Book Hotels in Cairo, MO
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Top Cairo hotels

Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness
Cairo MO
This vacation home featured laundry facilities and barbecue grills.
Host went above and beyond to make our anniversary stay special. Cabin is always welcoming and homey.
Reviewed on Dec 8, 2025

'grace Place' Clark House on Farm: Shared Hot Tub!
Clark MO
An outdoor pool is featured at this cottage, along with free WiFi in public areas.
Grace Place
Very clean with a wonderful country atmosphere. Perfect size for 1-2 people to share. The farm animals won my heart over!!!!!!!
Reviewed on Aug 18, 2025

Unwind on Vine
Macon MO
$160 nightly
The price is $160 total per night from Dec 20 to Dec 21
$160 total
Dec 20 - Dec 21
Total with taxes and fees
This vacation home features laundry facilities.
House was very easy to locate. It was in the middle of town and close to many places to eat. House has a very good view of the sunrise. Since it snowed during our stay, we very much appreciated the use of the garage. House was decorated for the holiday which was very thoughtful and nice.
Reviewed on Dec 14, 2025

Comfort Inn & Suites Moberly
1801 W Outer Rd Moberly MO
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $103 total per night from Jan 18 to Jan 19
$103 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
A gym, free self parking, and free newspapers are featured at this hotel. Guests will appreciate free perks like buffet breakfast and WiFi in public areas. A ...
Great staff!
Reviewed on Dec 8, 2025

Super 8 by Wyndham Moberly MO
300 E Highway 24 Moberly MO
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $72 total per night from Jan 4 to Jan 5
$72 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. Guests will appreciate free perks like on-the-go breakfast and WiFi in ...
Clean!
Reviewed on Dec 5, 2025

Simple Rewards Inn Shelbina
711 North Highway 15 Shelbina MO
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $101 total per night from Dec 19 to Dec 20
$101 total
Dec 19 - Dec 20
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
Was a lot nicer than I was expecting
Reviewed on Nov 29, 2025

Super 8 by Wyndham Macon
203 E Briggs Dr Macon MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $79 total per night from Jan 1 to Jan 2
$79 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This motel features free WiFi in public areas, barbecue grills, and free self parking. Enjoy the free on-the-go breakfast each morning. Staff at the 24-hour ...
I had a handicap accessible room. The room was clean and set up well for my issues getting around. Staff were very polite. Bed was actually comfortable.
Reviewed on Dec 8, 2025

OYO Travelier Motel
201 E Briggs Dr Macon MO
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $76 total per night from Jan 1 to Jan 2
$76 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and free parking. Guests will appreciate freebies like continental breakfast and free self ...
bathroom was not heated so that was a bit uncomfortable. but to be honest the clerk had to change rooms for us because the heat wasn't working which was the reason for the temp in room. he was very helpful in taking care of the problem.
Reviewed on Dec 8, 2025

Americas Best Value Inn & Suites Macon at Sunset Dr
28933 Sunset Drive Macon MO
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $69 total per night from Jan 10 to Jan 11
$69 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
A restaurant and a bar/lounge are featured at this motel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
Was clean had comfortable bed. Older motel but in decent shape. Would stay there again
Reviewed on Nov 17, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent Cairo hotel reviews by fellow wanderers

Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness
5 out of 5
Posted 10 days ago
Travelocity Verified Review
"Host went above and beyond to make our anniversary stay special. Cabin is always welcoming and homey."
A verified traveler stayed at Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness
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