
$178 Cheap American Airlines flights from Greenville to Detroit (GSP to DTW)
Find The Best Day To Fly from Greenville to Detroit
Amazing American Airlines GSP to DTW Flight Deals
The cheapest flights to Detroit Metropolitan Wayne County found within the past 7 days were $282 round trip and $178 one way. Prices and availability subject to change. Additional terms may apply.
GSP
Greenville
DTW
Detroit
$282 Roundtrip, found 5 days ago
$282
Roundtrip
found 5 days ago
GSP
Greenville
DTW
Detroit
$306 Roundtrip, found 6 days ago
$306
Roundtrip
found 6 days ago
GSP
Greenville
DTW
Detroit
$315 Roundtrip, found 17 hours ago
$315
Roundtrip
found 17 hours ago
GSP
Greenville
DTW
Detroit
$317 Roundtrip, found 3 days ago
$317
Roundtrip
found 3 days ago
GSP
Greenville
DTW
Detroit
$325 Roundtrip, found 17 hours ago
$325
Roundtrip
found 17 hours ago
GSP
Greenville
DTW
Detroit
$334 Roundtrip, found 6 days ago
$334
Roundtrip
found 6 days ago
DTW From GSP Economy Coach Packages on Similar Airlines
Price found within the past 48 hours. Click for updated prices.



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Travelers ❤️ these 🏨 after their flight to Detroit

La Quinta Inn & Suites by Wyndham Detroit Metro Airport
30847 Flynn Drive, Romulus, MI
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and a free airport shuttle. Traveling on business? Take advantage ...
8.2/10 Very Good! (2,196 reviews)
"Missed our connecting flight and had to get a hotel room at midnight to spend the night with my wife and two young children. Called the hotel to get their shuttle service and were picked up less than 10 minutes later. The lady working the desk at midnight was incredibly helpful and very accommodating. ..."
Reviewed on Jul 16, 2025

Radisson Hotel Detroit Metro Airport
8800 Wickham Rd, Romulus, MI
This hotel doesn't skimp on freebies - guests receive free WiFi, free self parking, and a free airport shuttle. Traveling for business? Take advantage of the ...
7.2/10 Good! (1,009 reviews)
"Clean cozy quiet , and fair priced ."
Reviewed on Jul 15, 2025

The Westin Detroit Metropolitan Airport
2501 Worldgateway Pl, Detroit, MI
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (1,011 reviews)
"Very convenient to airport"
Reviewed on Jul 17, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top American Airlines Flight Routes from DTW
- American Airlines DTW to TPA
- American Airlines DTW to MCO
- American Airlines DTW to RSW
- American Airlines DTW to CUN
- American Airlines DTW to LAX
- American Airlines DTW to FLL
- American Airlines DTW to SJU
- American Airlines DTW to MIA
- American Airlines DTW to LAS
- American Airlines DTW to DFW
- American Airlines DTW to PHX
Top Flights for American Airlines originating from GSP
Domestic
- New York to Orlando (JFK - MCO)
- Newark Liberty Intl. Airport to Las Vegas (EWR - LAS)
- Chicago to Las Vegas (ORD - LAS)
- Philadelphia to Orlando (PHL - MCO)
- New York to Santiago (JFK - STI)
- Dallas to Las Vegas (DFW - LAS)
- Boston to Orlando (BOS - MCO)
- Los Angeles to Honolulu (LAX - HNL)
- Orlando to San Juan (MCO - SJU)
- Philadelphia to Orlando (PHL - MCO)
International
- Philadelphia to San Juan (PHL - SJU)
- San Juan to Orlando (SJU - MCO)
- Newark Liberty Intl. Airport to Santiago (EWR - STI)
- Dallas to Las Vegas (DFW - LAS)
- New York to Santiago (JFK - STI)
- Orlando to San Juan (MCO - SJU)
- New York to Orlando (JFK - MCO)
- New York to San Juan (JFK - SJU)
- Philadelphia to Orlando (PHL - MCO)
- New York to Orlando (LGA - MCO)
Most Popular
Flights
- San Diego to Charleston (SAN - CHS)
- Charleston to Atlanta (CHS - ATL)
- Atlanta to Charleston (ATL - CHS)
- Flint to Orlando (FNT - MCO)
- Charleston to New York (CHS - JFK)
- Boston to Myrtle Beach (BOS - MYR)
- Detroit to Charleston (DTW - CHS)
- Hartford to Myrtle Beach (BDL - MYR)
- Atlanta to Myrtle Beach (ATL - MYR)
- New York to Charleston (JFK - CHS)
- Newark Liberty Intl. Airport to Myrtle Beach (EWR - MYR)
- Charleston to Philadelphia (CHS - PHL)
- Chicago to Myrtle Beach (ORD - MYR)
- American Airlines New York (JFK) to Myrtle Beach (MYR) flights
- Baltimore to Myrtle Beach (BWI - MYR)
- Cleveland to Myrtle Beach (CLE - MYR)
- JetBlue Airways North Charleston (CHS) to Boston (BOS) flights
- Charleston to Miami (CHS - MIA)
- Chicago to Charleston (ORD - CHS)
- Syracuse to Myrtle Beach (SYR - MYR)
- Pittsburgh to Myrtle Beach (PIT - MYR)
- JetBlue Airways Boston (BOS) to North Charleston (CHS) flights
- JetBlue Airways Tampa (TPA) to North Charleston (CHS) flights
- Philadelphia to Charleston (PHL - CHS)
- Detroit to Myrtle Beach (DTW - MYR)
- Philadelphia to Myrtle Beach (PHL - MYR)
- Grand Rapids to Orlando (GRR - MCO)
- Charleston to Orlando (CHS - MCO)
- Grand Rapids to Denver (GRR - DEN)
- Grand Rapids to Miami (GRR - MIA)