poplar Bluff
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $76 total per night from Jul 20 to Jul 21
$76 total
Jul 20 - Jul 21
Total includes taxes and fees
Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.
8.8/10 Excellent! (1,010 reviews)
Nice One-Night Stay
"Stopped in in late June. One night stay. Rooms was fine. Bed was comfy and pillows were good. The 'continental' breakfast was severely lacking."

Reviewed on Jul 6, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve

21958 Hwy 32, Ste Genevieve, MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $104 total per night from Jul 27 to Jul 28
$104 total
Jul 27 - Jul 28
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
8.6/10 Excellent! (579 reviews)
Gross cleaning service in front of guests at bkfst
"The first morning we ate breakfast (24th) as we were in the breakfast room I witnessed a female cleaning the area. She used a rag to scrub at the floor in front of the coffee machine. Nothing unusual, but I kept watching. She then stood up, rinsed out the rag then immediately started to wipe down ..."

Reviewed on Jun 27, 2025

Microtel Inn & Suites by Wyndham Sainte Genevieve
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $83 total per night from Jul 16 to Jul 17
$83 total
Jul 16 - Jul 17
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
7.8/10 Good! (1,013 reviews)
"It was very clean and the price was great. But saying that, it was"

Reviewed on Jul 14, 2025

Motel 6 Poplar Bluff, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd, Festus, MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $125 total per night from Jul 17 to Jul 18
$125 total
Jul 17 - Jul 18
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
7.8/10 Good! (815 reviews)
"Clean and friendly service"

Reviewed on Jul 9, 2025

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $92 total per night from Jul 17 to Jul 18
$92 total
Jul 17 - Jul 18
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...
7.2/10 Good! (1,000 reviews)
Keep up the renovations
"This hotel looked like an old apartment building renovation into a hotel with much wrk in progress. Decent stay. Spacious. Very minimal breakfast offerings. The geese outside sure left messes everywhere but the greeting cat was a nice touch"

Reviewed on Jun 28, 2025

Days Inn and Suites by Wyndham Sikeston
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

It’s hard to leave for a trip when the last image you have is of your four-legged best friend staring out the living-room window with those sad eyes as you drive away. You don’t have to leave Spot behind any longer, he can finally join you on your adventures.

Turn your trip into a family getaway by booking a stay at one of the pet-friendly hotels in Southeast Missouri for you and your furry kids. No more sending them to pet hotels or leaving them home alone to run amok in the house. Southeast Missouri pet-friendly hotels are perfect for weekend escapes with your pooch, kitty, bird, or fish. These accommodations not only welcome your pets, but they offer many services to help make your stay more relaxing. Things like on-site grooming and complimentary dog walking are some of the amenities provided. In most cases, you’ll also be near outdoor spaces like dog parks if you both need some exercise, as well as pet-friendly restaurants.

Don’t ever feel guilty about leaving your beloved Maximus behind on a trip again. Travelocity wants to help the both of you enjoy a wonderful vacation together. Search our extensive inventory of the best pet-friendly hotels in Southeast Missouri and book your stay now.

Southeast Missouri hotels essential information

Accommodation
582 hotels
Lowest Price
$76
Highest Price
$125
Popular hotels
Motel 6 Poplar Bluff, MO, Microtel Inn & Suites by Wyndham Sainte Genevieve, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, Drury Inn & Suites Sikeston, MO, Pear Tree Inn Sikeston, Drury Inn & Suites Poplar Bluff, Days Inn and Suites by Wyndham Sikeston, Pear Tree Inn Cape Girardeau Near the Medical Center

Recent Southeast Missouri hotel reviews by fellow wanderers

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