Book Hotels in Panacea, FL

Start date: Check-in selected.
To Date
End date: Check-out

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Panacea hotels

NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!

NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!

Panacea
A hot tub is featured at this vacation home, along with laundry facilities and barbecue grills.
This property was perfect. So fresh and awesome views. The best mattresses and pillows we have slept on in a long time. Very pet friendly. Great place to walk my dog. Wonderful kitchen.

Reviewed on Oct 19, 2025

Get rates
Opens in a new windowNEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!
Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.

Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.

Alligator Point
This vacation home featured laundry facilities and barbecue grills.
Great location and it was clean! Enjoyed the screen porch in the evenings. Fishing wasn’t that great this week but the pups sure did enjoy it! The host was a pleasure to work with and he went out of his way to accommodate us for our trip. Thank you again, Russ! :-)

Reviewed on Oct 11, 2025

Get rates
Opens in a new windowTiki House is a Unique Beach Front gathering spot for family, friends and PUPs.
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

Alligator Point
$1,769 nightly
The price is $1,934 total per night from Oct 27 to Oct 28
$1,934 total
Oct 27 - Oct 28
Total with taxes and fees
This vacation home features a garden, laundry facilities, and barbecue grills.
Love this house! Plenty of beds, great views and the house was stocked as well as I’ve ever seen in a rental property (I’m serious!!!). Thank you!

Reviewed on Oct 12, 2025

Opens in a new window7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

Panacea
This vacation home features a garden, laundry facilities, and barbecue grills.
We had such fun at this location and have already planned our return! This place was welcoming and clean and perfect for our family. Thank you

Reviewed on Sep 28, 2025

Get rates
Opens in a new window5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch
"Shifting Sands" Private Beach Front 3 Bd, 2 Bath, sleeps 8

"Shifting Sands" Private Beach Front 3 Bd, 2 Bath, sleeps 8

Alligator Point
This vacation home features a garden, laundry facilities, and barbecue grills.
CLose to beach

Reviewed on Oct 17, 2025

Get rates
Opens in a new window"Shifting Sands" Private Beach Front 3 Bd, 2 Bath, sleeps 8
Secluded Florida Beach Bungalow FALL SPECIAL 20% OFF!!

Secluded Florida Beach Bungalow FALL SPECIAL 20% OFF!!

Panacea
This vacation home features a garden, laundry facilities, and barbecue grills.
2nd time staying here and it was so beautiful we will definitely be back, everything was wonderful and the host was amazing.

Reviewed on Oct 11, 2025

Get rates
Opens in a new window Secluded Florida Beach Bungalow FALL SPECIAL 20% OFF!!
Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Panacea
This vacation home features a garden, laundry facilities, and barbecue grills.
We loved the location of the house and extra amenities like the pickle ball courts. Would highly recommend to anyone needing a relaxing reset!

Reviewed on Aug 24, 2025

Get rates
Opens in a new windowSkipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock
Ocean View- Your Front Row Seat to the Sea

Ocean View- Your Front Row Seat to the Sea

Panacea
This vacation home featured laundry facilities and barbecue grills.
Our plans had to change last minute with this property as there were some unpreventable, unforseeable issues which have since been addressed. However, Vacations by Waypoint was on top of things. They instantly booked another beach home 10 seconds down the road from this one for us. We ended up at ...

Reviewed on Sep 3, 2025

Get rates
Opens in a new windowOcean View- Your Front Row Seat to the Sea
The Panacea Motel

The Panacea Motel

2 out of 5
1545 Coastal Hwy, Panacea, FL
$113 nightly
The price is $127 total per night from Nov 3 to Nov 4
$127 total
Nov 3 - Nov 4
Total with taxes and fees
Stay at this motel in Panacea. Enjoy free WiFi, free parking, and hiking/biking on site. Popular attractions Panacea Springs and Woolley Park are located ...
Clean room

Reviewed on Oct 5, 2025

Opens in a new windowThe Panacea Motel
Don't see what you're looking for?
See all available properties in Panacea
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Panacea?
Family vacations are where the best memories are made, but it's no secret that traveling with youngsters can be difficult. These kid-friendly Panacea hotels come with perks designed to keep young and old alike comfortable and happy: Put your bags down at Tide Creek Lookout. It comes with a nearby beach, animal viewing activities and a talent for making families feel welcome. Also check out Gated Water View Pool Home on Dickerson Bay. It offers a swimming pool, a travel crib and plenty of opportunities for family time.
Where can I find cheap hotels in Panacea?
At Travelocity you'll find really nice hotels in Panacea at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Panacea rather than in Panacea. We may find you even better rates, too.
How do I find the best Panacea hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Panacea then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Panacea?
The cheapest hotel in Panacea is $127. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Panacea?
There are 527 hotels in Panacea on Travelocity.
What are the best hotels in Panacea?
Panacea has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Panacea for you!
When is the best time to visit Panacea?
If you want the joy of a fun-filled trip in peak season, visit Panacea during February, April and September. If you'd prefer the peace of off-season, book a stay during quieter months, such as July, October and November.
When is the cheapest time to stay in Panacea?
Based on historic data is usually the cheapest month to visit Panacea. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Panacea?
There are multiple hotels in Panacea that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Panacea. We have plenty of kid-friendly hotels in Panacea to choose from on Travelocity!
Why book a hotel in Panacea through Travelocity?
Because we have the top hotels in Panacea! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Panacea on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Panacea hotel reviews by fellow wanderers

NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!

NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!

5 out of 5
Posted 3 days ago
Travelocity Verified Review
"This property was perfect. So fresh and awesome views. The best mattresses and pillows we have slept on in a long time. Very pet friendly. Great place to walk my dog. Wonderful kitchen. "
A verified traveler stayed at NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!
NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!

Explore More Ways to Travel with Travelocity