Book Hotels in Six Mile, SC

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Six Mile hotels

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $169 total per night from Jul 13 to Jul 14
$169 total
Jul 13 - Jul 14
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
"Very nice upscale hotel. Bed was very comfortable. Only complaint was there is not gym and no in room coffee maker. Otherwise and nice hotel in walking distance to Clemson."

Reviewed on Jul 11, 2026

Opens in a new windowThe Shepherd Hotel Downtown Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
$133 nightly
The price is $146 total per night from Aug 10 to Aug 11
$146 total
Aug 10 - Aug 11
Total with taxes and fees
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
"Road in was really rough, can't imagine what it's like in rain. We made it up the hill in minivan but it was touch and go for a few"

Reviewed on Jul 8, 2026

Opens in a new windowPostcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

3 out of 5
240 Madren Center Drive Clemson SC
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $160 total per night from Jul 12 to Jul 13
$160 total
Jul 12 - Jul 13
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the 24-hour business center ...
"Nice hotel in a peaceful setting with everything you need (restaurant, starbucks, gym, and pool)."

Reviewed on Jul 10, 2026

Opens in a new windowClemson University's James F. Martin Inn
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $135 total per night from Jul 12 to Jul 13
$135 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Enjoy the seasonal outdoor pool and perks like free self parking and free WiFi. You'll appreciate ...
"Great pool area, good location."

Reviewed on Jul 11, 2026

Opens in a new windowLakeside Lodge Clemson
Courtyard Marriott Clemson

Courtyard Marriott Clemson

3 out of 5
201 Canoy Ln Clemson SC
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $149 total per night from Jul 19 to Jul 20
$149 total
Jul 19 - Jul 20
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center and free WiFi in public areas. Relax ...
"The room was great! Staff was extremely polite and helpful. Unfortunately the cost for a night during and event in town, the room was priced 4x's the regular rate, that's my only complaint."

Reviewed on Jun 29, 2026

Opens in a new windowCourtyard Marriott Clemson
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd Clemson SC
Fully refundable
$107 nightly
The price is $119 total per night from Jul 20 to Jul 21
$119 total
Jul 20 - Jul 21
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests ...
"Front desk staff were polite and accommodating. Room was immaculate and the matresses were the perfect “Goldilocks” level of firmness. Only beef was my bathtub drain plug got stuck so my morning shower turned into a bath. No huge deal. Convenient and affordable digs. I’d stay there again."

Reviewed on Jul 8, 2026

Opens in a new windowComfort Inn & Suites Clemson - University Area
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $106 total per night from Jul 12 to Jul 13
$106 total
Jul 12 - Jul 13
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Room was clean as taff was nice our bathroom pipes were making sounds in the room so they let us Change rooms with no issues. The new girl at the front desk was new and very kind but charged us after we had reservation with Expedia but that is being credited to us. Expedia helped in that situation. ..."

Reviewed on Jul 10, 2026

Opens in a new windowBest Western Plus Clemson Hotel & Conference Center
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $65 total per night from Jul 13 to Jul 14
$65 total
Jul 13 - Jul 14
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"I booked a hotel room through the Expedia website and paid for one night. I checked in, but I didn't stay in the room for more than five minutes because it was disgusting. There was hair everywhere and trash piled up behind the beds, as if the room hadn't been cleaned in months. I immediately went ..."

Reviewed on Jul 8, 2026

Opens in a new windowDays Inn by Wyndham Anderson
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $91 total per night from Jul 13 to Jul 14
$91 total
Jul 13 - Jul 14
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Clean and comfortable stay."

Reviewed on Jul 9, 2026

Opens in a new windowInn @ Clemson
Don't see what you're looking for?
See all available properties in Six Mile
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Where can I find cheap hotels in Six Mile?
At Travelocity you'll find really nice hotels in Six Mile at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Six Mile rather than in Six Mile. We may find you even better rates, too.
How do I find the best Six Mile hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Six Mile then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Six Mile?
The cheapest hotel in Six Mile is $65. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Six Mile?
There are 1,559 hotels in Six Mile on Travelocity.
What are the best hotels in Six Mile?
Six Mile has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Six Mile for you!
When is the best time to visit Six Mile?
If you want the joy of a fun-filled trip in peak season, visit Six Mile during March, July and August. If you'd prefer the peace of off-season, book a stay during quieter months, such as October, November and December.
When is the cheapest time to stay in Six Mile?
Based on historic data is usually the cheapest month to visit Six Mile. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Six Mile?
There are multiple hotels in Six Mile that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Six Mile. We have plenty of kid-friendly hotels in Six Mile to choose from on Travelocity!
Why book a hotel in Six Mile through Travelocity?
Because we have the top hotels in Six Mile! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Six Mile on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Six Mile hotel reviews by fellow wanderers

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
Posted 21 hours ago
Travelocity Verified Review
"Very nice upscale hotel. Bed was very comfortable. Only complaint was there is not gym and no in room coffee maker. Otherwise and nice hotel in walking distance to Clemson."
A verified traveler stayed at The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson

Explore More Ways to Travel with Travelocity