Deals on vacations and trips to Otay Mesa

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Otay Mesa flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel

2.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
Aug 23 - Aug 26
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
This aparthotel features free WiFi in public areas, laundry facilities, and self parking. Staff at the 24-hour front desk can provide around-the-clock assistance.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
per person
Jul 11 - Jul 15
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. There's a gym on site, and a 24-hour front desk and a coffee shop are also provided.
Roam and Board

Roam and Board

2 out of 5
Save 100% on your flight
per person
Aug 22 - Aug 28
found 4 hours ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
This campground's 2 outdoor tennis courts and outdoor pool are among the featured amenities. Guests will appreciate free perks like free self parking and WiFi in public areas. Laundry facilities and barbecue grills are also provided.
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
Jul 5 - Jul 12
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas and valet parking. Enjoy the a rooftop terrace and unwind at the bar/lounge and poolside bar.
The New Inn

The New Inn

4 out of 5
Save 100% on your flight
per person
Jul 31 - Aug 4
found 1 day ago
Roundtrip flight included
San Francisco (SFO) to San Diego (SAN)

Top Otay Mesa hotels deals

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
$256 nightly
The price is $297 total per night
$297 total
Jun 12 - Jun 13
Total includes taxes and fees
This eco-certified hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the hot tub and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$114 nightly
The price is $130 total per night
$130 total
Jun 16 - Jun 17
Total includes taxes and fees
This Art Deco hotel includes 2 restaurants, an outdoor pool, and a hot tub. Enjoy the gym and perks like free WiFi. A bar/lounge, a 24-hour front desk, and a coffee shop are also provided.
Pool
Hot Tub
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$209 nightly
The price is $240 total per night
$240 total
Jun 1 - Jun 2
Total includes taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and visit the 2 poolside bars and bar/lounge for drinks.
Pool
Hot Tub
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$230 nightly
The price is $262 total per night
$262 total
Jun 5 - Jun 6
Total includes taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 5 restaurants. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the 2 outdoor pools and perks like free WiFi.
Pool
Hot Tub
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
$278 nightly
The price is $320 total per night
$320 total
Jun 4 - Jun 5
Total includes taxes and fees
A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this eco-certified hotel. There's fun for all ages with a children's pool and an arcade/game room, and families will appreciate the picnic area. Enjoy the outdoor pool and perks like free WiFi.
Pool
Hot Tub
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$116 nightly
The price is $133 total per night
$133 total
Jun 1 - Jun 2
Total includes taxes and fees
This hotel features an outdoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Pool
Hot Tub
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Beaches and islands, amusement parks and water sports, bonfires, and sunsets: this outdoor playground buzzes both on land and in the water.

Mission Bay

Frequently asked questions

How much are vacation packages to Otay Mesa?
Splash out on a fulfilling travel experience in Otay Mesa with a vacation package starting at $275. Reserving your tours, flights and hotels with Travelocity is simple. What’s more, our deals will leave you with more savings for fun.
Where can I get the best vacation package deals for Otay Mesa?
Snapping up a great package deal to Otay Mesa is a breeze with Travelocity. With 400 airlines and 1,000,000 properties all over the globe, you won’t be short of choice when it comes to picking your hotels and flights.
Why should I purchase my Otay Mesa vacation package via Travelocity?
From enchanting destinations to one-of-a-kind experiences, we have everything you need to satisfy your wanderlust. Our 24/7 customer care will also ensure you’re taken care of during your vacation. And don’t fret if you notice a cheaper price on your reservation, we’ll match it. That’s our Price Match Guarantee.
Can I save on my Otay Mesa car rental if I bundle it with a hotel or flight?
Sure can — and if you also add a tour to your Otay Mesa vacation package, you’ll save some more. With one of our affordable packages, you can find things to do in the region that are right up your alley. Then, jump in your rental car and work your way through the list. Disneyland® Resort is one awesome attraction to key into your GPS. It’s 100 mi from Otay Mesa.

Photos of local treasures

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