Book Hotels in Six Mile, SC
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Top Six Mile hotels

The Shepherd Hotel Downtown Clemson
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $221 total per night from Apr 14 to Apr 15
$221 total
Apr 14 - Apr 15
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
hotel was great, modern, clean gorgeous
Reviewed on Apr 7, 2026

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
299 Outpost Rd Seneca SC
$133 nightly
The price is $146 total per night from May 10 to May 11
$146 total
May 10 - May 11
Total with taxes and fees
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
Great spot for couples wanting to connect or a solo trip.
Reviewed on Apr 2, 2026

The Inn at Patrick Square
115 Market Street Clemson SC
$159 nightly
The price is $176 total per night from Apr 12 to Apr 13
$176 total
Apr 12 - Apr 13
Total with taxes and fees
A 24-hour gym is featured at this hotel, along with free self parking. WiFi in public areas is free. Staff at the 24-hour front desk can provide around-the-clock ...
Very nice hotel - very clean, beautiful decor.
Reviewed on Apr 9, 2026

Lake Keowee Lakefront Cove, Private Dock, Boat Parking, Kayaks & more
Six Mile SC
This vacation home features a garden, laundry facilities, and barbecue grills.
Check in was great the host was very helpful in answering all questions. Very clean very satisfied with the stay quiet area away from lake traffic.
Reviewed on Apr 7, 2026

Clemson University's James F. Martin Inn
240 Madren Center Drive Clemson SC
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $165 total per night from Apr 12 to Apr 13
$165 total
Apr 12 - Apr 13
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center ...
Wasn’t convenient to town or university Convenient to visitor center and convention center only.
Reviewed on Apr 8, 2026

Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Apr 12 to Apr 13
$135 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Enjoy the seasonal outdoor pool and perks like free self parking and free WiFi. You'll appreciate ...
Overall very nice, only three significant issues… 1) Road noise on pool and patio is tremendous and distracting. 2) The hotel closes the pool and jacuzzi at dark, which combined with the road noise kind of makes those facilities of limited value. 3) The hotel has nice fire pits, but the big lights ...
Reviewed on Apr 6, 2026

Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Apr 12 to Apr 13
$112 total
Apr 12 - Apr 13
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
standard hotel and amenities, all that was needed
Reviewed on Apr 8, 2026

Comfort Inn & Suites Clemson - University Area
1305 Tiger Blvd Clemson SC
Fully refundable
$105 nightly
The price is $117 total per night from May 10 to May 11
$117 total
May 10 - May 11
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
We were told checkout was 11am but that didn’t stop the cleaning lady from kicking our door open at 8:30am on a Tuesday “just to see if anyone was still in the room.” She did it a second time an hour later, just as my daughter was preparing to get into the shower. I yelled at cleaning lady to stop ...
Reviewed on Apr 9, 2026

Days Inn by Wyndham Anderson
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $65 total per night from Apr 12 to Apr 13
$65 total
Apr 12 - Apr 13
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
We live in Atlanta but come down to hang with family at lake hartwell great place to stay always clean and quiet highly recommend.
Reviewed on Apr 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Six Mile hotel reviews by fellow wanderers

Comfort Inn & Suites Clemson - University Area
2 out of 5
Posted 10 hours ago
Travelocity Verified Review
"We were told checkout was 11am but that didn’t stop the cleaning lady from kicking our door open at 8:30am on a Tuesday “just to see if anyone was still in the room.” She did it a second time an hour later, just as my daughter was preparing to get into the shower. I yelled at cleaning lady to stop entering our room, and she said “the door was already open” while giving me a dirty look, then slammed the door shut. Ridiculous behavior, we won’t stay here a second time."
A verified traveler stayed at Comfort Inn & Suites Clemson - University Area
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