Book a hotel near Fort Defiance State Park, Cairo
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Top hotels close to Fort Defiance State Park

Quality Inn Cairo I-57
13201 Kessler Road, Cairo, IL
Free Cancellation
Reserve now, pay when you stay
4.85 mi from Fort Defiance State Park
The price is $74 per night
$74
includes taxes & fees
$67 per night
Jun 7 - Jun 8
This hotel features free WiFi in public areas, free newspapers, and free self parking. Enjoy the free full breakfast each morning. A picnic area is provided and the front desk is staffed around-the-clock.
Breakfast included
Pet friendly

Eagle Inn Charleston
2811 East Marshall Street, Charleston, MO
Free Cancellation
Reserve now, pay when you stay
10.04 mi from Fort Defiance State Park
The price is $71 per night
$71
includes taxes & fees
$64 per night
May 12 - May 13
A gym is featured at this motel, along with free self parking. WiFi in public areas is free. Staff at the 24-hour front desk can provide around-the-clock assistance.
Pet friendly
Parking included

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Free Cancellation
Reserve now, pay when you stay
10.88 mi from Fort Defiance State Park
The price is $71 per night
$71
includes taxes & fees
$64 per night
May 11 - May 12
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. There's a computer station and multilingual staff can provide around-the-clock assistance.
Breakfast included
Pet friendly

Quality Inn Charleston - Sikeston
102 Drake St, I-57 Exit 10, Charleston, MO
Free Cancellation
Reserve now, pay when you stay
12.55 mi from Fort Defiance State Park
The price is $73 per night
$73
includes taxes & fees
$66 per night
Jun 1 - Jun 2
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business center and free internet in public areas. A safe deposit box is provided and the front desk is staffed around-the-clock.
Breakfast included
Pet friendly

Peaceful secluded cabin located near Horseshoe Lake
13.12 mi from Fort Defiance State Park
The price is $193 per night
$193
includes taxes & fees
$193 per night
May 10 - May 11
This cabin features barbecue grills.
Kitchen
Pet friendly

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
16.21 mi from Fort Defiance State Park
This vacation home features a garden, laundry facilities, and barbecue grills.
Breakfast included
Kitchen

Cozy cabins on beautiful Horseshoe Lake
17.13 mi from Fort Defiance State Park
The price is $135 per night
$135
includes taxes & fees
$135 per night
May 10 - May 11
Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning.
Air conditioning
Lake view

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
19.46 mi from Fort Defiance State Park
The price is $247 per night
$247
includes taxes & fees
$229 per night
May 11 - May 12
This vacation home featured laundry facilities and barbecue grills.
Washer
Dryer

Regency Inn
128 CHEEKWOOD LN, Ullin, IL
19.79 mi from Fort Defiance State Park
The price is $106 per night
$106
includes taxes & fees
$99 per night
May 21 - May 22
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are on offer.
Pet friendly
Parking included

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
22.32 mi from Fort Defiance State Park
The price is $96 per night
$96
includes taxes & fees
$84 per night
Jun 1 - Jun 2
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.
Pool
Breakfast included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
22.34 mi from Fort Defiance State Park
The price is $92 per night
$92
includes taxes & fees
$81 per night
Jun 1 - Jun 2
This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.
Breakfast included
Pet friendly

Pear Tree Inn Sikeston
2602 E Malone Avenue, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
22.61 mi from Fort Defiance State Park
The price is $98 per night
$98
includes taxes & fees
$85 per night
May 18 - May 19
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free daily breakfast.
Pool
Hot Tub
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See all available properties in Fort Defiance State Park
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Fort Defiance State Park hotels essential information
Accommodation | 178 hotels |
---|---|
Lowest Price | $71 |
Highest Price | $247 |
Popular hotels | Quality Inn Cairo I-57, Super 8 by Wyndham Charleston/Sikeston East MO, Eagle Inn Charleston, Quality Inn Charleston - Sikeston, Peaceful secluded cabin located near Horseshoe Lake , Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286, Cozy cabins on beautiful Horseshoe Lake, Pear Tree Inn Sikeston, Welcome campers, hikers, fishermen, girls' weekend wine getaways!!, Regency Inn, Best Western Plus Sikeston, Days Inn and Suites by Wyndham Sikeston |
Recent Fort Defiance State Park hotel reviews by fellow wanderers

Pear Tree Inn Sikeston
5 out of 5
Posted 3 days ago
Travelocity Verified Review
"Stayed one night while traveling. Hotel was friendly, clean, and comfortable. Staff was knowledgeable in directing us to local restaurants, and they had an interesting snack time where they had free popcorn and other snack items. Breakfast had several of the usual items available, but the sausage patties were good. Would stay here again."
A verified traveler stayed at Pear Tree Inn Sikeston
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