Deals on vacations and trips to Otay Mesa

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Otay Mesa flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.
Quiet Mind Mountain Lodge, Retreat and Spa

Quiet Mind Mountain Lodge, Retreat and Spa

4.5 out of 5
Save 100% on your flight
per person
Aug 29 - Sep 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
A full-service spa and a hot tub are featured at this smoke-free lodge. Enjoy the gym and perks like free self parking and free WiFi. There's a sauna on site, and a terrace and a garden are also provided.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
Sep 5 - Sep 10
found 2 days ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
A restaurant and a 24-hour gym are featured at this hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Self parking, a coffee shop, and a lobby fireplace are also offered.
Barsala City Villas

Barsala City Villas

2.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
Sep 27 - Oct 3
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
This aparthotel features free WiFi in public areas, laundry facilities, and a virtual front desk.
Sand Castle Inn

Sand Castle Inn

2.5 out of 5
Save 100% on your flight
per person
Sep 27 - Oct 3
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. A picnic area, express check-in, and express check-out are also on offer.
The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar

3 out of 5
Downtown San Diego
Save 100% on your flight
per person
Sep 5 - Sep 10
found 2 days ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
A restaurant and a bar/lounge are featured at this hotel. Self parking and luggage storage are also offered on site.

Top Otay Mesa hotels deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
Free Cancellation
$139 nightly
The price is $158 total per night
$158 total
Aug 10 - Aug 11
Total includes taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
Pool
Breakfast included
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$119 nightly
The price is $137 total per night
$137 total
Jul 22 - Jul 23
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a hot tub. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and visit the 2 bars/lounges and poolside bar for drinks.
Pool
Hot Tub
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$169 nightly
The price is $195 total per night
$195 total
Jul 27 - Jul 28
Total includes taxes and fees
This smoke-free hotel includes 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, express check-out, and free airport shuttle. There's a bar/lounge on site, and concierge services and free newspapers are also provided.
Pool
Free airport shuttle
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
$222 nightly
The price is $257 total per night
$257 total
Jul 22 - Jul 23
Total includes taxes and fees
This eco-certified hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the hot tub and visit the 3 bars/lounges and poolside bar for drinks.
Pool
Hot Tub
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
$170 nightly
The price is $196 total per night
$196 total
Aug 18 - Aug 19
Total includes taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and visit the 2 poolside bars and bar/lounge for drinks.
Pool
Hot Tub
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
$259 nightly
The price is $300 total per night
$300 total
Aug 17 - Aug 18
Total includes taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 5 restaurants. Families will appreciate the children's pool and onsite laundry facilities. Enjoy the 2 outdoor pools and perks like free WiFi.
Pool
Hot Tub
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
Mission Bay featuring a sandy beach

Mission Bay

4.5/5(2,386 reviews)

Beaches and islands, amusement parks and water sports, bonfires, and sunsets: this outdoor playground buzzes both on land and in the water.

Mission Bay
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and entertainment choices.

San Diego Convention Center

Frequently asked questions

How much are vacation packages to Otay Mesa?
Splash out on a fulfilling travel experience in Otay Mesa with a vacation package starting at $339. Reserving your tours, flights and hotels with Travelocity is simple. What's more, our deals will leave you with more savings for fun.
Where can I get the best vacation package deals for Otay Mesa?
Snapping up a great package deal to Otay Mesa is a breeze with Travelocity. With 400 airlines and 1,000,000 properties all over the globe, you won't be short of choice when it comes to picking your hotels and flights.
Why should I purchase my Otay Mesa vacation package via Travelocity?
From enchanting destinations to one-of-a-kind experiences, we have everything you need to satisfy your wanderlust. Our 24/7 customer care will also ensure you're taken care of during your vacation. And don't fret if you notice a cheaper price on your reservation, we'll match it. That's our Price Match Guarantee.
Can I save on my Otay Mesa car rental if I bundle it with a hotel or flight?
Sure can — and if you also add a tour to your Otay Mesa vacation package, you'll save some more. With one of our affordable packages, you can find things to do in the region that are right up your alley. Then, jump in your rental car and work your way through the list. Disneyland® Resort is one awesome attraction to key into your GPS. It's 100 mi from Otay Mesa.

Photos of local treasures

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