Explore top 2026 5 Star Hotels in Vatican City

Name: Villa Agrippina Gran Meliá - The Leading Hotels of the World
Price range: $541 total
Rating: 9.2

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Top Vatican City 5 Star hotels

The Westin Excelsior, Rome

Via Vittorio Veneto 125 Rome RM

Fully refundableReserve now, pay when you stay

$345 nightly

$403 total

Jan 23 - Jan 24

Total with taxes and fees

A full-service spa, an indoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...

8.2/10 Very Good! (741 reviews)

Spacious rooms!!!

Reviewed on Nov 19, 2025

NH Collection Roma Palazzo Cinquecento

Piazza Dei Cinquecento, 90 Rome RM

Fully refundableReserve now, pay when you stay

$271 nightly

$322 total

Jan 11 - Jan 12

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. There's ...

9/10 Wonderful! (1,000 reviews)

The room was great.

Reviewed on Dec 7, 2025

Sofitel Rome Villa Borghese

Via Lombardia 47 Rome RM

Fully refundableReserve now, pay when you stay

$299 nightly

$353 total

Jan 18 - Jan 19

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Families will appreciate the onsite laundry facilities, kid-friendly dining, and in-room childcare. ...

9/10 Wonderful! (945 reviews)

Overall 10/10

Reviewed on Aug 27, 2025

Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World

Piazza Della Repubblica, 47 Rome RM

Fully refundableReserve now, pay when you stay

$620 nightly

$706 total

Jan 12 - Jan 13

Total with taxes and fees

A full-service spa, 2 restaurants, and a gym are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, free WiFi in ...

9/10 Wonderful! (997 reviews)

incredible, no hotel compares to it. everything was perfect

Reviewed on Dec 13, 2025

InterContinental Rome Ambasciatori Palace by IHG

Via V. Veneto 62 Rome RM

Fully refundable

$469 nightly

$539 total

Jan 27 - Jan 28

Total with taxes and fees

The hotel's 24-hour gym, a rooftop terrace, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the free WiFi in public ...

9.4/10 Exceptional! (160 reviews)

Breakfast was fresh, room always clean and staff very attentive. Definitely will be staying here again!!!

Reviewed on Dec 19, 2025

W Rome

26/36 Via Liguria Rome RM

Fully refundableReserve now, pay when you stay

$469 nightly

$539 total

Jan 25 - Jan 26

Total with taxes and fees

This hotel features 2 bars/lounges, a poolside bar, and a restaurant. Enjoy the 24-hour gym and perks like free WiFi. Enjoy the a rooftop terrace and conveniences ...

9.4/10 Exceptional! (205 reviews)

Room was clean but it’s kind of dark. It would be nice to have a lamp for extra light as I was in the 1st floor with only a small window. Staff is nice but I was incredibly disappointed that the rooftop was closed for the season. Nothing about the rooftop being seasonal was mentioned on the website. ...

Reviewed on Dec 1, 2025

Baglioni Hotel Regina - The Leading Hotels of the World

Via Vittorio Veneto 72 Rome RM

Fully refundableReserve now, pay when you stay

$396 nightly

$459 total

Jan 7 - Jan 8

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities and in-room ...

8.8/10 Excellent! (500 reviews)

Room,staff

Reviewed on Dec 29, 2025

Radisson Collection Hotel, Roma Antica

VIA DELLE BOTTEGHE OSCURE 46 Rome RM

Fully refundableReserve now, pay when you stay

$254 nightly

$303 total

Jan 27 - Jan 28

Total with taxes and fees

This smoke-free hotel features 2 restaurants and 2 bars/lounges. Enjoy the a rooftop terrace and perks like free WiFi. Enjoy the steam room and conveniences ...

9.4/10 Exceptional! (149 reviews)

Great staff clean rooms

Reviewed on Dec 23, 2025

Six Senses Rome

Piazza di San Marcello Rome RM

Fully refundableReserve now, pay when you stay

$1,175 nightly

$1,316 total

Jan 9 - Jan 10

Total with taxes and fees

A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Enjoy the a rooftop terrace and perks like free WiFi. You'll appreciate ...

9.4/10 Exceptional! (59 reviews)

This was our first time staying at a Six Senses hotel and we will definitely consider staying at this hotel brand for future travel. The staff were hospitable, kind, and helpful. The food was excellent. The amenities were great.

Reviewed on Dec 26, 2025

Villa Agrippina Gran Meliá - The Leading Hotels of the World

Via del Gianicolo 3 Rome RM

Fully refundableReserve now, pay when you stay

$471 nightly

$541 total

Jan 10 - Jan 11

Total with taxes and fees

A full-service spa, 4 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Business travelers can take advantage of the free WiFi in public ...

9.2/10 Wonderful! (928 reviews)

Staff are really pleasant and accommodating. Especially, Frederick, Andrea and Emma. Staff in the restaurant Follie, Mario and Marco provided exceptional service throughout the evening. Also, staff during breakfast were very friendly.

Reviewed on Nov 26, 2025

Don't see what you're looking for?

See all available properties in Vatican City

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vatican City Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Vatican City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Vatican City 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Vatican City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.