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21C Museum Hotel St Louis

4.5 star property
4.5-star luxury hotel near St. Louis Union Station

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Massages
Exterior
Bar (on property)
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(109 reviews)
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(34 reviews)
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | In-room safe, desk, laptop workspace, blackout drapes

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 237 sq ft
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Library)

  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

A hotel room with a large bed, a green sofa, a small round table, and a large abstract painting on the wall.

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
4.4 out of 5, Excellent, 1,271 reviews
$127 nightly
The price is $151
May 24 - May 25
Total with taxes and fees
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About the neighborhood

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find St. Louis Union Station and City Museum. Busch Stadium and Gateway Arch are also within 2 miles (3 km).

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.1 miles
  • City Museum - 5 min walk - 0.3 miles
  • St. Louis Union Station - 8 min walk - 0.4 miles
  • Enterprise Center - 8 min walk - 0.5 miles
  • St. Louis Aquarium at Union Station - 11 min walk - 0.6 miles

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near St. Louis Union Station
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Hyatt Regency St. Louis at The Arch
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  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
4.3 out of 5, Excellent, 4,034 reviews
$127 nightly
The price is $149
May 25 - May 26
Total with taxes and fees
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Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM

Late check-in subject to availability

Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector, and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis

21c Museum St Louis St Louis

21C Museum Hotel St Louis Hotel

21C Museum Hotel St Louis St. Louis

21C Museum Hotel St Louis Hotel St. Louis

21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

How close is 21C Museum Hotel St Louis to the airport?

21C Museum Hotel St Louis is 18.4 mi (24-min drive) away from the St. Louis Lambert Intl. Airport (STL) airport, the closest popular airport to the property.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of May 14, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on May 25, 2026 start from $151, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21C Museum Hotel St Louis have an airport shuttle?

Airport shuttle services are not available at 21C Museum Hotel St Louis .

Does 21C Museum Hotel St Louis offer free breakfast?

Free breakfast isn’t provided at 21C Museum Hotel St Louis , but cooked-to-order breakfast is offered for a fee of between USD 10 and 25 per person. It's available every day from 6:30 AM to 1:00 PM.

Is there a casino at 21C Museum Hotel St Louis ?

No, there is no casino at this hotel, but Horseshoe St. Louis Casino (3-min drive) and Casino Queen (5-min drive) are nearby.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM.

Is there free parking at 21C Museum Hotel St Louis ?

Free parking is not available at this hotel. Valet parking is available for USD 50 per day.

Does 21C Museum Hotel St Louis have a pool?

21C Museum Hotel St Louis features an indoor pool.

Does 21C Museum Hotel St Louis have a restaurant?

Yes, there is a restaurant on site.

Does 21C Museum Hotel St Louis have a spa?

This hotel doesn't have a spa, but it does offer massages.

How close is 21C Museum Hotel St Louis to downtown St. Louis?

21C Museum Hotel St Louis is 0.4 mi away from St. Louis.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1292 out of 1832 reviews
Rating 8 - Good. 280 out of 1832 reviews
Rating 6 - Okay. 131 out of 1832 reviews
Rating 4 - Poor. 59 out of 1832 reviews
Rating 2 - Terrible. 70 out of 1832 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

10/10 Excellent

Sarah

Traveled with family and small children
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean and serviced daily. Hotel was lovely and well appointed.
Stayed 3 nights in Apr 2026

6/10 Okay

Angela

Traveled with partner
Liked: Cleanliness, property conditions & facilities
Clean room, bar was nice, drinks good. We had to wait 1 hour to check in. It threw off my whole night. We had dinner plans that had to be skipped to get to our event. I was hangry.
Stayed 1 night in Mar 2026

10/10 Excellent

Austin

Stayed 4 nights in Feb 2026

10/10 Excellent

Jake

Stayed 1 night in Jan 2026

10/10 Excellent

Chris

Stayed 1 night in Feb 2026

10/10 Excellent

Andreea I

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Everything was superlative. Staff, hotel, room, pool.
Stayed 2 nights in Feb 2026

10/10 Excellent

David

Stayed 1 night in Jan 2026

10/10 Excellent

Keely

Stayed 1 night in Feb 2026

10/10 Excellent

Michael

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
We loved this hotel. It is something you expect in much more sophisticated cities but not St. Louis. Our king bed suite was tastefully furnished and very large. Lots of great touches and very clean. The lobby and museum were stylish and exciting. We ate at both Idolwolf and the cafe. Again great ambiance and delicious food. Our visit was a one night staycation to celebrate our anniversary and it couldn’t have turned out better.
View of the bar on a Sunday morning
Stayed 1 night in Feb 2026

10/10 Excellent

Roger

Stayed 1 night in Feb 2026

10/10 Excellent

Diana

Liked: Cleanliness, property conditions & facilities
Room was clean stuff was friendly and everyone was super nice
Stayed 2 nights in Feb 2026

10/10 Excellent

Linda

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, unique hotel. Loved the esthetics and vibe of the entire building.
Stayed 1 night in Feb 2026

10/10 Excellent

Lauren

Stayed 1 night in Feb 2026

10/10 Excellent

Kimbriel

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Everything was great i can’t wait to stay again
Stayed 2 nights in Jan 2026

8/10 Good

Kurt

Stayed 1 night in Jan 2026

2/10 Terrible

Lauren

Disliked: Cleanliness, staff & service, amenities
Dirty room and I’ll mannered management. Not worth the money I’d rather stay at motel 6.
Stayed 1 night in Jan 2026

10/10 Excellent

Luz

Stayed 1 night in Jan 2026

8/10 Good

Lindsey

Stayed 3 nights in Jan 2026

10/10 Excellent

Meredith

Business traveler
Liked: Cleanliness, amenities, property conditions & facilities
Hotel was very quiet and staff helpful and courteous. The coffee shop was great for coffee and breakfast and the rooms were clean with hot water and great water pressure. The only thing I would change was the mattress - bed was very firm, kind of felt like lying on a table. Gallery was a fun feature and next time I'm in STL I will be back!
Stayed 1 night in Jan 2026

10/10 Excellent

Brad

Stayed 1 night in Jan 2026

10/10 Excellent

Michelle

Liked: Cleanliness, staff & service, amenities
Everything was perfect!
Stayed 2 nights in Jan 2026

10/10 Excellent

Brad

Traveled with family
Liked: Cleanliness, staff & service, amenities
We did have a great stay but one thing bothered us. While at the bar Friday night, a customer approximately 25-30 years old allowed her dog to run loose through the hotel while she sat at the bar drinking. When a customer brought the dog to the young lady, she sat the dog on the bar. When bar staff explained the dog was not allowed, the female became belligerent, threatening to assault at least one bartender, calling bar staff profane names. Bar staff cut her drinks off and asked her to leave. The female began recording staff from her cell phone and creating a disturbance with other patrons. After about 30 minutes, management called police. Police showed up and between hotel management and police, they allowed her to go back to her room. I felt like management did not support staff and the female should have been told to leave.
Stayed 2 nights in Jan 2026

10/10 Excellent

anthony

Liked: Cleanliness, amenities, property conditions & facilities
Clean room and the hotel itself is just gorgeous.
Stayed 1 night in Jan 2026

2/10 Terrible

Lauren

Disliked: Cleanliness, staff & service, amenities
Room was dirty and not properly stocked. Staff were extremely rude aside from the nice guys working in the breakfast spot. Manager is classless will never stay here again.
Stayed 1 night in Jan 2026

10/10 Excellent

John, Cincinnati

Stayed 1 night in Jan 2026