Book Hotels in Southwest Illinois, IL

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Southwest Illinois hotels

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from May 10 to May 11
$123 total
May 10 - May 11
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Very friendly spacious and clean! Great people

Reviewed on Apr 16, 2026

Opens in a new windowDrury Inn & Suites St. Louis O'Fallon, IL
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from Apr 26 to Apr 27
$115 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
The room was quiet and had comfortable beds. The free snacks (5:30 - 7:00) were delicious and enough for a meal. Breakfast was also excellent :)

Reviewed on Apr 16, 2026

Opens in a new windowDrury Plaza Hotel Mt. Vernon
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $78 total per night from May 10 to May 11
$78 total
May 10 - May 11
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Yes everything was wonderful

Reviewed on Apr 14, 2026

Opens in a new windowDrury Inn & Suites Marion
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $120 total per night from May 6 to May 7
$120 total
May 6 - May 7
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
Clean room! Super friendly staff! Easy access and parking!

Reviewed on Apr 17, 2026

Opens in a new windowDrury Inn & Suites St. Louis Fairview Heights
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
Fully refundable
$113 nightly
The price is $127 total per night from Apr 20 to Apr 21
$127 total
Apr 20 - Apr 21
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
The breakfast menu was typical. It wasn’t bad. The bats were great. The room was OK. Bathrooms were updated, but the carpet was in need of being pulled out. I had a lot of warning areas in the carpet in my room, especially since they accept dogs there I didn’t wanna walk on it.

Reviewed on Apr 17, 2026

Opens in a new windowComfort Suites Mount Vernon
Super 8 by Wyndham Troy IL/St. Louis Area

Super 8 by Wyndham Troy IL/St. Louis Area

2 out of 5
910 Edwardsville Rd Troy IL
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $80 total per night from Apr 26 to Apr 27
$80 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
The hotel was ready to access, rooms were adequate and breakfast was good.

Reviewed on Apr 16, 2026

Opens in a new windowSuper 8 by Wyndham Troy IL/St. Louis Area
Quality Inn & Suites near St. Louis and I-255

Quality Inn & Suites near St. Louis and I-255

2.5 out of 5
1607 Pontiac Dr East St. Louis IL
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $79 total per night from May 5 to May 6
$79 total
May 5 - May 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
The pool was closed, gym treadmill was broken, room smelled, toilet chain was off

Reviewed on Apr 7, 2026

Opens in a new windowQuality Inn & Suites near St. Louis and I-255
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50 O'Fallon IL
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $68 total per night from Apr 19 to Apr 20
$68 total
Apr 19 - Apr 20
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Plenty of shops near by, rooms mostly clean, bathrooms very small, shower head older model, plenty of security cameras.

Reviewed on Apr 13, 2026

Opens in a new windowQuality Inn O'Fallon IL - St. Louis
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
$51 nightly
The price is $59 total per night from Apr 26 to Apr 27
$59 total
Apr 26 - Apr 27
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
I had to yell for someone to come to the desk. The room was not clean and the sheets had stains. No bugs. The extra lock on the door as loose.

Reviewed on Apr 14, 2026

Opens in a new windowSuper 8 by Wyndham O'Fallon
Don't see what you're looking for?
See all available properties in Southwest Illinois
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Southwest Illinois hotels

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Southwest Illinois hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity