Book Hotels in Southwest Illinois, IL
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Top Southwest Illinois hotels
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $125 total per night from Feb 6 to Feb 7
$125 total
Feb 6 - Feb 7
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
Very clean room.. everyone was so nice and the kick back happy hour with free food a drinks. Wow both delicious and very appreciated. Great place to stay 10 out of 10
Reviewed on Jan 27, 2026
Drury Inn & Suites St. Louis O'Fallon, IL
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from Feb 8 to Feb 9
$123 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
The staff and was friendly and so helpful
Reviewed on Jan 22, 2026
Drury Inn & Suites Marion
2706 W DeYoung St Marion IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $113 total per night from Feb 8 to Feb 9
$113 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
The hotel was one of the cleanest I have been in! We enjoyed the breakfast and the evening meal.
Reviewed on Jan 25, 2026
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Feb 5 to Feb 6
$106 total
Feb 5 - Feb 6
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
All was good. Breakfast especially at 100%.
Reviewed on Jan 22, 2026
Comfort Suites Mount Vernon
404 South 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $123 total per night from Feb 3 to Feb 4
$123 total
Feb 3 - Feb 4
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Staff was so nice room clean
Reviewed on Jan 26, 2026
Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG
3396 Green Mount Crossing Drive Shiloh O'Fallon IL
Fully refundable
$118 nightly
The price is $131 total per night from Feb 23 to Feb 24
$131 total
Feb 23 - Feb 24
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Staff was great, will stay again
Reviewed on Jan 21, 2026
Quality Inn O'Fallon IL - St. Louis
1409 W US 50 O'Fallon IL
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $63 total per night from Feb 8 to Feb 9
$63 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
Great place to stay, very helpful ataff!
Reviewed on Jan 17, 2026
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
6 Gateway Dr Collinsville IL
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $90 total per night from Feb 8 to Feb 9
$90 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
The room seemed claen. The bed was great, everything was great. Except for the shower, when they did a remodel they made the shower door slide the wrong way. There is zero chance of turning the water on without getting blast of cold sprayed on you! So that made me think, i see the cleaners in the ...
Reviewed on Jan 12, 2026
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
$47 nightly
The price is $54 total per night from Feb 8 to Feb 9
$54 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Yes
Reviewed on Jan 24, 2026
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See all available properties in Southwest Illinois
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Southwest Illinois hotels
Motel 6 Caseyville, IL - Caseyville Il
2431 Old Country Inn Dr Caseyville IL
$60 nightly
The price is $68 total per night from Feb 4 to Feb 5
$68 total
Feb 4 - Feb 5
Total with taxes and fees
6.2/10 (1,001 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Southwest Illinois with star-rating
Check Southwest Illinois Hotels by Star Rating
4 Star Hotels
4 properties
Recent Southwest Illinois hotel reviews by fellow wanderers
Drury Plaza Hotel Mt. Vernon
5 out of 5
Posted 5 days ago
Travelocity Verified Review
"Very clean room.. everyone was so nice and the kick back happy hour with free food a drinks. Wow both delicious and very appreciated. Great place to stay 10 out of 10"
A verified traveler stayed at Drury Plaza Hotel Mt. Vernon
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