Explore top 2026 4 Star Hotels in Upstate South Carolina

Name: Hotel Domestique
Price range: $272 total
Rating: 9.6

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Top Upstate South Carolina 4 Star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

44 EAST CAMPERDOWN WAY Greenville SC

Fully refundableReserve now, pay when you stay

$235 nightly

$259 total

Feb 1 - Feb 2

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...

9.4/10 Exceptional! (434 reviews)

Lovely property in the heart of downtown Greenville. Rooms are spacious and well appointed, we found beds to be rather soft and not very supportive. We had a partial view of the river and Falls Park. The hotel has several solaces dedicated to artwork, a restaurant and bar. Good was fine. We were ...

Reviewed on Jan 7, 2026

The Westin Poinsett Greenville

120 South Main St Greenville SC

Fully refundableReserve now, pay when you stay

$179 nightly

$197 total

Jan 25 - Jan 26

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...

9.2/10 Wonderful! (1,009 reviews)

Yes the bar & the staff that worked at mid shift were excellent. The breakfast & presentation with the staff coordination exceeded my expectations...

Reviewed on Jan 2, 2026

The Shepherd Hotel Downtown Clemson

110 Sloan St Clemson SC

Fully refundableReserve now, pay when you stay

$179 nightly

$199 total

Jan 18 - Jan 19

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...

9.8/10 Exceptional! (747 reviews)

Beautiful hotel. Great service. Delicious food.

Reviewed on Jan 8, 2026

Hotel Hartness

120 Halston Avenue Greenville SC

Fully refundableReserve now, pay when you stay

$199 nightly

$219 total

Jan 11 - Jan 12

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...

9.8/10 Exceptional! (635 reviews)

I cannot say enough nice things about this stay! The thermostat was not working in my room and they immediately offered to put me in a different room or bring me a fan. Everyone that I encountered was very friendly!

Reviewed on Dec 31, 2025

Greenville Marriott

One Parkway E Greenville SC

Fully refundableReserve now, pay when you stay

$105 nightly

$116 total

Jan 24 - Jan 25

Total with taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, ...

8.4/10 Very Good! (613 reviews)

Bed was SO comfortable, I slept all through the night!!! Staff incredible especially the girls at breakfast and Adam at the bar.

Reviewed on Dec 19, 2025

Mint House Greenville - Downtown

101 Falls Park Dr Greenville SC

A 24-hour gym, self parking, and laundry facilities are featured at this apartment. Express check-in and express check-out are also provided.

9.2/10 Wonderful! (785 reviews)

The check in process was rough, terrible! It would help to have someone on site for questions. Couldn’t get in the building because my room number was incorrect in the written check in instructions. Please be a lot clearer in the check in process. It was very confusing! It would help if you send ...

Reviewed on Jan 3, 2026

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The Abernathy of Clemson

157 Old Greenville Hwy Clemson SC

$163 nightly

$181 total

Feb 8 - Feb 9

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...

9.6/10 Exceptional! (560 reviews)

everything was good

Reviewed on Dec 25, 2025

Park Place Apartments by Landing

31 Victor St Greenville SC

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A 24-hour gym and a virtual front desk are also provided.

7.6/10 Good! (44 reviews)

This is an extended stay type of apartment - not a hotel. No front desk. When I arrived - there was not a key to get into the building. It was supposed to be in a lockbox outside but that was open and empty! You have to walk up at least one flight of stairs - not ideal for an extended stay where ...

Reviewed on Dec 4, 2025

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The Station by Compo Hotels

745 Old Buncombe Rd Travelers Rest SC

$251 nightly

$277 total

Jan 11 - Jan 12

Total with taxes and fees

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Barbecue grills are provided for your convenience.

10/10 Exceptional! (16 reviews)

Tracee was so kind and helpful. The

Reviewed on Jan 1, 2026

Hotel Domestique

10 Road of Vines Travelers Rest SC

$248 nightly

$272 total

Jan 11 - Jan 12

Total with taxes and fees

This hotel features a restaurant, an outdoor tennis court, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like cooked-to-order breakfast and ...

9.6/10 Exceptional! (31 reviews)

Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away.

Reviewed on Jul 27, 2025

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4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Upstate South Carolina hotel reviews by fellow wanderers

Hyatt Regency Greenville

5 out of 5

Posted 2 days ago

Travelocity Verified Review

"Great"

A verified traveler stayed at Hyatt Regency Greenville

Homewood Suites by Hilton Greenville Downtown

5 out of 5

Posted 4 days ago

Travelocity Verified Review

"We enjoyed our stay very much. The front desk staff was welcoming and accommodating to our special requests. Our room was spacious, clean and quiet and the beds were comfortable. We also enjoyed seeing the sunset over the mountains out of our bedroom window. Will definitely recommend and keep in mind for our future needs. One of the best experiences we have had staying at a hotel. "

A verified traveler stayed at Homewood Suites by Hilton Greenville Downtown