Explore 120 Luxury Hotels in Florida Keys
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Best Luxury Hotels in Florida Keys
H2O Suites - Adults Only
1212 Simonton Street Key West FL
$357 nightly
The price is $402 total per night from Oct 13 to Oct 14
$402 total
Oct 13 - Oct 14
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (663 reviews)
"Great place nice people I love it thank you"
Reviewed on Oct 4, 2026
The Marker Key West Harbor Resort
200 William Street Key West FL
Fully refundable
$282 nightly
The price is $317 total per night from Oct 26 to Oct 27
$317 total
Oct 26 - Oct 27
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9.2/10 Wonderful! (1,022 reviews)
"Bathroom floor had hair all over the place. They decided to close the main pool and begin repairs which was loud and dusty. Basically we could not hang out at the pool. Staff was unapologetic. On the bright side the bartender was very nice and made great cocktails."
Reviewed on Oct 3, 2026
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82 Islamorada FL
Fully refundableReserve now, pay when you stay
$218 nightly
The price is $245 total per night from Oct 13 to Oct 14
$245 total
Oct 13 - Oct 14
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
9.2/10 Wonderful! (1,471 reviews)
"I love the Florida Keys, especially Islamorada. The staff was super friendly and the service was excellent. The activities were also great. However, the hotel and rooms need some maintenance and upgrades. The elevator was not working, the bathroom could have been cleaner, and you can definitely see ..."
Reviewed on Oct 5, 2026
Hilton Key West Resort & Marina
5950 Peninsular Avenue Key West FL
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $201 total per night from Oct 12 to Oct 13
$201 total
Oct 12 - Oct 13
Total with taxes and fees
A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas ...
9/10 Wonderful! (1,802 reviews)
"This was our second time to stay here and this place never disappoints. Staff is wonderful too"
Reviewed on Oct 3, 2026
Parmer's Resort
565 Barry Avenue Summerland Key FL
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $175 total per night from Nov 1 to Nov 2
$175 total
Nov 1 - Nov 2
Total with taxes and fees
The private beach and marina are among the highlights at this motel. Spend a day at the beach kayaking, or relax with sun loungers and beach umbrellas. Enjoy ...
9/10 Wonderful! (1,001 reviews)
"Just a fantastic property, wonderful staff, great amenities, so many waterfront places to chill. Immaculate grounds with a laid back vibe, loved it!!"
Reviewed on Oct 4, 2026
Kingsail Resort
7050 Overseas Highway Marathon FL
$81 nightly
The price is $91 total per night from Oct 12 to Oct 13
$91 total
Oct 12 - Oct 13
Total with taxes and fees
A marina and an outdoor pool are featured at this smoke-free motel. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, ...
8.6/10 Excellent! (1,128 reviews)
"El hotel nos encanto, nos registramos antes de la hora acordada, el personal es maravilloso, la habitación es una mini casa con todo los accesorios necesarios para su comodidad, las camas muy cómodas y limpias, el hospedaje incluye cayak sin costo adicional , ofrecen café free en la piscina, y un ..."
Reviewed on Oct 4, 2026
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $286 total per night from Oct 13 to Oct 14
$286 total
Oct 13 - Oct 14
Total with taxes and fees
A full-service spa, 3 outdoor pools, and a restaurant are all featured at this hotel. Traveling on business? Take advantage of the 2 conference rooms, free WiFi ...
8.6/10 Excellent! (3,618 reviews)
"The resort itself was nice and most of the staff was super nice! But we paid way too much money for us not to be aware that the big pool was closed for the week and on top of it they ran a power washer for 3 days which sounded like it was inside of or room! It ran from 9-5 only turning off for about ..."
Reviewed on Oct 4, 2026
Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street Key West FL
Fully refundableReserve now, pay when you stay
$306 nightly
The price is $344 total per night from Oct 12 to Oct 13
$344 total
Oct 12 - Oct 13
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
8.4/10 Very Good! (953 reviews)
"Clear room, great views"
Reviewed on Oct 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Florida Keys
Marlin Bay Resort & Marina
3800 Gulfview Ave Marathon FL
10/10 Exceptional! (3 reviews)
5 star hotels in Florida Keys
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82 Islamorada FL
$218 nightly
The price is $245 total per night from Oct 13 to Oct 14
$245 total
Oct 13 - Oct 14
Total with taxes and fees
9.2/10 Wonderful! (1,471 reviews)
Florida Keys Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florida Keys luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Florida Keys to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Florida Keys will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florida Keys, and plan your next opulent escape.
Florida Keys hotels essential information
Accommodation | 8,253 hotels |
|---|---|
Lowest Price | $91 |
Highest Price | $680 |
Popular hotels | Hilton Key West Resort & Marina, The Marker Key West Harbor Resort, Cheeca Lodge & Spa, Casa Marina Key West, Curio Collection by Hilton, Kingsail Resort, Southernmost Beach Resort and Guesthouses, Parmer's Resort, H2O Suites - Adults Only |
Popular Luxury Stays in Florida Keys
Recent Florida Keys Hotel Reviews By Fellow Wanderers
Waterside Suites & Marina
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"Clean and affordable to say the least Located closely to many restaurants and stores for essentials"
A verified traveler stayed at Waterside Suites & Marina
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