Explore 12 Luxury Hotels in Southeast Missouri
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Best Luxury Hotels in Southeast Missouri
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
"Great location - very clean and well stocked with all essentials. Will stay again"
Reviewed on Sep 28, 2026
Motel 6 Poplar Bluff, MO
"The hallways reeked of marijuana smoke. Changed hotels the second night."
Reviewed on Nov 2, 2026
Super 8 by Wyndham Poplar Bluff Missouri
"Very dirty hotel. Check in staff was not friendly and I wanted to turn around just by how unwelcoming she was. We were traveling with a tiny toy poodle that she made sound like an inconvenience when she was the cleanest thing in the whole hotel. The stairs and hallways were very dirty and stinky. ..."
Reviewed on Oct 28, 2026
Super 8 by Wyndham Pevely
"Room was not clean. Used soap bars in shower. Room was just nasty although heard from other people there rooms were nice. So evidently we had one that had not been renovated. The refrigerator did not work warmer inside than room and tried adjusting nothing. The sink had been painted and was peeling. ..."
Reviewed on Oct 25, 2026
Days Inn and Suites by Wyndham Sikeston
Comfort Inn Festus - St Louis South
Baymont by Wyndham Festus
Quality Inn Cape Girardeau North
Southeast Missouri Luxury Hotels
Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southeast Missouri luxury hotels are the plush oasis you’ve been looking for.
Choose from the best luxury hotels in Southeast Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.
We want you to enjoy your next vacation in style and the top luxury resorts in Southeast Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southeast Missouri, and plan your next opulent escape.
Southeast Missouri hotels essential information
Accommodation | 695 hotels |
|---|---|
Lowest Price | $67 |
Highest Price | $88 |
Popular hotels | Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Baymont by Wyndham Festus, Quality Inn Cape Girardeau North |
