Sikeston Vacation Packages 2026 from $405

Sikeston flight + hotel vacation packages

Price found within the past 48 hours. Click for updated prices.

The Cheshire

Save 100% on your flight

$405

per person

Sep 10 - Sep 13

found 1 day ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and free English breakfast each morning.

The Wildwood Hotel

Save 100% on your flight

$574

per person

Sep 3 - Sep 7

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the hot tub and free perks like continental breakfast and free self parking.

Remodeled and Inviting Free EV

Save 100% on your flight

$491

per person

Sep 9 - Sep 13

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

This vacation home doesn't skimp on freebies - guests receive free WiFi and free self parking. A virtual front desk are provided for your convenience.

Hermann Grain Bins BNB

Save 100% on your flight

$781

per person

Oct 22 - Oct 25

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

This bed & breakfast features free WiFi in public areas, barbecue grills, and free self parking. Enjoy the free full breakfast each morning. A garden and a picnic area are also provided.

Lodge Of Four Seasons Golf Resort, Marina & Spa

Save 100% on your flight

$649

per person

Sep 17 - Sep 21

found 1 day ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

This resort features a golf course, a full-service spa, and a marina. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference space. You'll find 2 restaurants and 5 bars/lounges for dining and drinks, and an indoor pool is also on site.

Top Sikeston hotels deals

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$111 nightly

$128 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the gym and free perks like buffet breakfast and free self parking.

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$93 nightly

$106 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. A 24-hour business center, a grocery/convenience store, and express check-out are also on offer.

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$68 nightly

$78 total

Aug 16 - Aug 17

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the 3 onsite conference rooms. Enjoy the gym and conveniences like a 24-hour front desk and laundry facilities.

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$102 nightly

$115 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features an indoor pool and a gym. There's no skimping on freebies - guests receive free continental breakfast, free WiFi, and free self parking. A 24-hour business center, a snack bar/deli, and express check-out are also on offer.

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

Free Cancellation

$85 nightly

$96 total

Aug 23 - Aug 24

Total with taxes and fees

This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.

Fairfield Inn & Suites by Marriott Sikeston

1239 Commerce Drive Sikeston MO

Free Cancellation

Reserve now, pay when you stay

$110 nightly

$125 total

Aug 9 - Aug 10

Total with taxes and fees

This hotel features an indoor pool, a gym, and a restaurant. Business travelers can take advantage of the free WiFi in public areas. Relax with a drink at the bar/lounge and enjoy free perks like buffet breakfast and free self parking.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)

You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

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Frequently asked questions

How much are vacation packages to Sikeston?

Starting from as little as $405, flight and hotel packages are a fabulous way to make your travel budget stretch further. Sikeston, here you come!

How long should my Sikeston vacation be?

Generally, visitors stay 2 nights in Sikeston. Although, that might not be enough time for you. If you aim to explore some of the region's hidden treasures, why not add another few nights to your travel schedule?

Where can I get the best vacation package deals for Sikeston?

With around 400 airlines and 1,000,000 hotels across the world, it's hard to beat Travelocity. Make the most of our impressive range and create your dream Sikeston vacation package. Don't you love it when planning a trip is that easy?

Why should I purchase my Sikeston vacation bundle via Travelocity?

You'll not only enjoy big savings, but you can also access our 24/7 customer support, high-quality service and a Price Match Guarantee. Journey across the globe, discover hidden gems and make lifelong memories — we'll take care of the important details.

Can I save money on my Sikeston car rental if I book it with my hotel or flight?

Absolutely — combine your flight, hotel and car into a Sikeston vacation package and you can save a tidy sum. With so much to see and do in the Sikeston area, that rental car will come in handy. Once you've buckled yourself in, turn up the stereo and make your way to Orpheum Theatre, a famous sight roughly 120 mi from Sikeston.

Which airport is best for Sikeston?

Many vacationers arrive at Cape Girardeau Municipal Airport (CGI). After you've landed and grabbed your luggage, you'll need to head 25 mi south to reach downtown Sikeston. Barkley Regional Airport (PAH) is another option, 45 mi from the center of the city.

What is there to do in Sikeston?

There's an undeniable magic as you wander the streets of Sikeston. The Book Bug and Central Park are just a couple of famous sights that make this city such a sought-after destination, so put them at the top of your travel itinerary.

Where should I stay when visiting Sikeston?

The Pear Tree Inn Sikeston is recommended by many visitors. Book as soon as possible to avoid missing out.

Where to stay in Sikeston: Best areas for travelers

Miner: If you're in the mood for some sightseeing in this neighborhood, head straight for The Book Bug. It's just one reason many visitors stay here. We suggest checking out the rates and reviews of the Drury Inn & Suites Sikeston, MO, the Motel 6 Sikeston MO and the Pear Tree Inn Sikeston.
Charleston: This is a great neighborhood for your next getaway — not the busiest place around, but still highly rated by many travelers. For an enjoyable stay, make a reservation at the Quality Inn Charleston I-57 or the Super 8 by Wyndham Charleston MO.