Southern Illinois Vacation Packages 2026 from $404

Southern Illinois flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$404

per person

Mar 9 - Mar 12

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Spacious 3-Bedroom with King Bed

Central West End

Save 100% on your flight

$925

per person

Mar 26 - Mar 29

found 1 day ago

Roundtrip flight included

Minneapolis (MSP) to St. Louis (STL)

This apartment doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, laundry facilities, and a virtual front desk are also on offer.

Comfort Suites Rolla

$738

per person

Mar 8 - Mar 14

found 4 hours ago

Roundtrip non-stop flight included

Minneapolis (MSP) to St. Louis (STL)

This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.

The Knight Center at Washington University

$526

per person

Mar 9 - Mar 12

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Self parking and a coffee shop are also offered on site.

Hampton Inn By Hilton St Louis Airport

Woodson Terrace

$477

per person

Mar 9 - Mar 12

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

Self parking is available and the hotel's front desk is staffed around-the-clock. Guests will appreciate freebies like continental breakfast, WiFi in public areas, and a roundtrip airport shuttle. Express check-in and express check-out are also provided.

Top Southern Illinois hotels deals

Drury Plaza Hotel Mt. Vernon

145 North 44th Street Mount Vernon IL

Free Cancellation

Reserve now, pay when you stay

$94 nightly

$106 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

Free Cancellation

Reserve now, pay when you stay

$44 nightly

$51 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like on-the-go breakfast and free self parking.

Pool

Breakfast included

Drury Inn & Suites St. Louis Fairview Heights

12 Ludwig Dr Fairview Heights IL

Free Cancellation

Reserve now, pay when you stay

$94 nightly

$106 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Drury Inn & Suites St. Louis O'Fallon, IL

1118 Central Park Drive O'Fallon IL

Free Cancellation

Reserve now, pay when you stay

$106 nightly

$123 total

Jan 4 - Jan 5, 2026

Total with taxes and fees

Pool

Hot Tub

Comfort Suites Mount Vernon

404 South 44th Street Mount Vernon IL

Free Cancellation

Reserve now, pay when you stay

$109 nightly

$123 total

Dec 30 - Dec 31

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and free perks like buffet breakfast and free self parking.

Pool

Hot Tub

Drury Inn & Suites Marion

2706 W DeYoung St Marion IL

Free Cancellation

Reserve now, pay when you stay

$65 nightly

$78 total

Jan 5 - Jan 6, 2026

Total with taxes and fees

Pool

Hot Tub

Don't see what you're looking for?

See all available properties in Southern Illinois

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Southern Illinois University

4.5/5(173 reviews)

Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

Garden of the Gods Recreation Area

5/5(6 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

Superman Statue

4.5/5(104 reviews)

Superman fans will love getting a photograph taken in front of this giant statue of the Man of Steel himself, dressed in his iconic red-and-blue guise.

Frequently asked questions

How much are vacation packages to Southern Illinois?

Your travel fantasies can become a reality in Southern Illinois for as little as $404. Our package deals include flights and hotels, so booking your trip will be a piece of cake. The only thing you'll need to worry about is what amazing attraction you'll head to first.

Where can I get the best vacation package deals for Southern Illinois?

With at least 400 air carriers and 1,000,000 properties around the world, it's tough to beat Travelocity. Take advantage of our comprehensive range and grab an affordable Southern Illinois vacation package. Doesn't it feel amazing when travel is that easy?

Why should I purchase my Southern Illinois vacation package via Travelocity?

The three S's — savings, support and a stress-free booking — are just the beginning. Enjoy a fulfilling travel experience knowing you can rely on our expert team of customer support professionals 24/7. With the Travelocity Price Match Guarantee, you can rest easy knowing you're getting the best deal available.

Can I save on my Southern Illinois car rental if I bundle it with a hotel or flight?

You can with our Southern Illinois vacation packages. With one of these, there are lots of ways to stretch your budget further. Combine any two or more car, flight, hotel and tour bookings and watch the savings start to pile up. With your own set of wheels, all the landmarks around Southern Illinois are just a road trip away.

Which airport is best for Southern Illinois?

Williamson County Regional Airport (MWA) is the main airport that offers flights in and out of Southern Illinois.

What is there to do in Southern Illinois?

Southern Illinois boasts hidden gems at every turn, however make sure you see Shawnee National Forest and Southern Illinois University while you're in town. These two attractions are popular with visitors.