Book Hotels in Southwest Illinois, IL
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Top Southwest Illinois hotels
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $125 total per night from Sep 20 to Sep 21
$125 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy ...
"G"
Reviewed on Sep 15, 2026
Drury Inn & Suites St. Louis O'Fallon, IL
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from Sep 20 to Sep 21
$123 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"Room was nicely decorated and clean, bed and pillows very comfortable, staff friendly and helpful, breakfast was delicious. Only downside was air conditioning loud with a scratching sound with blower"
Reviewed on Sep 14, 2026
Drury Inn & Suites St. Louis Collinsville
602 N Bluff Rd Collinsville IL
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Sep 20 to Sep 21
$128 total
Sep 20 - Sep 21
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"Room was clean, breakfast/kick back were excellent and the staff is very friendly."
Reviewed on Sep 14, 2026
Drury Inn & Suites Marion
2706 W DeYoung St Marion IL
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $78 total per night from Sep 27 to Sep 28
$78 total
Sep 27 - Sep 28
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Booked the room on Expedia only to get to the hotel to check in to be told “they had over booked, sorry”. Not only were we left without a room we were also charged for the room. We have yet to receive a refund or get a response from anyone after we were “promise we didn’t charge you”."
Reviewed on Sep 14, 2026
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Sep 28 to Sep 29
$106 total
Sep 28 - Sep 29
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"The amenities where excellent and offered more then other places offer. The staff were kind d and friendly. The rooms where clean, comfortable, and up to what you wa t feom a hotel stay.I would stay there again."
Reviewed on Sep 13, 2026
Comfort Inn Edwardsville - St. Louis
3080 S State Route 157 Edwardsville IL
$92 nightly
The price is $106 total per night from Sep 21 to Sep 22
$106 total
Sep 21 - Sep 22
Total with taxes and fees
This hotel features an indoor pool and a 24-hour gym. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
"Great property that met all my expectations and had very kind staff."
Reviewed on Sep 15, 2026
Quality Inn O'Fallon - St. Louis - Shiloh
1409 W US 50 O'Fallon IL
Fully refundable
$67 nightly
The price is $77 total per night from Oct 5 to Oct 6
$77 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...
"Nice people but it’s been almost 2 weeks since a refund was supposed to reach my account already but still has not. Supposedly released on Sept. 3rd the day we spoke face to face but have yet to receive refund on a room and security deposit. Don’t like that every time I call their number then click ..."
Reviewed on Sep 15, 2026
Quality Inn & Suites near St. Louis and I-255
1607 Pontiac Dr East St. Louis IL
Fully refundable
$75 nightly
The price is $85 total per night from Oct 5 to Oct 6
$85 total
Oct 5 - Oct 6
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Guests will ...
"Room was clean, however the room had a damaged lock, shower rod, the toilet wouldnt stop running, and there was staining on the walls by the closet door frame. I also did not have a remote to the tv in the room. Room 129 Sheets were clean. Bed was comfy. Staff were excellent! Reechie checked me in ..."
Reviewed on Sep 14, 2026
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
$54 nightly
The price is $62 total per night from Sep 21 to Sep 22
$62 total
Sep 21 - Sep 22
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
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See all available properties in Southwest Illinois
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Southwest Illinois hotels
Motel 6 Caseyville, IL - Caseyville Il
2431 Old Country Inn Dr Caseyville IL
$62 nightly
The price is $70 total per night from Oct 1 to Oct 2
$70 total
Oct 1 - Oct 2
Total with taxes and fees
6.4/10 (1,004 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Southwest Illinois with star-rating
Check Southwest Illinois Hotels by Star Rating
4 Star Hotels
3 properties
Recent Southwest Illinois hotel reviews by fellow wanderers
Quality Inn O'Fallon - St. Louis - Shiloh
4 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Nice people but it’s been almost 2 weeks since a refund was supposed to reach my account already but still has not. Supposedly released on Sept. 3rd the day we spoke face to face but have yet to receive refund on a room and security deposit. Don’t like that every time I call their number then click option 2 the phone always hangs up no matter the day or time. Please if anyone at the hotel working there can see this review please try to reach out to me so we can resolve this or know what’s going on."
A verified traveler stayed at Quality Inn O'Fallon - St. Louis - Shiloh
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