Explore top 2026 4 Star Hotels in Central Missouri

Name: Lakefront & Boat Slip: Osage Beach Retreat!
Rating: 10

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Top Central Missouri 4 Star hotels

Lodge Of Four Seasons Golf Resort, Marina & Spa

315 Four Seasons Dr. Lake Ozark MO

Fully refundableReserve now, pay when you stay

$136 nightly

$149 total

Sep 1 - Sep 2

Total with taxes and fees

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, ...

Drury Plaza Hotel Columbia East

3100 Interstate 70 Dr. SE Columbia MO

Fully refundableReserve now, pay when you stay

$94 nightly

$106 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...

The Broadway Columbia - a DoubleTree by Hilton

1111 E Broadway Columbia MO

Fully refundableReserve now, pay when you stay

$130 nightly

$148 total

Aug 28 - Aug 29

Total with taxes and fees

This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet ...

Camden on the Lake Resort & Spa

2359 Bittersweet Road Lake Ozark MO

$158 nightly

$168 total

Sep 7 - Sep 8

Total with taxes and fees

This smoke-free resort features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the free WiFi in public areas and free ...

9.2/10 Wonderful! (1,003 reviews)

"Loved this hotel. We didn't spend much time there, but we were always happy to arrive in the evening. The room was beautiful and comfortable. The staff was very friendly and professional. The hotel felt like it was located on the furthest end. Everything we wanted to do was a 15-20 minute ride (but ..."

Reviewed on Aug 13, 2026

voco The Tiger Hotel Columbia, MO by IHG

23 S 8th St Columbia MO

Fully refundable

$162 nightly

$184 total

Sep 6 - Sep 7

Total with taxes and fees

A nightclub, 4 restaurants, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center, ...

9/10 Wonderful! (1,000 reviews)

"When I arrived at the hotel I was a little early for check in after a long early flight the Missouri. I was not able to check in early so was directed to the restaurant where everyone was friendly. Once I was done eating, I went back to the check in and my room still was not ready. I was desperate ..."

Reviewed on Aug 8, 2026

DoubleTree by Hilton Hotel Jefferson City

422 Monroe St Jefferson City MO

Fully refundableReserve now, pay when you stay

$122 nightly

$140 total

Sep 3 - Sep 4

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and WiFi in public areas. ...

8.4/10 Very Good! (763 reviews)

"This is the only place to stay in Jeff City as far as I'm concerned. This place has a pool and fitness center, the rooms are very nice. 2 blocks to the main street. I will stay nowhere else. It's not that I've had bad experiences but this one has everything you need"

Reviewed on Aug 13, 2026

Breakwater Bay Condo for Shootout Weekend Crews

Osage Beach MO

This apartment doesn't skimp on freebies - guests receive free WiFi and free self parking. An outdoor pool is also provided.

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Indian Pointe Lake View Pets!

831 Indian Pointe, Osage Beach, Osage Beach MO

Free WiFi in public areas is available at this condo.

10/10 Exceptional! (1 review)

"Awesome view, easy parking, clean and comfortable! Definitely a good spot to stay."

Reviewed on Feb 26, 2026

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Lakefront & Boat Slip: Osage Beach Retreat!

Osage Beach MO

A marina and an outdoor pool are featured at this smoke-free apartment. Guests will appreciate free perks like free self parking and WiFi in public areas. Barbecue ...

10/10 Exceptional! (1 review)

"Beautiful place! Not hard to find at all! Very nice owners"

Reviewed on Apr 7, 2025

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4 Star Hotels Central Missouri

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Central Missouri 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Central Missouri will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Central Missouri, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.