Explore top 2025 4 Star Hotels in Mediterranean Region

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Top Mediterranean Region 4 Star hotels

Barcelona Airport Hotel

Barcelona Airport Hotel

4 out of 5
Plaza de la Volateria, 3 El Prat de Llobregat
Fully refundableReserve now, pay when you stay
This smoke-free hotel features 2 restaurants, a bar/lounge, and a gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
8.6/10 Excellent! (5,066 reviews)
Excellent stay

Reviewed on Nov 12, 2025

Opens in a new windowBarcelona Airport Hotel
Hotel Regina

Hotel Regina

4 out of 5
Alcala 19 Madrid Madrid
Fully refundableReserve now, pay when you stay
$264 nightly
The price is $291 total per night from Dec 14 to Dec 15
$291 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and ...
9.6/10 Exceptional! (2,194 reviews)
Breakfast

Reviewed on Nov 10, 2025

Opens in a new windowHotel Regina
Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
$133 nightly
The price is $164 total per night from Nov 16 to Nov 17
$164 total
Nov 16 - Nov 17
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. WiFi in public areas is free. A business center, a coffee shop, and a terrace are also on offer.
8.4/10 Very Good! (1,000 reviews)
Staff was so kind!

Reviewed on Nov 12, 2025

Opens in a new windowNapoleon Hotel
Hotel Emperador

Hotel Emperador

4 out of 5
Gran Via 53 Madrid Madrid
This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
9.2/10 Wonderful! (1,836 reviews)
Fruits, everything good.

Reviewed on Nov 13, 2025

Opens in a new windowHotel Emperador
Hotel Quirinale

Hotel Quirinale

4 out of 5
Via Nazionale 7 Rome RM
$139 nightly
The price is $171 total per night from Dec 14 to Dec 15
$171 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 6 conference rooms, free WiFi in public areas, and laundry ...
8.6/10 Excellent! (1,908 reviews)
The hotel is great and all the amenities wonderful thank you for the hospitality

Reviewed on Nov 11, 2025

Opens in a new windowHotel Quirinale
Bettoja Hotel Mediterraneo

Bettoja Hotel Mediterraneo

4 out of 5
Via Cavour 15 Rome RM
Fully refundableReserve now, pay when you stay
This Art Deco hotel features 2 restaurants, a bar/lounge, and a gym. Families will appreciate the onsite laundry facilities and babysitting. Enjoy the a rooftop ...
8.6/10 Excellent! (995 reviews)
Big room, clean and comfortable. Very good location

Reviewed on Nov 5, 2025

Opens in a new windowBettoja Hotel Mediterraneo
citizenM Rome Isola Tiberina

citizenM Rome Isola Tiberina

4 out of 5
LUNGOTEVERE DE CENCI 5-8 Rome RM
Fully refundableReserve now, pay when you stay
$161 nightly
The price is $194 total per night from Nov 30 to Dec 1
$194 total
Nov 30 - Dec 1
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.4/10 Exceptional! (751 reviews)
Cappuccino in the morning and a clean, quiet room. They allowed us an early check in too.

Reviewed on Nov 7, 2025

Opens in a new windowcitizenM Rome Isola Tiberina
Hotel Liabeny

Hotel Liabeny

4 out of 5
Calle de la Salud 3 Madrid
Fully refundableReserve now, pay when you stay
This hotel features a restaurant, a sauna, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
9.2/10 Wonderful! (1,448 reviews)
Was great

Reviewed on Nov 12, 2025

Opens in a new windowHotel Liabeny
Grupotel Mayorazgo

Grupotel Mayorazgo

4 out of 5
Flor Baja 3 Madrid Madrid
Fully refundableReserve now, pay when you stay
$209 nightly
The price is $230 total per night from Nov 24 to Nov 25
$230 total
Nov 24 - Nov 25
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Self parking, ...
8.4/10 Very Good! (775 reviews)
Nice stay

Reviewed on Nov 9, 2025

Opens in a new windowGrupotel Mayorazgo
The Hoxton Poblenou

The Hoxton Poblenou

4 out of 5
Avinguda Diagonal 205 Barcelona
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $181 total per night from Dec 6 to Dec 7
$181 total
Dec 6 - Dec 7
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and an outdoor pool. Traveling on business? Take advantage of the 7 conference rooms, free WiFi in ...
9/10 Wonderful! (551 reviews)
Overall great experience! The staff were helpful and the facility is really well kept.

Reviewed on Nov 14, 2025

Opens in a new windowThe Hoxton Poblenou
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4 Star Hotels Mediterranean Region

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Mediterranean Region 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Mediterranean Region will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Mediterranean Region, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Mediterranean Region hotel reviews by fellow wanderers