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Top hotels in Mission Bay

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$241 nightly
The price is $279 total per night from Sep 8 to Sep 9
$279 total
Sep 8 - Sep 9
Total with taxes and fees
This smoke-free hotel includes 6 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in ...
"Outstanding experience. The hotel exceeded expectations in every way. Room was gorgeous and spotless, staff so helpful, and the sushi at the Top of the Hyatt was to die for. I highly recommend!"

Reviewed on Aug 25, 2026

Opens in a new windowManchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$226 nightly
The price is $261 total per night from Sep 13 to Sep 14
$261 total
Sep 13 - Sep 14
Total with taxes and fees
A nightclub, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the 24-hour gym and perks like free WiFi. There's a bar/lounge ...
"Very friendly and quick service."

Reviewed on Aug 26, 2026

Opens in a new windowHard Rock Hotel San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$261 nightly
The price is $300 total per night from Sep 7 to Sep 8
$300 total
Sep 7 - Sep 8
Total with taxes and fees
This smoke-free resort features a full-service spa, a marina, and 3 restaurants. Family-friendly amenities include mini golf and kid-friendly dining, along with ...
"The staff was very friendly and very helpful."

Reviewed on Aug 26, 2026

Opens in a new windowParadise Point Resort & Spa
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
$230 nightly
The price is $264 total per night from Sep 7 to Sep 8
$264 total
Sep 7 - Sep 8
Total with taxes and fees
A full-service spa, 2 restaurants, and 5 outdoor tennis courts are all featured at this Mediterranean resort. There's fun for all ages with a children's pool ...
"Had a very enjoyable time, will definitely return. Which they had more food Venue options."

Reviewed on Aug 26, 2026

Opens in a new windowSan Diego Mission Bay Resort
San Diego Marriott La Jolla

San Diego Marriott La Jolla

4 out of 5
4240 La Jolla Village Dr La Jolla CA
$178 nightly
The price is $204 total per night from Sep 11 to Sep 12
$204 total
Sep 11 - Sep 12
Total with taxes and fees
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
"We had great experience at out stay ."

Reviewed on Aug 26, 2026

Opens in a new windowSan Diego Marriott La Jolla
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd San Diego CA
$225 nightly
The price is $259 total per night from Sep 10 to Sep 11
$259 total
Sep 10 - Sep 11
Total with taxes and fees
This smoke-free hotel features a full-service spa, a marina, and 2 restaurants. Traveling on business? Take advantage of the business center, free WiFi in public ...
"Room was clean and good size"

Reviewed on Aug 26, 2026

Opens in a new windowHyatt Regency Mission Bay Spa and Marina
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $102 total per night from Aug 27 to Aug 28
$102 total
Aug 27 - Aug 28
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Traveling for business? Take advantage of the free WiFi in public areas, express check-out, and conference ...
"This is an amazing place to stay in San Diego, CA. Staff are the go beyond type. They are polite direct about every thing. Just stay here, you'll see what I mean!!"

Reviewed on Aug 26, 2026

Opens in a new windowCalifornia Suites Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$186 nightly
The price is $213 total per night from Sep 9 to Sep 10
$213 total
Sep 9 - Sep 10
Total with taxes and fees
A marina, 2 outdoor pools, and 2 hot tubs are all featured at this smoke-free hotel. If you want to take your pet along, this pet-friendly property offers everything ...
Opens in a new windowThe Dana on Mission Bay
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $202 total per night from Sep 8 to Sep 9
$202 total
Sep 8 - Sep 9
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center and free WiFi in public ...
Opens in a new windowWyndham San Diego Bayside
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mission Bay Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Mission Bay area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Mission Bay to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Mission Bay are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Mission Bay hotel reviews by fellow wanderers

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Very friendly and quick service."
A verified traveler stayed at Hard Rock Hotel San Diego
Hard Rock Hotel San Diego