Explore top 2026 4 Star Hotels in Panama Canal Zone
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Top Panama Canal Zone 4 Star hotels
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
$133 nightly
The price is $146 total per night from Jun 15 to Jun 16
$146 total
Jun 15 - Jun 16
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool, onsite laundry facilities, and babysitting. ...
8.6/10 Excellent! (2,560 reviews)
"Nice modern hotel across the road from the airport."
Reviewed on May 21, 2026
Waymore Hotel Spa & Casino
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $98 total per night from May 23 to May 24
$98 total
May 23 - May 24
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
8.8/10 Excellent! (932 reviews)
"It was nice and clean. Staff friendly and helpful."
Reviewed on May 21, 2026
Radisson Hotel Panama Canal
Amador Avenue & Van Hook Street Panama City Panama
$86 nightly
The price is $94 total per night from May 28 to May 29
$94 total
May 28 - May 29
Total with taxes and fees
This smoke-free hotel features 2 restaurants, 2 outdoor pools, and a gym. Families will appreciate the children's pool and onsite laundry facilities. Unwind ...
Courtyard by Marriott Panama Multiplaza Mall
Via Israel Multiplaza Pacific Mall Panama City Panama
$110 nightly
The price is $121 total per night from May 30 to May 31
$121 total
May 30 - May 31
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
9/10 Wonderful! (1,004 reviews)
"Staff at front desk was most helpful and friendly. Kudos to Francisco. He was very welcoming and accommodating."
Reviewed on May 21, 2026
Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from May 29 to May 30
$153 total
May 29 - May 30
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
9/10 Wonderful! (1,023 reviews)
"We arrived about 2 hours before check in time but they were so accommodating and immediately gave us a room. Starting with the bellhop who directed us to the lobby which was in the 5th floor (unusual) who ss soon ss he found out that we were going to leave st 5 AM to another adventure, he ordered ..."
Reviewed on May 20, 2026
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $134 total per night from Jun 7 to Jun 8
$134 total
Jun 7 - Jun 8
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...
7.8/10 Good! (1,000 reviews)
"The room never went clean they only change towels and fixie the bed, even they get in side of the room with outorization , and tell my girlfriend that was sleeping , if she can leave the room for then to clean, next day she lock the door and they still trying go in with maintenance guy to open the ..."
Reviewed on May 21, 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Via Israel y Calle 71, San Francisco Panama City Panama
$102 nightly
The price is $112 total per night from May 29 to May 30
$112 total
May 29 - May 30
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.6/10 Exceptional! (1,204 reviews)
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Reviewed on May 20, 2026
American Trade Hotel
Plaza Herrera Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
$260 nightly
The price is $286 total per night from Jun 1 to Jun 2
$286 total
Jun 1 - Jun 2
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, ...
9.4/10 Exceptional! (740 reviews)
"Fantastic location in the heart of Casco Veijo. Easy to walk around and lots of food options closeby. The hotel dining room menu and coffee shop is excellent! Loved all the amenities. Rooftop pool was fabulous. Each & every staff member was friendly and willing to help."
Reviewed on May 21, 2026
Sheraton Grand Panama
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $139 total per night from May 29 to May 30
$139 total
May 29 - May 30
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
8.6/10 Excellent! (1,006 reviews)
"Very well maintained and beautiful place."
Reviewed on May 21, 2026
Studio Coliving
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
7.8/10 Good! (590 reviews)
"Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here"
Reviewed on Mar 26, 2026
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
4 Star Hotels Panama Canal Zone
Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?
Come on, you deserve it!
The best part about staying in Panama Canal Zone 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.
Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.
The best four star hotels in Panama Canal Zone will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!
If you’re looking for 4 star hotels in Panama Canal Zone, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.
Recent Panama Canal Zone hotel reviews by fellow wanderers
Plaza Paitilla Inn Hotel
4 out of 5
Posted 6 hours ago
Travelocity Verified Review
"When traveling in Panama, I'm thankful for a hotel that doesn't smell musty. I am so sensitive to smells and so many hotels have their "signature scent" piped in a cause migraines for me. I am thrilled to say that Hotel Paitilla smelled fresh and clean. It also offered the most beautiful view of the ocean inlet. It was also quite quiet to our pleasant surprise. We will be staying at Hotel Paitilla again when we visit downtown. By the way, the buffet breakfast was super yummy."
A verified traveler stayed at Plaza Paitilla Inn Hotel
