Book Hotels in Six Mile, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Six Mile hotels

LAKE KEOWEE WATERFRONT! ONLY 15 feet from Shore. Price includes BOAT SLIP

LAKE KEOWEE WATERFRONT! ONLY 15 feet from Shore. Price includes BOAT SLIP

Six Mile SC
$412 nightly
The price is $457 total per night from Jul 26 to Jul 27
$457 total
Jul 26 - Jul 27
Total with taxes and fees
This chalet features laundry facilities.
"We came in for a concert at Clemson. This location was very close. The price was perfect especially since everyone else jacked their prices sky high for the event. Communication was great! The condo was very cute and right on the water."

Reviewed on Jul 1, 2026

Opens in a new windowLAKE KEOWEE WATERFRONT! ONLY 15 feet from Shore. Price includes BOAT SLIP
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd Clemson SC
Fully refundable
$101 nightly
The price is $112 total per night from Aug 23 to Aug 24
$112 total
Aug 23 - Aug 24
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"Great cheaper options for families complete with free breakfast. The hotel is on the older side and it’s not as up to date, but it’s a great option if you don’t want to break the bank. It’s cheaper than similar options that are more up to date. So we always choose to just stay here instead since ..."

Reviewed on Jul 25, 2026

Opens in a new windowComfort Inn & Suites Clemson - University Area
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $122 total per night from Jul 28 to Jul 29
$122 total
Jul 28 - Jul 29
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Great location near Clemson University"

Reviewed on Jul 25, 2026

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $67 total per night from Aug 2 to Aug 3
$67 total
Aug 2 - Aug 3
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Room was good, ice maker broken and toilet was clogged upon check in and no one from maintenence was available so I had to plunge the toilet."

Reviewed on Jul 25, 2026

Opens in a new windowDays Inn by Wyndham Anderson
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $173 total per night from Jul 28 to Jul 29
$173 total
Jul 28 - Jul 29
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
Opens in a new windowThe Shepherd Hotel Downtown Clemson
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Jul 26 to Jul 27
$135 total
Jul 26 - Jul 27
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Enjoy the seasonal outdoor pool and perks like free self parking and free WiFi. You'll appreciate ...
Opens in a new windowLakeside Lodge Clemson
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
Fully refundable
$88 nightly
The price is $96 total per night from Jul 30 to Jul 31
$96 total
Jul 30 - Jul 31
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...
Opens in a new windowQuality Inn Seneca Clemson Area US-123
Courtyard Marriott Clemson

Courtyard Marriott Clemson

3 out of 5
201 Canoy Ln Clemson SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Aug 9 to Aug 10
$135 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Relax ...
Opens in a new windowCourtyard Marriott Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
$124 nightly
The price is $136 total per night from Aug 24 to Aug 25
$136 total
Aug 24 - Aug 25
Total with taxes and fees
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
Opens in a new windowPostcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Don't see what you're looking for?
See all available properties in Six Mile
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Where can I find cheap hotels in Six Mile?
At Travelocity you'll find really nice hotels in Six Mile at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Six Mile rather than in Six Mile. We may find you even better rates, too.
How do I find the best Six Mile hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Six Mile then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Six Mile?
The cheapest hotel in Six Mile is $67. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Six Mile?
There are 1,555 hotels in Six Mile on Travelocity.
What are the best hotels in Six Mile?
Six Mile has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Six Mile for you!
When is the best time to visit Six Mile?
If you want the joy of a fun-filled trip in peak season, visit Six Mile during March, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as October, November and December.
When is the cheapest time to stay in Six Mile?
Based on historic data is usually the cheapest month to visit Six Mile. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Six Mile?
There are multiple hotels in Six Mile that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Six Mile. We have plenty of kid-friendly hotels in Six Mile to choose from on Travelocity!
Why book a hotel in Six Mile through Travelocity?
Because we have the top hotels in Six Mile! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Six Mile on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Six Mile hotel reviews by fellow wanderers

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

5 out of 5
Posted 4 hours ago
Travelocity Verified Review
"Great view of the lake, comfortable beds great pillows"
A verified traveler stayed at Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area

Explore More Ways to Travel with Travelocity