Explore top 2025 4 Star Hotels in Upstate South Carolina

Name: The Station by Compo Hotels
Price range: $301 total
Rating: 10

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Top Upstate South Carolina 4 Star hotels

Grand Bohemian Lodge Greenville, Autograph Collection

44 EAST CAMPERDOWN WAY, Greenville, SC

$297 nightly

$327 total

Oct 26 - Oct 27

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free ...

9.4/10 Exceptional! (389 reviews)

"What a fabulous hotel. Great location, super clean, and the most helpful staff."

Reviewed on Sep 29, 2025

The Shepherd Hotel Downtown Clemson

110 Sloan St, Clemson, SC

$189 nightly

$210 total

Oct 19 - Oct 20

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...

9.6/10 Exceptional! (690 reviews)

"Love this hotel - far superior than any other hotel in the area"

Reviewed on Sep 30, 2025

The Westin Poinsett Greenville

120 South Main St, Greenville, SC

$209 nightly

$230 total

Nov 2 - Nov 3

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...

9.2/10 Wonderful! (1,001 reviews)

"Very courteous and helpful staff"

Reviewed on Oct 4, 2025

Mint House Greenville - Downtown

101 Falls Park Dr, Greenville, SC

$153 nightly

$168 total

Oct 19 - Oct 20

Total with taxes and fees

A 24-hour gym is featured at this apartment, along with express check-in and express check-out. Laundry facilities are provided for your convenience.

9.2/10 Wonderful! (740 reviews)

"Parking a little bit tough. All else is great."

Reviewed on Sep 30, 2025

Hotel Hartness

120 Halston Avenue, Greenville, SC

Fully refundableReserve now, pay when you stay

$209 nightly

$230 total

Oct 12 - Oct 13

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...

9.6/10 Exceptional! (597 reviews)

"Loved the spa treatments and pool area for relaxing. Pattersons restaurant was a disappointment this time. Last summer the dinner choices were more to my liking. This time my group of 8 diners had a hard time choosing something they wanted and not one of the 4 of us that choose the shrimp entree ..."

Reviewed on Sep 30, 2025

Greenville Marriott

One Parkway E, Greenville, SC

$126 nightly

$138 total

Oct 26 - Oct 27

Total with taxes and fees

This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, ...

8.4/10 Very Good! (596 reviews)

"The only negative is that they don't have free wi-fi in the rooms anymore. Otherwise, its always a great stay any time we're in Greenville. Good restaurant and shuttle service are an important and appreciated bonus."

Reviewed on Oct 2, 2025

The Abernathy of Clemson

157 Old Greenville Hwy, Clemson, SC

$135 nightly

$150 total

Nov 5 - Nov 6

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...

9.6/10 Exceptional! (544 reviews)

"Clean room, great staff, location and parking and the bartender"

Reviewed on Sep 28, 2025

Park Place Apartments by Landing

300 Hammett St, Greenville, SC

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A gym and a virtual front desk are also provided.

7.6/10 Good! (40 reviews)

"Great access to bike trail. No working elevator and 3 flights of stairs with luggage is a challenge."

Reviewed on Jun 19, 2025

Get rates

The Station by Compo Hotels

745 Old Buncombe Rd, Travelers Rest, SC

$273 nightly

$301 total

Nov 5 - Nov 6

Total with taxes and fees

This aparthotel doesn't skimp on freebies - guests receive free WiFi and free self parking. Barbecue grills are provided for your convenience.

10/10 Exceptional! (12 reviews)

"This is my third time staying at the station and it didn’t disappoint! I love the comfy beds and the green space around the rooms. What a beautiful area!"

Reviewed on Jul 26, 2025

Liberty Hall Bed and Breakfast

621 S Mechanic St, Pendleton, SC

$179 nightly

$198 total

Oct 15 - Oct 16

Total with taxes and fees

This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express ...

9.8/10 Exceptional! (74 reviews)

"Excellent property with spacious rooms and a great front porch with rocking chairs to relax in. Fabulous breakfast every day. But most important was the staff. Angela and Micheal were very welcoming and ready to help with anything you might need. Would definitely return."

Reviewed on Sep 2, 2025

Don't see what you're looking for?

See all available properties in Upstate South Carolina

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Upstate South Carolina

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Upstate South Carolina 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Upstate South Carolina will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Upstate South Carolina, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.