Book Hotels in Six Mile, SC
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Top Six Mile hotels

Lake Keowee Lakefront Cove, Private Dock, Boat Parking, Kayaks & more
Six Mile SC
This vacation home features a garden, laundry facilities, and barbecue grills.
"Clean and well appointed."
Reviewed on Oct 29, 2026

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
299 Outpost Rd Seneca SC
$133 nightly
The price is $146 total per night from Dec 13 to Dec 14
$146 total
Dec 13 - Dec 14
Total with taxes and fees
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreation Area and Cross Creek Plantation Golf ...
"We enjoyed the property, but was not the easiest to find after going around the loop and following the “one way” signs"
Reviewed on Nov 7, 2026

Days Inn by Wyndham Anderson
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $65 total per night from Nov 24 to Nov 25
$65 total
Nov 24 - Nov 25
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Nothing"
Reviewed on Nov 14, 2026

Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Nov 30 to Dec 1
$112 total
Nov 30 - Dec 1
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"😊😊😊"
Reviewed on Nov 14, 2026

Quality Inn Seneca US-123
226 Hi Tech Rd Seneca SC
Fully refundable
$86 nightly
The price is $94 total per night from Dec 1 to Dec 2
$94 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
"Front Desk was extremely friendly & check in was quick. Room was nice....had coffee maker, refrigerator. Hotel was very convenient to fast food & restaurants."
Reviewed on Nov 14, 2026

Rustic Lake Keowee Cabin, Perfect for Couples! Dock, Pool & Boat Slip
Six Mile SC
An outdoor pool is featured at this cabin, along with laundry facilities and barbecue grills.

Clemson University's James F. Martin Inn
240 Madren Center Drive Clemson SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $154 total per night from Nov 30 to Dec 1
$154 total
Nov 30 - Dec 1
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center ...

Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Nov 15 to Nov 16
$135 total
Nov 15 - Nov 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Enjoy the seasonal outdoor pool and perks like free self parking and free WiFi. You'll appreciate ...

Inn @ Clemson
1303 Tiger Blvd Clemson SC
$74 nightly
The price is $82 total per night from Nov 16 to Nov 17
$82 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Six Mile hotel reviews by fellow wanderers

Quality Inn Seneca US-123
5 out of 5
Posted 6 hours ago
Travelocity Verified Review
"Front Desk was extremely friendly & check in was quick. Room was nice....had coffee maker, refrigerator. Hotel was very convenient to fast food & restaurants."
A verified traveler stayed at Quality Inn Seneca US-123
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