Book Hotels in Panacea, FL
Cabins, apartments, houseboats! We offer comfortable & private vacation rentals
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Top Panacea hotels

Your Fall Escape: FSU Football & Scalloping
Alligator Point FL
This vacation home featured laundry facilities and barbecue grills.
"We enjoyed our stay here so much and we were very sad to go! The place was AMAZING! It is family friendly and pet friendly. The beach and ocean are right where you can see them and easy to access. Utilize the outdoor shower to helo with sand tracking in and out. The laundry room is located down stairs ..."
Reviewed on Aug 1, 2026

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
Alligator Point FL
$1,942 nightly
The price is $2,121 total per night from Oct 10 to Oct 11
$2,121 total
Oct 10 - Oct 11
Total with taxes and fees
This vacation home features a garden, laundry facilities, and barbecue grills.
"We had an amazing week. Best equipped home we have ever stayed. The privacy and peacefulness was just want we needed. Host was very responsive."
Reviewed on Aug 15, 2026

Hideaway Beach Cottage on waterfront with amazing views.
Panacea FL
This cottage features a garden, laundry facilities, and barbecue grills.
"Booking this stay was incredibly easy. Hosts are responsive and very accommodating. Price was great, especially considering that we thought the property was even better in person. Pictures truly don’t do it justice. The small town of Panacea is a breath of fresh air. Not your typical touristy beach ..."
Reviewed on Sep 23, 2026

Coastal Getaway on canal-steps to the beach
Panacea FL
This vacation home features a garden, laundry facilities, and barbecue grills.
"Awesome weekend staying at this location. We was within walking distance to the beach and fishing. Loved that it had a complete bathroom downstairs when we came in from fishing all day and night. Great communication with the host. Very prompt responding to questions. Will recommend to family and ..."
Reviewed on Sep 13, 2026

Best deal at Alligator Point
Alligator Point FL
This vacation home includes a garden and laundry facilities.
"Best kept secret! First time renter and will definitely be back. Great host, location was spot on, amazing bay views, fishing and super clean!"
Reviewed on Sep 8, 2026

Lighthouse- enjoy the water, bask in the view
Alligator Point FL
This vacation home featured laundry facilities and barbecue grills.
"A very remote location, laid back small community and very natural beaches."
Reviewed on Sep 27, 2026

BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.
Panacea FL
$571 nightly
The price is $624 total per night from Oct 20 to Oct 21
$624 total
Oct 20 - Oct 21
Total with taxes and fees
An outdoor pool is featured at this vacation home, along with a garden and laundry facilities.
"Charming beach house just steps away from the beach. The beach was quiet which is a great alternative to crowded beaches. Robin was very responsive and helpful. Would love to come back!"
Reviewed on Aug 1, 2026

Waterfront Home: Spectacular On-Site Fishing!
Panacea FL
This vacation home features a garden, laundry facilities, and barbecue grills.
"Great stay!"
Reviewed on Aug 27, 2026

The Panacea Motel
1545 Coastal Hwy Panacea FL
$109 nightly
The price is $121 total per night from Oct 13 to Oct 14
$121 total
Oct 13 - Oct 14
Total with taxes and fees
Stay at this motel in Panacea. Enjoy free WiFi, free parking, and hiking/biking on site. Popular attractions Panacea Springs and Woolley Park are located ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Panacea hotel reviews by fellow wanderers

Great sunrise view from dining area and decks. Easy beach access.
5 out of 5
Posted 10 days ago
Travelocity Verified Review
"Property is clean and in a great location for peace and quiet. We enjoyed meeting the host and I'm sure will book with them again."
A verified traveler stayed at Great sunrise view from dining area and decks. Easy beach access.
Explore More Ways to Travel with Travelocity
- Guesthouses in Panacea
- Aparthotels in Panacea
- The Panacea Motel
- Shifting Sands Private Beach Front 3 Bd 2 Bath sleeps 8
- Cabins in Wakulla County
- Hotels in Wakulla Springs
- Hotels near Wakulla Springs State Park
- Condos in Panacea
- Cabins in Panacea
- Hotels near Ochlockonee River State Park
- Hotels in Ochlockonee Bay
- Hotels near Florida State University
- Hotels near Florida State Capitol Building
- Hotels near Florida A&M University
- Hotels in Woodville
- Hotels in Wakulla Beach
- Hotels near Tallahassee Memorial Medical Center
- Hotels near Tallahassee FL
- Hotels in Tallahassee
- The Lodge at Wakulla Springs
- Sardegna- pool dock home by Mashes Sands Beach
- SALT AIR AND SERENDIPITY Unit B
- Pet Friendly in Panacea
- Ocean View in Panacea
- Legasea Old Florida Beachfront Charm with Two Screen Porches Sleeps 7
- Historical in Panacea
- Enchanted Cottage Beachfront Charming Retreat by the Sea
- Alligator Point Old Florida Beachfront Cottage
- Best deal at Alligator Point
- Turtles Nest BACK TO SCHOOL SPECIAL FOR AUGUST 23 2026-AUGUST 29 2026
- Hotels near St Marks Lighthouse
- Hotels in St Marks
- Hotels in St George Island
- Franklin Inn
- Buccaneer Inn
- Beach in St George Island
- Hotels in Sopchoppy
- Cottages in Crawfordville
- Hotels in Carrabelle
- Cabins in Crawfordville
- Apartments in Crawfordville
- Beach in Crawfordville
- Aparthotels in Crawfordville
- Hotels near Cascades Park
- Hotels near Bobby Bowden Field at Doak Campbell Stadium
- Hotels near Bald Point State Park
- Hotels near Apalachicola National Forest
- Pet Friendly in Tallahassee
- Motel 6 Tallahassee FL - Downtown
- Luxury in Tallahassee
- Hotels near Donald L Tucker Civic Center
- Privatevacationhomes in Dog Island
- Beach in Wakulla County
- Loyalty Inn Tallahassee
- Kitchenette in Tallahassee
- Motels in Crawfordville
- Hotels in Crawfordville
- Budget in Tallahassee
- Aparthotels in Tallahassee
- Hotels near St Marks National Wildlife Refuge
- Pet Friendly in Crawfordville
- Golf in Crawfordville
- Hotels in Apalachicola
- Cabins in Sopchoppy
- Motels in Saint Teresa
- Hotels in Saint Teresa
- Cottages in Saint Teresa
- Privatevacationhomes in Alligator Point
- Motels in Alligator Point
- Hotels in Alligator Point
- Condos in Alligator Point
- Condos in Saint Teresa
- Condos in Crawfordville
- Hotels in Quincy
- Privatevacationhomes in Panacea
- Motels in Panacea
- Secluded Florida Beach Bungalow-LABOR DAY WEEK OPEN 10 OFF
- Pelican Perch
- Beachfront Alligator Point Vacation Rental
- Beach in Panacea
- Bayside Retreat Panacea FL Bay Front Dock 2 Large Porches No Pets Wifi
- Bayfront Condo with Boat Slip
- CONDO Water front bay breeze fishing paradise and family friendly 2 bedroom
- AWESOME VIEW On Private Gulf of Mexico Beach Majestic Views
- Flights from Tampa (TPA) to Tallahassee (TLH)
- Flights from West Palm Beach (PBI) to Tallahassee (TLH)
- Flights from Miami (MIA) to Tallahassee (TLH)
- Flights from Orlando (MCO) to Tallahassee (TLH)
- Flights from Fort Lauderdale (FLL) to Tallahassee (TLH)
- Flights from Tallahassee FL
- Flights to Tallahassee
- Flights to Saint Teresa
- Flights to Panacea






