Explore top 2026 4 Star Hotels in Upstate South Carolina

Name: Hotel Domestique
Price range: $415 total

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Top Upstate South Carolina 4 Star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

44 EAST CAMPERDOWN WAY Greenville SC

Fully refundableReserve now, pay when you stay

$298 nightly

$327 total

Mar 1 - Mar 2

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...

9.6/10 Exceptional! (458 reviews)

Best hotel in the city (no doubt) located perfect, and the hotel decor is amazing which means it has everything for a 5 star hotel experience except the pool, and the service, the service was this times absolutely better than previous but still need more to get to the 5 star service

Reviewed on Feb 26, 2026

The Westin Poinsett Greenville

120 South Main St Greenville SC

Fully refundableReserve now, pay when you stay

$189 nightly

$208 total

Mar 1 - Mar 2

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...

9.2/10 Wonderful! (1,000 reviews)

A dream come true since I was young to stay here. It truly was a lovely Christmas Eve.

Reviewed on Feb 6, 2026

The Shepherd Hotel Downtown Clemson

110 Sloan St Clemson SC

Fully refundableReserve now, pay when you stay

$219 nightly

$243 total

Mar 15 - Mar 16

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...

9.8/10 Exceptional! (763 reviews)

All was excellent

Reviewed on Feb 23, 2026

Hotel Hartness

120 Halston Avenue Greenville SC

Fully refundableReserve now, pay when you stay

$182 nightly

$200 total

Mar 8 - Mar 9

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...

9.8/10 Exceptional! (659 reviews)

very nice

Reviewed on Feb 28, 2026

Greenville Marriott

One Parkway E Greenville SC

Fully refundableReserve now, pay when you stay

$122 nightly

$134 total

Mar 8 - Mar 9

Total with taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, ...

8.6/10 Excellent! (628 reviews)

Room was very nice. I was charged twice for my stay even though I paid online and it took almost 7 days to refund my money after they finally realized the oversight!

Reviewed on Feb 24, 2026

Mint House Greenville - Downtown

101 Falls Park Dr Greenville SC

$111 nightly

$123 total

Mar 15 - Mar 16

Total with taxes and fees

A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.

9.2/10 Wonderful! (797 reviews)

I had an overall positive experience during my stay. The check-in process was seamless and straightforward, which made arriving stress-free. I also appreciated how easy it was to access customer service whenever I needed assistance. The space itself was clean, well-maintained, and very comfortable. ...

Reviewed on Feb 27, 2026

The Abernathy of Clemson

157 Old Greenville Hwy Clemson SC

Fully refundableReserve now, pay when you stay

$169 nightly

$188 total

Mar 2 - Mar 3

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...

9.6/10 Exceptional! (567 reviews)

Great staff. Very friendly. Very clean.

Reviewed on Feb 15, 2026

Park Place Apartments by Landing

31 Victor St Greenville SC

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A 24-hour gym and a virtual front desk are also provided.

7.6/10 Good! (46 reviews)

The facility is beautiful, but there is no visibility of staff. We had several mechanical issues with dishwasher, washing machine and the Internet. We were able to resolve the Internet issue. But the dishwasher was never fixed during the four nights we stayed and our clothes. Locked in the washer. ...

Reviewed on Jan 14, 2026

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The Station by Compo Hotels

745 Old Buncombe Rd Travelers Rest SC

$287 nightly

$316 total

Mar 3 - Mar 4

Total with taxes and fees

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Barbecue grills are provided for your convenience.

10/10 Exceptional! (17 reviews)

The room was so spacious, clean, and peaceful! If you are stopping in SC, near Travelers Rest, I highly recommend staying here. I was on a work trip and this place felt like a little hide away to get the rest I needed!

Reviewed on Feb 25, 2026

Hotel Domestique

10 Road of Vines Travelers Rest SC

$377 nightly

$415 total

Mar 1 - Mar 2

Total with taxes and fees

This hotel features a restaurant, an outdoor tennis court, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like cooked-to-order breakfast and ...

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4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Hotel Hartness

5 out of 5

Posted 2 days ago

Travelocity Verified Review

"The hotel had a wonderful smell when you walk in. They have very high-end lotions and hair products. Great lighting getting ready. Great lighting for reading. Overall the hotel was a 10 in my opinion."

A verified traveler stayed at Hotel Hartness