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Top Cairo hotels deals

Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 out of 5
13201 Kessler Road Cairo IL
Free Cancellation
$71 nightly
The price is $79 total per night
$79 total
Oct 2 - Oct 3
Total with taxes and fees
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free full breakfast each morning. A picnic area is provided and the front desk is staffed around-the-clock.
Breakfast included
Pet friendly
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Free Cancellation
Reserve now, pay when you stay
$60 nightly
The price is $66 total per night
$66 total
Sep 27 - Sep 28
Total with taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer station and multilingual staff can provide around-the-clock assistance.
Breakfast included
Pet friendly
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Free Cancellation
$66 nightly
The price is $74 total per night
$74 total
Sep 26 - Sep 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 24-hour business center and free internet in public areas. Enjoy the seasonal outdoor pool and conveniences like a 24-hour front desk and laundry facilities.
Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake

Miller City IL
$205 nightly
The price is $217 total per night
$217 total
Sep 26 - Sep 27
Total with taxes and fees
This cabin features barbecue grills.
Kitchen
Pet friendly
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

Olive Branch IL
$133 nightly
The price is $140 total per night
$140 total
Sep 25 - Sep 26
Total with taxes and fees
Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning.
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

Dongola IL
$239 nightly
The price is $253 total per night
$253 total
Sep 25 - Sep 26
Total with taxes and fees
This cabin features a garden, laundry facilities, and barbecue grills.
Kitchen
Washer
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
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Frequently asked questions

How much are vacation packages to Cairo?
You'll be pleasantly surprised — you can find yourself in Cairo for just . Allow Travelocity to save you time and money with our awesome vacation package deals. With hotels, flights and tours all in one place, what are you waiting for?
Where can I get the best vacation package deals for Cairo?
With around 400 partner airlines and 1,000,000 hotels across the world, you can't beat Travelocity. Scroll through our impressive range and create the perfect package deal to Cairo. Doesn't it feel amazing when organizing a trip is that easy?
Why should I book my Cairo vacation package via Travelocity?
Nothing tops the satisfaction of knowing you've bagged the best price around — that's our Price Match Guarantee. Add to that our fantastic range of destinations and 24/7 team of customer service professionals and you've got the formula for a stress-free vacation.
Can I save on my Cairo car rental if I book it with hotels and flights?
With a Cairo vacation package, you can bundle your car, flight and hotel bookings and save some serious money. When you're ready to explore the best of this awesome city, why not make a beeline for Anheuser-Busch Brewery? This popular attraction is 120 mi from Cairo. With your own rental car, you'll be there in the blink of an eye.
Which airport is best for Cairo?
Williamson County Regional Airport (MWA) is 50 mi from downtown and is the beginning point for many memorable experiences. Alternatively, Cape Girardeau Municipal Airport (CGI) is 25 mi away from central Cairo and Barkley Regional Airport (PAH) is 25 mi away from central Cairo.
What is there to do in Cairo?
Click away at the excellent photo opportunities at Fort Defiance State Park, one of the most popular attractions in Cairo. There's a lot more to discover around this exciting city, so make sure you have enough time to visit some of its off-the-beaten-path gems.
Where should I stay when visiting Cairo?
The Quality Inn Cairo I-57 is popular with many visitors. Book soon to avoid missing out.

Photos of local treasures

Browse Cairo vacation photos for more inspiration

A steel bridge with a sunset in the background.
A steel truss bridge over a river with a cloudy sky.
A river with a dam, surrounded by greenery and a clear sky.
A tree-lined landscape with a river and fields.

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