Explore 12 Luxury Hotels in Southeast Missouri

Name: Baymont by Wyndham Festus
Price range: $93 total
Rating: 6.8

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in Southeast Missouri

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

This apartment features a water park, laundry facilities, and barbecue grills.

9.8/10 Exceptional! (170 reviews)

Great place! It was exactly as advertised. We were so close to shops and restaurants. We will definitely be back!

Reviewed on Oct 12, 2025

Get rates

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$70 nightly

$79 total

Dec 15 - Dec 16

Total with taxes and fees

Free WiFi in public areas and express check-out are available at this hotel. Staff at the 24-hour front desk can provide around-the-clock assistance.

8.8/10 Excellent! (1,005 reviews)

Room could have been cleaner and no cups for coffee. Staff at front desk OUTSTANDING.

Reviewed on Dec 6, 2025

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$76 nightly

$80 total

Dec 11 - Dec 12

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...

7.8/10 Good! (1,000 reviews)

Love the updated rooms and the vending area.

Reviewed on Dec 6, 2025

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

Fully refundableReserve now, pay when you stay

$83 nightly

$94 total

Dec 14 - Dec 15

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...

7.8/10 Good! (908 reviews)

Vary clean

Reviewed on Nov 30, 2025

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Fully refundableReserve now, pay when you stay

$63 nightly

$72 total

Dec 14 - Dec 15

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,001 reviews)

Very nice room, staff was nice. The tv room and bathroom were cold. No heat in those rooms.

Reviewed on Dec 7, 2025

Baymont by Wyndham Festus

1200 W. Gannon Drive Festus MO

Fully refundableReserve now, pay when you stay

$81 nightly

$93 total

Dec 14 - Dec 15

Total with taxes and fees

This hotel features an indoor pool and a gym. Families will appreciate the arcade/game room and barbecue grills. Relax with a drink at the bar/lounge and enjoy ...

6.8/10 (918 reviews)

Room was clean and comfortable for an overnight stay

Reviewed on Nov 30, 2025

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$55 nightly

$62 total

Dec 18 - Dec 19

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...

6.4/10 (621 reviews)

Just had a good time and everyone working was super friendly

Reviewed on Nov 28, 2025

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

This motel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...

5.6/10 (831 reviews)

Awesome

Reviewed on Nov 11, 2025

Get rates

Don't see what you're looking for?

See all available properties in Southeast Missouri

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southeast Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southeast Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southeast Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southeast Missouri, and plan your next opulent escape.

Southeast Missouri hotels essential information

Accommodation	619 hotels
Lowest Price	$62
Highest Price	$94
Popular hotels	Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Baymont by Wyndham Festus