Stay & Play at the Best Casino Hotels in Southeast Missouri

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Top Southeast Missouri Casino Resorts & Hotels

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street, Cape Girardeau, MO
Free Cancellation
$99 nightly
The price is $112 total per night
$112 total
Jun 8 - Jun 9
Total includes taxes and fees
A full-service spa and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public ...
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
$172 nightly
The price is $183 total per night
$183 total
Jun 3 - Jun 4
Total includes taxes and fees
This aparthotel's 2 outdoor tennis courts and gym are among the featured amenities. There's fun for all ages with mini golf and a playground, and barbecue grills ...
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84, Hayti, MO
Free Cancellation
Reserve now, pay when you stay
$99 nightly
The price is $113 total per night
$113 total
Jun 2 - Jun 3
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $107 total per night
$107 total
Jun 1 - Jun 2
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$63 nightly
The price is $71 total per night
$71 total
Jun 1 - Jun 2
Total includes taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$58 nightly
The price is $66 total per night
$66 total
Jun 1 - Jun 2
Total includes taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free WiFi in public areas and express check-out. Staff at the 24-hour front desk can provide around-the-clock ...
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
Free Cancellation
$78 nightly
The price is $94 total per night
$94 total
Jun 15 - Jun 16
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, ...
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd, Jackson, MO
Free Cancellation
Reserve now, pay when you stay
$87 nightly
The price is $94 total per night
$94 total
May 29 - May 30
Total includes taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
Quality Inn

Quality Inn

2.5 out of 5
2011 North Kingshighway, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$64 nightly
The price is $72 total per night
$72 total
May 29 - May 30
Total includes taxes and fees
An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...
Quality Inn Hayti North

Quality Inn Hayti North

2.5 out of 5
1500 Highway 84, Hayti, MO
Free Cancellation
Reserve now, pay when you stay
$62 nightly
The price is $71 total per night
$71 total
Jun 15 - Jun 16
Total includes taxes and fees
A seasonal outdoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. ...
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

2.5 out of 5
505 North Kingshighway Street, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$62 nightly
The price is $70 total per night
$70 total
May 29 - May 30
Total includes taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Staff at the 24-hour front desk can provide around-the-clock ...
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Missouri Casino Hotels

You shouldn’t be betting blind when it comes to finding a great deal on accommodations near your next gaming destination. Play your cards right and book a reservation for your next trip with confidence. Whether you’re a high roller or casual player, Travelocity has a wide selection of Southeast Missouri hotels near a casino for you to peruse. You won’t need to spend your whole bankroll to get in on the action.

Brush up on your poker face while you take in the view from your hotel room, then head to the casino floor to test your luck. Take a break to load up your plate at the buffet or grab a coffee for a shot of energy to keep you on your toes at the tables. Hotels close to a casino in Southeast Missouri offer the convenience of easy access to your favorite games of chance, so you’ll feel like you’ve hit the jackpot.

Check out a great variety of Southeast Missouri hotels by a casino and discover the one that will make your dreams come true. Lady Luck is on your side when you trust your hotel reservation to Travelocity. Book with us today and know that this is one bet that always pays off big.

Southeast Missouri hotels essential information

Accommodation
572 hotels
Lowest Price
$66
Highest Price
$183
Popular hotels
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG, Drury Inn & Suites Hayti Caruthersville, Town House Inn Cape Giradreau, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, Pear Tree Inn Cape Girardeau Near the Medical Center, Candlewood Suites Cape Girardeau by IHG, Pear Tree Inn Cape Girardeau West, Drury Inn & Suites Cape Girardeau, Quality Inn, Quality Inn Hayti North, Comfort Suites Jackson-Cape Girardeau

Recent Southeast Missouri hotel reviews by fellow wanderers

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"I thought the property was very clean and appealing. Our check in clerk for our 1st night stay on May 22nd was very friendly, and helpful, however our 2nd stay on May 25th our clerk was unpleasant never said hello never smiled. She wasn't rude but she seemed very unfriendly and like she didn't want to be there. But our rooms were very clean, the breakfast was good, and the breakfast staff was very friendly as well. I would definitely stay here again in the future."
A verified traveler stayed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG