Explore 50 Luxury Hotels in Southern Minnesota

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Best Luxury Hotels in Southern Minnesota

Brentwood Inn & Suites

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $122 total per night from Jan 29 to Jan 30
$122 total
Jan 29 - Jan 30
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast and free WiFi. Business travelers can take advantage of the 24-hour business ...
8.8/10 Excellent! (1,005 reviews)
Ok, my rating is purely based on the proximity to the Mayo Clinic. If you are looking for an updated chain hotel with its typical amenites (gym, newer tv) this is not it. It is a place that definitely shows its age. However, it is clean, quiet, has helpful staff, and a better than expected daily ...

Reviewed on Jan 21, 2026

Opens in a new windowBrentwood Inn & Suites
Kahler Grand Hotel

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Jan 29 to Jan 30
$146 total
Jan 29 - Jan 30
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.2/10 Very Good! (1,861 reviews)
Check in went smooth, the rooms were clean, and we enjoyed the hot tub and sauna

Reviewed on Jan 26, 2026

Opens in a new windowKahler Grand Hotel
AmericInn by Wyndham Northfield

AmericInn by Wyndham Northfield

1320 Bollenbacher Dr Northfield MN
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Feb 1 to Feb 2
$109 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
8.2/10 Very Good! (626 reviews)
Good

Reviewed on Jan 15, 2026

Opens in a new windowAmericInn by Wyndham Northfield
Super 8 by Wyndham Jackson MN

Super 8 by Wyndham Jackson MN

2025 Highway 71 N Jackson MN
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $88 total per night from Jan 28 to Jan 29
$88 total
Jan 28 - Jan 29
Total with taxes and fees
This motel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
8/10 Very Good! (603 reviews)
Room was clean

Reviewed on Dec 26, 2025

Opens in a new windowSuper 8 by Wyndham Jackson MN
AmericInn by Wyndham Blue Earth

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $79 total per night from Feb 1 to Feb 2
$79 total
Feb 1 - Feb 2
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
7.8/10 Good! (462 reviews)
All good.

Reviewed on Dec 5, 2025

Opens in a new windowAmericInn by Wyndham Blue Earth
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $86 total per night from Jan 31 to Feb 1
$86 total
Jan 31 - Feb 1
Total with taxes and fees
2 indoor pools, a 24-hour gym, and a hot tub are all featured at this traditional motel. Bring the family and enjoy the children's pool, waterslide, and kid-friendly ...
7.8/10 Good! (1,007 reviews)
Same breakfast every day.

Reviewed on Jan 23, 2026

Opens in a new windowMed City Inn & Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Jan 28 to Jan 29
$152 total
Jan 28 - Jan 29
Total with taxes and fees
This hotel features an indoor pool and a gym. Business travelers can take advantage of the free WiFi in public areas. Enjoy the free self-serve breakfast each ...
7.8/10 Good! (1,524 reviews)
Clean rooms, breakfast included, great location to Mayo Clinic

Reviewed on Jan 27, 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
Coratel Inn & Suites By Jasper Northfield

Coratel Inn & Suites By Jasper Northfield

1420 Riverview Dr Northfield MN
Fully refundableReserve now, pay when you stay
$39 nightly
The price is $44 total per night from Jan 30 to Jan 31
$44 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
6/10 (663 reviews)
Staff was very friendly, clean room just needed for a night cause of a snow storm, but great .

Reviewed on Jan 26, 2026

Opens in a new windowCoratel Inn & Suites By Jasper Northfield
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Southern Minnesota Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southern Minnesota luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southern Minnesota to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southern Minnesota will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southern Minnesota, and plan your next opulent escape.


Southern Minnesota hotels essential information

Accommodation
1,201 hotels
Lowest Price
$44
Highest Price
$152
Popular hotels
Kahler Grand Hotel, AmericInn by Wyndham Blue Earth, Med City Inn & Suites - Mayo Clinic Area, AmericInn by Wyndham Northfield, Super 8 by Wyndham Jackson MN, Coratel Inn & Suites By Jasper Northfield, Kahler Inn and Suites - Mayo Clinic Area, Brentwood Inn & Suites

Popular Luxury Stays in Southern Minnesota

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