Explore 120 Luxury Hotels in Florida Keys
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Best Luxury Hotels in Florida Keys
H2O Suites - Adults Only
1212 Simonton Street Key West FL
$367 nightly
The price is $413 total per night from Jun 29 to Jun 30
$413 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Business travelers can take advantage of the laundry service. There's a gym on site, and ...
9.8/10 Exceptional! (619 reviews)
"Awesome place to stay!"
Reviewed on Jun 23, 2026
The Marker Key West Harbor Resort
200 William Street Key West FL
Fully refundableReserve now, pay when you stay
$238 nightly
The price is $267 total per night from Jul 6 to Jul 7
$267 total
Jul 6 - Jul 7
Total with taxes and fees
This smoke-free hotel features 3 outdoor pools, a gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in ...
9.2/10 Wonderful! (1,006 reviews)
"Great location. Room overlooking the harbor was great, as spent mornings and evenings on balcony watching all the activities."
Reviewed on Jun 22, 2026
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82 Islamorada FL
Fully refundableReserve now, pay when you stay
$285 nightly
The price is $321 total per night from Jul 19 to Jul 20
$321 total
Jul 19 - Jul 20
Total with taxes and fees
This luxury resort features a private beach, a golf course, and a full-service spa. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. ...
9.2/10 Wonderful! (1,329 reviews)
"The decor was updated a bit but then dated in other areas. The balcony cushions had stains and the carpet needed to be replaced."
Reviewed on Jun 23, 2026
Oceans Edge Key West Resort, Hotel & Marina
5950 Peninsular Avenue Key West FL
Fully refundableReserve now, pay when you stay
$212 nightly
The price is $238 total per night from Jul 19 to Jul 20
$238 total
Jul 19 - Jul 20
Total with taxes and fees
A marina, 6 outdoor pools, and a 24-hour gym are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public areas. ...
9/10 Wonderful! (1,861 reviews)
"Very nice! Very clean. Rooms are big! Shuttle to and from Duval St every hour was super convenient! Great stay!"
Reviewed on Jun 24, 2026
Parmer's Resort
565 Barry Avenue Summerland Key FL
Fully refundableReserve now, pay when you stay
$198 nightly
The price is $223 total per night from Jun 25 to Jun 26
$223 total
Jun 25 - Jun 26
Total with taxes and fees
The private beach and marina are among the highlights at this motel. Spend a day at the beach kayaking, or relax with sun loungers and beach umbrellas. Enjoy ...
9/10 Wonderful! (1,002 reviews)
"The staff here are amazing they are so nice and helpful. The breakfast in the morning was much more than we had expected and cookies and lemonade in the afternoon was a special treat again not expected but a nice touch. Our room was somewhat dated but we’re not there to spend time in the room. My ..."
Reviewed on Jun 20, 2026
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $286 total per night from Jul 6 to Jul 7
$286 total
Jul 6 - Jul 7
Total with taxes and fees
This hotel features a full-service spa, 3 outdoor pools, and a restaurant. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. Traveling ...
8.8/10 Excellent! (3,402 reviews)
"The room was very clean. The staff was helpful."
Reviewed on Jun 24, 2026
Kingsail Resort
7050 Overseas Highway Marathon FL
$110 nightly
The price is $123 total per night from Jul 9 to Jul 10
$123 total
Jul 9 - Jul 10
Total with taxes and fees
A marina and an outdoor pool are featured at this smoke-free motel. Guests will appreciate free perks like free self parking and WiFi in public areas. A terrace, ...
8.6/10 Excellent! (1,086 reviews)
"Not fancy but clean and felt safe. Staff was very helpful and they had some nice amenities (boat slips, pool, etc.)"
Reviewed on Jun 23, 2026
Casa Marina Key West, Curio Collection by Hilton
1500 Reynolds Street Key West FL
Fully refundableReserve now, pay when you stay
$267 nightly
The price is $301 total per night from Jul 5 to Jul 6
$301 total
Jul 5 - Jul 6
Total with taxes and fees
A private beach, a full-service spa, and 2 outdoor pools are all featured at this smoke-free resort. Relax with sun loungers and beach umbrellas, and cool off ...
8.4/10 Very Good! (720 reviews)
"The resort itself was beautiful, and our room was spacious and comfortable. The property has a lot to offer, and we were looking forward to a relaxing vacation. Unfortunately, the first three nights of our stay were anything but relaxing due to a business event being held at the resort. Our room ..."
Reviewed on Jun 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Florida Keys
Marlin Bay Resort & Marina
3800 Gulfview Ave Marathon FL
10/10 Exceptional! (3 reviews)
5 star hotels in Florida Keys
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82 Islamorada FL
$285 nightly
The price is $321 total per night from Jul 19 to Jul 20
$321 total
Jul 19 - Jul 20
Total with taxes and fees
9.2/10 Wonderful! (1,329 reviews)
Florida Keys Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Florida Keys luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Florida Keys to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Florida Keys will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Florida Keys, and plan your next opulent escape.
Florida Keys hotels essential information
Accommodation | 8,301 hotels |
|---|---|
Lowest Price | $123 |
Highest Price | $848 |
Popular hotels | Oceans Edge Key West Resort, Hotel & Marina, The Marker Key West Harbor Resort, Cheeca Lodge & Spa, Casa Marina Key West, Curio Collection by Hilton, Kingsail Resort, Southernmost Beach Resort and Guesthouses, Parmer's Resort, H2O Suites - Adults Only |
Popular Luxury Stays in Florida Keys
Recent Florida Keys Hotel Reviews By Fellow Wanderers
Playa Largo Resort & Spa, Autograph Collection
5 out of 5
Posted 10 hours ago
Travelocity Verified Review
"We loved our stay! The hotel was in excellent condition and exceptionally clean. The restaurants were beautiful, well-maintained, and offered delicious food. We enjoyed both dinner and breakfast at La Marea Restaurant, and everything was absolutely delicious. All of the staff were friendly, welcoming, and helpful throughout our stay. We would definitely recommend this hotel and look forward to returning! ⭐⭐⭐⭐⭐"
A verified traveler stayed at Playa Largo Resort & Spa, Autograph Collection
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