Explore 12 Luxury Hotels in Southeast Missouri

Name: Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Address: Cape Girardeau

Best Luxury Hotels in Southeast Missouri

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$58 nightly

$66 total

Jun 2 - Jun 3

Total includes taxes and fees

A seasonal outdoor pool is featured at this hotel, along with free WiFi in public areas and express check-out. Staff at the 24-hour front desk can provide around-the-clock ...

8.8/10 Excellent! (1,006 reviews)

"Clean and comfortable"

Reviewed on May 26, 2025

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Fully refundableReserve now, pay when you stay

$79 nightly

$83 total

May 31 - Jun 1

Total includes taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...

7.8/10 Good! (1,004 reviews)

"Overall good for the price. Your staff was professional"

Reviewed on May 23, 2025

Comfort Inn Festus - St Louis South

1303 Veterans Blvd, Festus, MO

Fully refundableReserve now, pay when you stay

$93 nightly

$106 total

Jun 15 - Jun 16

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...

7.8/10 Good! (815 reviews)

"The bed was very comfortable. Breakfast was very good lots of choices."

Reviewed on May 22, 2025

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Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr, Sikeston, MO

Fully refundableReserve now, pay when you stay

$81 nightly

$92 total

Jun 1 - Jun 2

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,002 reviews)

"Nice and clean"

Reviewed on Apr 14, 2025

Quality Inn Festus

1200 W Gannon Dr, Festus, MO

This hotel features an indoor pool and a gym. Families will appreciate the arcade/game room and barbecue grills. Relax with a drink at the bar/lounge and enjoy ...

6.8/10 (896 reviews)

"Great place to stay"

Reviewed on Apr 13, 2025

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Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd, Poplar Bluff, MO

Fully refundableReserve now, pay when you stay

$62 nightly

$70 total

Jun 9 - Jun 10

Total includes taxes and fees

This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...

6.6/10 (558 reviews)

"Easy place to get in and out to go shopping"

Reviewed on May 5, 2025

Super 8 by Wyndham Pevely

1711 Highway Z, Pevely, MO

This motel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...

5.6/10 (820 reviews)

Adequate

"Hotel is in rough shape…but if you just need a place to sleep for the night it will fulfill that. Hotel needs a major revamping."

Reviewed on May 17, 2025

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Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau

This apartment features a water park, laundry facilities, and barbecue grills.

Perfect stay!!

"We enjoyed this property so much!! The location was perfect, it was so clean, very accommodating, perfect amount of space, and awesome host! We were in town for AAU basketball and this rental gave us the comfort of being at home. The washer/dryer availability was a plus after sweaty ballgames! We ..."

Reviewed on May 4, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southeast Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southeast Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southeast Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southeast Missouri, and plan your next opulent escape.

Southeast Missouri hotels essential information

Accommodation	572 hotels
Lowest Price	$66
Highest Price	$106
Popular hotels	Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Quality Inn Festus