Explore 120 Luxury Hotels in Florida Keys
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Best Luxury Hotels in Florida Keys
H2O Suites - Adults Only
1212 Simonton Street Key West FL
$559 nightly
The price is $629 total per night from Jan 4 to Jan 5
$629 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (582 reviews)
Immaculate, beautifully decorated, warm and friendly staff. The welcome congratulation and champagne waiting for our arrival.
Reviewed on Dec 21, 2025
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82 Islamorada FL
Fully refundableReserve now, pay when you stay
$328 nightly
The price is $370 total per night from Jan 4 to Jan 5
$370 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
9.2/10 Wonderful! (1,276 reviews)
It was over the top amazing
Reviewed on Dec 27, 2025
The Marker Key West Harbor Resort
200 William Street Key West FL
Fully refundableReserve now, pay when you stay
$438 nightly
The price is $492 total per night from Jan 14 to Jan 15
$492 total
Jan 14 - Jan 15, 2026
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9/10 Wonderful! (1,001 reviews)
Staff was great loved the restaurant bar area and pizza
Reviewed on Dec 22, 2025
Parmer's Resort
565 Barry Avenue Summerland Key FL
Fully refundableReserve now, pay when you stay
$243 nightly
The price is $273 total per night from Jan 5 to Jan 6
$273 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
The private beach and marina are among the highlights at this motel. Spend a day at the beach kayaking, or relax with sun loungers and beach umbrellas. Enjoy ...
9/10 Wonderful! (1,002 reviews)
Gorgeous view, convenient location, friendly staff!
Reviewed on Dec 24, 2025
Oceans Edge Key West Resort, Hotel & Marina
5950 Peninsular Avenue Key West FL
Fully refundableReserve now, pay when you stay
$292 nightly
The price is $328 total per night from Jan 26 to Jan 27
$328 total
Jan 26 - Jan 27, 2026
Total with taxes and fees
A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public areas. ...
8.8/10 Excellent! (1,761 reviews)
So many activities and amazing staff and service. The shuttle was very convenient. I would stay here again! Perfect for families. I felt safe. Very laid back environment.
Reviewed on Dec 26, 2025
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
Fully refundable
$360 nightly
The price is $405 total per night from Jan 13 to Jan 14
$405 total
Jan 13 - Jan 14, 2026
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling ...
8.6/10 Excellent! (2,938 reviews)
Amazing 👌
Reviewed on Dec 22, 2025
Kingsail Resort
7050 Overseas Highway Marathon FL
$136 nightly
The price is $153 total per night from Jan 11 to Jan 12
$153 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
A marina and an outdoor pool are featured at this smoke-free motel. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, ...
8.4/10 Very Good! (1,033 reviews)
The room was very clean & comfy. All the staff were very friendly & helpful. The price was grt & the location is close to everything. Stayed a wk & having a laungry room on site was nice. I recommend this place highly. Will def be staying there in the future.
Reviewed on Dec 26, 2025
Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street Key West FL
Fully refundableReserve now, pay when you stay
$463 nightly
The price is $520 total per night from Jan 13 to Jan 14
$520 total
Jan 13 - Jan 14, 2026
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
8.2/10 Very Good! (482 reviews)
The view was almost spectacular except the hotel has permanently parked some kind of van right outside between the ocean view patios and the beach. It was there all week during our stay. We were on the second floor so it was really detracting from the view we paid for.
Reviewed on Dec 21, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Florida Keys
Marlin Bay Resort & Marina
3800 Gulfview Ave Marathon FL
5 star hotels in Florida Keys
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82 Islamorada FL
$328 nightly
The price is $370 total per night from Jan 4 to Jan 5
$370 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
9.2/10 Wonderful! (1,276 reviews)
Florida Keys Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florida Keys luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Florida Keys to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Florida Keys will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florida Keys, and plan your next opulent escape.
Florida Keys hotels essential information
Accommodation | 8,409 hotels |
|---|---|
Lowest Price | $153 |
Highest Price | $740 |
Popular hotels | Oceans Edge Key West Resort, Hotel & Marina, The Marker Key West Harbor Resort, Cheeca Lodge & Spa, Casa Marina Key West, Curio Collection by Hilton, Kingsail Resort, Southernmost Beach Resort and Guesthouses, Parmer's Resort, H2O Suites - Adults Only |
Popular Luxury Stays in Florida Keys
Recent Florida Keys Hotel Reviews By Fellow Wanderers
Cheeca Lodge & Spa
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"It was over the top amazing"
A verified traveler stayed at Cheeca Lodge & Spa
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