Book a hotel near Palmdale Regional Medical Center, Palmdale

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Top hotels close to Palmdale Regional Medical Center

DoubleTree by Hilton Palmdale, CA

DoubleTree by Hilton Palmdale, CA

4 out of 5
West Palmdale Boulevard, 300 Palmdale CA
Free Cancellation
Reserve now, pay when you stay
0.65 mi from Palmdale Regional Medical Center
$80 nightly
The price is $90 total per night
$90 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.
Pool
Pet friendly
Embassy Suites Palmdale

Embassy Suites Palmdale

3.5 out of 5
39375 5th St W Palmdale CA
Free Cancellation
Reserve now, pay when you stay
1.01 mi from Palmdale Regional Medical Center
$127 nightly
The price is $143 total per night
$143 total
Dec 20 - Dec 21
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy the free cooked-to-order breakfast each morning.
Pool
Breakfast included
Triplodge of Santa Clarita

Triplodge of Santa Clarita

3 out of 5
17843 Sierra Hwy Canyon Country CA
Free Cancellation
Reserve now, pay when you stay
20.29 mi from Palmdale Regional Medical Center
$103 nightly
The price is $114 total per night
$114 total
Dec 24 - Dec 25
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Business travelers can take advantage of the business center. Guests will appreciate freebies like on-the-go breakfast and free self parking.
Pool
Hot Tub
Travelodge by Wyndham Sylmar CA

Travelodge by Wyndham Sylmar CA

2 out of 5
14955 Roxford St Sylmar CA
Free Cancellation
Reserve now, pay when you stay
25.31 mi from Palmdale Regional Medical Center
$93 nightly
The price is $108 total per night
$108 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Free WiFi in public areas is available at this motel. Take advantage of the free self parking.
Pool
Parking included
Santa Clarita Motel

Santa Clarita Motel

2 out of 5
24971 Railroad Ave. Newhall CA
Free Cancellation
25.83 mi from Palmdale Regional Medical Center
$80 nightly
The price is $88 total per night
$88 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the express check-out. The front desk is staffed around-the-clock and laundry facilities are on offer.
Parking included
Free WiFi
Hotel Lexen - Newhall

Hotel Lexen - Newhall

2.5 out of 5
24219 Railroad Avenue Newhall CA
Free Cancellation
Reserve now, pay when you stay
25.83 mi from Palmdale Regional Medical Center
$120 nightly
The price is $134 total per night
$134 total
Dec 16 - Dec 17
Total with taxes and fees
This hotel features a gym and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, express check-out, and luggage storage are also on offer.
Parking included
Free WiFi
Hyatt Regency Valencia

Hyatt Regency Valencia

3.5 out of 5
24500 Town Center Drive Valencia CA
Free Cancellation
Reserve now, pay when you stay
26.3 mi from Palmdale Regional Medical Center
$135 nightly
The price is $152 total per night
$152 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour gym and conveniences like a 24-hour front desk and laundry facilities.
Pool
Hot Tub
Vagabond Inn Sylmar

Vagabond Inn Sylmar

3 out of 5
12775 Encinitas Avenue Sylmar CA
Free Cancellation
27.02 mi from Palmdale Regional Medical Center
$90 nightly
The price is $105 total per night
$105 total
Dec 16 - Dec 17
Total with taxes and fees
This inn doesn't skimp on freebies - guests receive free WiFi and free self parking. A terrace is provided and the front desk is staffed around-the-clock.
Pet friendly
Parking included
Best Western Valencia/Six Flags Inn & Suites

Best Western Valencia/Six Flags Inn & Suites

2.5 out of 5
27513 Wayne Mills Place Valencia CA
Free Cancellation
Reserve now, pay when you stay
27.11 mi from Palmdale Regional Medical Center
$123 nightly
The price is $138 total per night
$138 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included
Hilton Garden Inn Valencia Six Flags

Hilton Garden Inn Valencia Six Flags

3 out of 5
27710 The Old Rd Valencia CA
Free Cancellation
Reserve now, pay when you stay
27.25 mi from Palmdale Regional Medical Center
$99 nightly
The price is $111 total per night
$111 total
Dec 21 - Dec 22
Total with taxes and fees
This hotel features an outdoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. Enjoy the gym and perks like free self parking.
Pool
Hot Tub
Ramada by Wyndham Burbank Airport

Ramada by Wyndham Burbank Airport

2 out of 5
2900 N San Fernando Blvd Burbank CA
Free Cancellation
Reserve now, pay when you stay
28.57 mi from Palmdale Regional Medical Center
$129 nightly
The price is $143 total per night
$143 total
Dec 11 - Dec 12
Total with taxes and fees
A restaurant and an outdoor pool are featured at this hotel. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free self parking, a coffee shop, and a grocery/convenience store are also offered.
Pool
Parking included
Hotel Burbank

Hotel Burbank

3 out of 5
150 E Angeleno Ave Burbank CA
Free Cancellation
Reserve now, pay when you stay
29.3 mi from Palmdale Regional Medical Center
$137 nightly
The price is $153 total per night
$153 total
Dec 17 - Dec 18
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Enjoy the sauna and perks like free WiFi and a free airport shuttle. A bar/lounge, a 24-hour front desk, and a coffee shop are also provided.
Pool
Free airport shuttle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Palmdale Regional Medical Center hotels essential information

Accommodation
1,260 hotels
Lowest Price
$88
Highest Price
$153
Popular hotels
DoubleTree by Hilton Palmdale, CA, Embassy Suites Palmdale, Triplodge of Santa Clarita, Hotel Burbank, Ramada by Wyndham Burbank Airport, Travelodge by Wyndham Sylmar CA, Hotel Lexen - Newhall, Santa Clarita Motel, Hyatt Regency Valencia, Best Western Valencia/Six Flags Inn & Suites, Hilton Garden Inn Valencia Six Flags, Vagabond Inn Sylmar

Recent Palmdale Regional Medical Center hotel reviews by fellow wanderers

Ramada by Wyndham Burbank Airport

Ramada by Wyndham Burbank Airport

5 out of 5
Posted 1 day ago
Travelocity Verified Review
"It was nice for you. We will stay here again."
A verified traveler from San Diego stayed at Ramada by Wyndham Burbank Airport
Ramada by Wyndham Burbank Airport

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