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Top hotels in Historic Southwest

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$102 nightly
The price is $117 total per night from Sep 6 to Sep 7
$117 total
Sep 6 - Sep 7
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached ..."

Reviewed on Aug 23, 2026

Opens in a new windowHotel Indigo Rochester – Mayo Clinic Area by IHG
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $124 total per night from Sep 4 to Sep 5
$124 total
Sep 4 - Sep 5
Total with taxes and fees
This hotel features an indoor pool, a 24-hour gym, and a restaurant. There's fun for all ages with a children's pool and an arcade/game room, and families will ...
"Dirty at the pool. Ants on the floor. Room was not really clean."

Reviewed on Sep 1, 2026

Opens in a new windowCenterstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"The convenience to Mayo facility is the best."

Reviewed on Sep 1, 2026

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Opens in a new windowKahler Grand Hotel
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

3 out of 5
225 S Broadway Rochester MN
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $131 total per night from Sep 11 to Sep 12
$131 total
Sep 11 - Sep 12
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Enjoy the 24-hour gym and perks like free WiFi. There's a hot tub on site, and laundry facilities ...
Opens in a new windowHilton Garden Inn Rochester Downtown, MN
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $160 total per night from Sep 9 to Sep 10
$160 total
Sep 9 - Sep 10
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $90 total per night from Sep 6 to Sep 7
$90 total
Sep 6 - Sep 7
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public ...
Opens in a new windowAmericInn by Wyndham Rochester Near Mayo Clinic
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
Fully refundable
$117 nightly
The price is $134 total per night from Sep 11 to Sep 12
$134 total
Sep 11 - Sep 12
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Opens in a new windowEVEN Hotel Rochester - Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $114 total per night from Sep 20 to Sep 21
$114 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Bring the family and enjoy the children's pool, waterslide, and arcade/game room. Enjoy the ...
Opens in a new windowBest Western Rochester Hotel Mayo Clinic Area/St. Mary's
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $82 total per night from Sep 3 to Sep 4
$82 total
Sep 3 - Sep 4
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
Opens in a new windowMed City Inn & Suites - Mayo Clinic Area
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See all available properties in Historic Southwest
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Historic Southwest Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Historic Southwest area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Historic Southwest to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Historic Southwest are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Historic Southwest hotel reviews by fellow wanderers

Kahler Grand Hotel

Kahler Grand Hotel

5 out of 5
Posted 13 hours ago
Travelocity Verified Review
"The convenience to Mayo facility is the best."
A verified traveler stayed at Kahler Grand Hotel
Kahler Grand Hotel