Explore 38 Luxury Hotels in Upstate South Carolina
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Best Luxury Hotels in Upstate South Carolina
The Westin Poinsett Greenville
120 South Main St Greenville SC
Fully refundableReserve now, pay when you stay
$189 nightly
The price is $208 total per night from Mar 15 to Mar 16
$208 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free ...
9.2/10 Wonderful! (1,001 reviews)
Great location and beautiful hotel in downtown Greenville. Staff was very friendly and helpful.
Reviewed on Mar 2, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
$149 nightly
The price is $163 total per night from Mar 22 to Mar 23
$163 total
Mar 22 - Mar 23
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.8/10 Excellent! (1,005 reviews)
Great room, good price, nice staff.
Reviewed on Mar 1, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$101 nightly
The price is $111 total per night from Mar 15 to Mar 16
$111 total
Mar 15 - Mar 16
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
8.6/10 Excellent! (1,008 reviews)
The overall cleanliness of my room was subpar. There was hair, caked up dust and trash in my bathroom. The tub was very slippery, myself and grandchildren slipped several times while bathing. Several chips were under and behind the chair by the bed. The room felt pretty crowded for it to be for 4 ...
Reviewed on Mar 2, 2026
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr Greenville SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Apr 2 to Apr 3
$83 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the business ...
8/10 Very Good! (1,002 reviews)
Everything was great for me. No problems with the hotel or staff. My room was very clean and it was refreshed every day. My caretakers were rewarded every day as my room was excellent. I have been staying here off and on for years and it has always been good.
Reviewed on Mar 3, 2026
La Quinta Inn & Suites by Wyndham Greenville Haywood
65 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $84 total per night from Mar 9 to Mar 10
$84 total
Mar 9 - Mar 10
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self parking. ...
7.4/10 Good! (1,125 reviews)
Room was clean but rough around the edges. Friendly staff!
Reviewed on Mar 3, 2026
Red Roof Inn Spartanburg – I-26
6765 Pottery Rd Spartanburg SC
Fully refundableReserve now, pay when you stay
$61 nightly
The price is $67 total per night from Mar 18 to Mar 19
$67 total
Mar 18 - Mar 19
Total with taxes and fees
This hotel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free continental breakfast each morning. Staff at the 24-hour ...
7/10 Good! (752 reviews)
Almost perfect. Everyone was very nice and friendly and helpful. The refrigerator in the room had stuff spilled in it that we had to clean before using it. There was nothing in the soap, shampoo, conditioner and lotion bottles. Fortunately I had those things in my luggage and the guy at the front ...
Reviewed on Feb 15, 2026
Quality Inn Clemson near University
3430 Clemson Blvd Anderson SC
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $60 total per night from Mar 29 to Mar 30
$60 total
Mar 29 - Mar 30
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...
7/10 Good! (900 reviews)
The staff is wonderfully courteous, but the building and rooms need an infusion of cash to repaint, recarpet, repair and remodel. The facility is at the end of its days. You can only clean a rundown room so much before it just becomes a loss. No bugs or insects at all. Just stains and too many hasty ...
Reviewed on Mar 3, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Mar 15 to Mar 16
$109 total
Mar 15 - Mar 16
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
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See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More 4 star hotels in Upstate South Carolina
Designer Retreat w/ Pool, Golf + Beach Access!
Salem SC
10/10 Exceptional! (1 review)
Upstate South Carolina Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Upstate South Carolina luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Upstate South Carolina to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Upstate South Carolina will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Upstate South Carolina, and plan your next opulent escape.
Upstate South Carolina hotels essential information
Accommodation | 2,952 hotels |
|---|---|
Lowest Price | $60 |
Highest Price | $208 |
Popular hotels | The Westin Poinsett Greenville, Hyatt Regency Greenville, Sleep Inn at Greenville Convention Cente, Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG, Red Roof Inn Spartanburg – I-26, Quality Inn Clemson near University, La Quinta Inn & Suites by Wyndham Greenville Haywood, Hilton Greenville |
Popular Luxury Stays in Upstate South Carolina
Recent Upstate South Carolina Hotel Reviews By Fellow Wanderers
Hyatt Place Greenville/Haywood
5 out of 5
Posted 2 hours ago
Travelocity Verified Review
"Great "
A verified traveler stayed at Hyatt Place Greenville/Haywood
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