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Top hotels close to Palmdale Regional Medical Center

Holiday Inn Palmdale-Lancaster by IHG
38630 5th St W Palmdale CA
Free Cancellation
0.47 mi from Palmdale Regional Medical Center
$93 nightly
The price is $104 total per night
$104 total
Dec 28 - Dec 29
Total with taxes and fees
This hotel features an outdoor pool, a hot tub, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.
Pool
Hot Tub

DoubleTree by Hilton Palmdale, CA
West Palmdale Boulevard, 300 Palmdale CA
Free Cancellation
Reserve now, pay when you stay
0.65 mi from Palmdale Regional Medical Center
$84 nightly
The price is $94 total per night
$94 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the gym and perks like free self parking.
Pool
Pet friendly

Wyndham Garden Lancaster CA
2038 W Avenue I Lancaster CA
Free Cancellation
Reserve now, pay when you stay
8.5 mi from Palmdale Regional Medical Center
$103 nightly
The price is $114 total per night
$114 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free buffet breakfast each morning.
Pool
Hot Tub

Triplodge of Santa Clarita
17843 Sierra Hwy Canyon Country CA
Free Cancellation
Reserve now, pay when you stay
20.29 mi from Palmdale Regional Medical Center
$103 nightly
The price is $114 total per night
$114 total
Jan 12 - Jan 13, 2026
Total with taxes and fees
This hotel features an outdoor pool and a hot tub. Business travelers can take advantage of the business center. Guests will appreciate freebies like on-the-go breakfast and free self parking.
Pool
Hot Tub

Travelodge by Wyndham Sylmar CA
14955 Roxford St Sylmar CA
Free Cancellation
Reserve now, pay when you stay
25.31 mi from Palmdale Regional Medical Center
$96 nightly
The price is $112 total per night
$112 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Free WiFi in public areas is available at this motel. Take advantage of the free self parking.
Pool
Parking included

Santa Clarita Motel
24971 Railroad Ave. Newhall CA
Free Cancellation
25.83 mi from Palmdale Regional Medical Center
$80 nightly
The price is $88 total per night
$88 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Business travelers can take advantage of the express check-out. The front desk is staffed around-the-clock and laundry facilities are on offer.
Parking included
Free WiFi

Hotel Lexen - Newhall
24219 Railroad Avenue Newhall CA
Free Cancellation
Reserve now, pay when you stay
25.83 mi from Palmdale Regional Medical Center
$120 nightly
The price is $134 total per night
$134 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features a gym and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, express check-out, and luggage storage are also on offer.
Parking included
Free WiFi

Hyatt Regency Valencia
24500 Town Center Drive Valencia CA
Free Cancellation
Reserve now, pay when you stay
26.3 mi from Palmdale Regional Medical Center
$152 nightly
The price is $171 total per night
$171 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour gym and conveniences like a 24-hour front desk and laundry facilities.
Pool
Hot Tub

Best Western Valencia/Six Flags Inn & Suites
27513 Wayne Mills Place Valencia CA
Free Cancellation
Reserve now, pay when you stay
27.11 mi from Palmdale Regional Medical Center
$128 nightly
The price is $143 total per night
$143 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
This hotel features an outdoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
Pool
Breakfast included

Hilton Garden Inn Valencia Six Flags
27710 The Old Rd Valencia CA
Free Cancellation
Reserve now, pay when you stay
27.25 mi from Palmdale Regional Medical Center
$104 nightly
The price is $117 total per night
$117 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas and free internet in public areas. There's a gym on site, and a 24-hour front desk and a garden are also provided.
Pool
Hot Tub

Ramada by Wyndham Burbank Airport
2900 N San Fernando Blvd Burbank CA
Free Cancellation
Reserve now, pay when you stay
28.57 mi from Palmdale Regional Medical Center
$129 nightly
The price is $143 total per night
$143 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
A restaurant and an outdoor pool are featured at this hotel. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free self parking, a coffee shop, and a grocery/convenience store are also offered.
Pool
Parking included

Hotel Burbank
150 E Angeleno Ave Burbank CA
Free Cancellation
Reserve now, pay when you stay
29.3 mi from Palmdale Regional Medical Center
$145 nightly
The price is $162 total per night
$162 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Enjoy the sauna and perks like free WiFi and a free airport shuttle. A bar/lounge, a 24-hour front desk, and a coffee shop are also provided.
Pool
Free airport shuttle
Don't see what you're looking for?
See all available properties in Palmdale Regional Medical Center
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Palmdale Regional Medical Center hotels essential information
Accommodation | 1,282 hotels |
|---|---|
Lowest Price | $88 |
Highest Price | $171 |
Popular hotels | DoubleTree by Hilton Palmdale, CA, Holiday Inn Palmdale-Lancaster by IHG, Wyndham Garden Lancaster CA, Triplodge of Santa Clarita, Hotel Burbank, Ramada by Wyndham Burbank Airport, Travelodge by Wyndham Sylmar CA, Hotel Lexen - Newhall, Santa Clarita Motel, Hyatt Regency Valencia, Hilton Garden Inn Valencia Six Flags, Best Western Valencia/Six Flags Inn & Suites |
Recent Palmdale Regional Medical Center hotel reviews by fellow wanderers

Hotel Burbank
5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Always stay here when in Burbank. It is just steps away from downtown and many great restaurants. I love the Christmas decorations they put up each year."
A verified traveler stayed at Hotel Burbank
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