Explore 7 Luxury Hotels in Sikeston

Name: Quality Inn Cape Girardeau North
Price range: $75 total
Rating: 7.2

Best Luxury Hotels in Sikeston

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

This apartment featured laundry facilities and barbecue grills.

10/10 Exceptional! (224 reviews)

Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!

Reviewed on Dec 15, 2025

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Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$94 nightly

$108 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...

9.4/10 Exceptional! (1,003 reviews)

Pool not too cold and it was even snowing at one point. Staff was very friendly and helpful. Never had to wait for elevator. Breakfast waffles were excellent. Room was spacious. I’ve stayed in a lot of hotels, and this is one of the best. They get a 100/10 for amenities!

Reviewed on Mar 18, 2026

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$90 nightly

$102 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...

9.4/10 Exceptional! (1,002 reviews)

Always the friendliest staff, like they love their job and feel respected. Always a clean room. Had a suite for this day, and ver spacious, felt like an apartment.

Reviewed on Mar 17, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Fully refundableReserve now, pay when you stay

$68 nightly

$78 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,000 reviews)

The building is dated BUT clean and roomy!! This is our second stay here. Would stay here again.

Reviewed on Mar 15, 2026

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$67 nightly

$75 total

Mar 24 - Mar 25

Total with taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like English breakfast and WiFi in public ...

7.2/10 Good! (710 reviews)

I wouldn’t recommend this property. Our first room was given to someone else. Then the room they gave us hadn’t been cleaned the bedding was all over bathroom had dirty towels on the floor. The hall had garbage by some of the rooms. Plus there was a big hole in the ceiling in the hall by our room ...

Reviewed on Mar 13, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sikeston Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Sikeston luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Sikeston to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Sikeston will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Sikeston, and plan your next opulent escape.

Sikeston hotels essential information

Accommodation	287 hotels
Lowest Price	$75
Highest Price	$108
Popular hotels	Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Quality Inn Cape Girardeau North, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau

Popular Luxury Stays in Sikeston

Recent Sikeston Hotel Reviews By Fellow Wanderers

Drury Inn & Suites Sikeston, MO

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"Pool not too cold and it was even snowing at one point. Staff was very friendly and helpful. Never had to wait for elevator. Breakfast waffles were excellent. Room was spacious. I’ve stayed in a lot of hotels, and this is one of the best. They get a 100/10 for amenities! "

A verified traveler stayed at Drury Inn & Suites Sikeston, MO