Book Hotels in Cairo, MO
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Top Cairo hotels

Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness
Cairo MO
This vacation home featured laundry facilities and barbecue grills.
"Wonderful location that is very private and peaceful. The house is decorated very well and they have complimentary breakfast. Perfect for a weekend getaway."
Reviewed on Apr 27, 2026

Spacious 7000 square foot 12-bedroom 10-Bath lodge in Picturesque Macon Missouri
Macon MO
This lodge featured laundry facilities and barbecue grills.
Family reunion
"The rooms were very clean and comfortable. It was very hot and humid outside, but the AC and ceiling fans kept up well. The host answered questions quickly. We had rain (and lots of it) every day but our last, but had a good time anyway; making use of the game room, large dining areas for other games, ..."
Reviewed on Jul 28, 2025

Comfort Inn & Suites Macon
1821 N. Missouri St Macon MO
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Yes"
Reviewed on May 11, 2026

Comfort Inn & Suites Moberly
1801 W Outer Rd Moberly MO
Fully refundable
$120 nightly
The price is $135 total per night from Jun 14 to Jun 15
$135 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. A business ...
"Fantastic biscuits and gravy. Friendly staff. Hot tub was great but pool was freezing cold."
Reviewed on May 12, 2026

Super 8 by Wyndham Moberly MO
300 E Highway 24 Moberly MO
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $91 total per night from May 31 to Jun 1
$91 total
May 31 - Jun 1
Total with taxes and fees
Free self parking is available and the motel's front desk is staffed around-the-clock. Guests will appreciate free perks like on-the-go breakfast and WiFi in ...
"Our room had a huge chair which shoved the bed over and therefor the one side had no nightstand. In this day and age each side needs a place to put things, charge the phone, have a light etc. There were no bath towels, cups or soap of any kind, even at the sink."
Reviewed on May 17, 2026

Super 8 by Wyndham Macon
203 E Briggs Dr Macon MO
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $82 total per night from May 26 to May 27
$82 total
May 26 - May 27
Total with taxes and fees
This motel features free WiFi in public areas, barbecue grills, and free self parking. Enjoy the free on-the-go breakfast each morning. Staff at the 24-hour ...
"Waited at the desk for over 10 mins before being acknowledged. The smell of cat urine in the air. Hole in bathroom by the shower. The sheets looked cleaned but definitely not the other bed covers. Went and purchased Lysol and wet wipes and cleaned the room. Tried finding something different nothing ..."
Reviewed on May 3, 2026

Travelier Motel
201 E Briggs Dr Macon MO
This hotel features WiFi in public areas, laundry facilities, and free parking. Guests will appreciate freebies like continental breakfast and free self parking. ...
"The staff are very welcoming but the advertising I saw was not what we actually got. Disappointed."
Reviewed on May 11, 2026

Americas Best Value Inn & Suites Macon at Sunset Dr
28933 Sunset Drive Macon MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $73 total per night from May 21 to May 22
$73 total
May 21 - May 22
Total with taxes and fees
A restaurant and a bar/lounge are featured at this motel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self ...
"The room was clean and property easy to get to other locations. Front desk was nice. I clicked on pet but didn’t transfer over to the hotel. It is pet hotel but they don’t like it if pet is unattended in room. It was a good stay for the price."
Reviewed on May 19, 2026

Simple Rewards Inn Shelbina
711 North Highway 15 Shelbina MO
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $102 total per night from May 30 to May 31
$102 total
May 30 - May 31
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Cairo hotel reviews by fellow wanderers

Americas Best Value Inn & Suites Macon at Sunset Dr
3 out of 5
Posted 18 hours ago
Travelocity Verified Review
"The room was clean and property easy to get to other locations. Front desk was nice. I clicked on pet but didn’t transfer over to the hotel. It is pet hotel but they don’t like it if pet is unattended in room. It was a good stay for the price."
A verified traveler stayed at Americas Best Value Inn & Suites Macon at Sunset Dr
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