Book Hotels in Puxico, MO
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Top Puxico hotels

Lake Wappapello
8005 Missouri 172 Williamsville MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $90 total per night from Apr 6 to Apr 7
$90 total
Apr 6 - Apr 7
Total with taxes and fees
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went.
Reviewed on Sep 28, 2025

Hampton Inn By Hilton Dexter
2179 Gill Plaza Drive Dexter MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $110 total per night from Apr 12 to Apr 13
$110 total
Apr 12 - Apr 13
Total with taxes and fees
Stay at this hotel in Dexter. Popular attractions The Heritage House and Keller Veteran Memorial are located nearby.
Great place, nice and clean
Reviewed on Mar 27, 2026

Fairfield Inn & Suites by Marriott Poplar Bluff
3109 Oak Grove Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $124 total per night from Apr 7 to Apr 8
$124 total
Apr 7 - Apr 8
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
Breakfast was really good and fresh. Room was clen
Reviewed on Apr 4, 2026

Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $105 total per night from Apr 12 to Apr 13
$105 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business ...
Clean comfortable hotel. Nice gym, breakfast ok.
Reviewed on Apr 2, 2026

Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Apr 12 to Apr 13
$106 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
The staff were so accomodating and caring when my son slipped and fell. The guy at the front desk provided all the first aid supplies we needed. I plan on staying there again of we pass through.
Reviewed on Mar 28, 2026

Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd Poplar Bluff MO
Fully refundable
$101 nightly
The price is $114 total per night from Apr 12 to Apr 13
$114 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
Great experience, our only disappointment was that we were not able enjoy our free breakfast as it was not available early in the A.M.
Reviewed on Apr 3, 2026

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $69 total per night from Apr 6 to Apr 7
$69 total
Apr 6 - Apr 7
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...
Very basic. No shampoo or facial tissue. Seemed unusual, but it was clean and in good condition.
Reviewed on Mar 29, 2026

Travelodge by Wyndham Dexter
1608 E Business US 60 Dexter MO
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $115 total per night from Apr 12 to Apr 13
$115 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the business center. A restaurant, ...
Clean room, staff was super helpful
Reviewed on Mar 21, 2026

Super 8 by Wyndham Poplar Bluff Missouri
2831 N Westwood Blvd Poplar Bluff MO
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $63 total per night from May 4 to May 5
$63 total
May 4 - May 5
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Truck parking
Reviewed on Mar 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Puxico hotel reviews by fellow wanderers

Fairfield Inn & Suites by Marriott Poplar Bluff
5 out of 5
Posted 5 hours ago
Travelocity Verified Review
"Breakfast was really good and fresh. Room was clen"
A verified traveler stayed at Fairfield Inn & Suites by Marriott Poplar Bluff
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