Explore 12 Luxury Hotels in Southeast Missouri

Name: Baymont by Wyndham Festus
Price range: $74 total
Rating: 6.8

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Best Luxury Hotels in Southeast Missouri

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

This apartment featured laundry facilities and barbecue grills.

10/10 Exceptional! (227 reviews)

"This was a great place to stay in the historical downtown Cape area! The location was very convenient to many shops and restaurants and the property was very well taken care of and clean. We look forward to staying here again!"

Reviewed on Jun 18, 2026

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Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$75 nightly

$84 total

Jun 28 - Jun 29

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed ...

8/10 Very Good! (1,001 reviews)

"The motel was great, however, they did not have blankets for the beds and the shower head left a lot to be desired. We would stay here again."

Reviewed on Jun 15, 2026

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

Fully refundable

$73 nightly

$83 total

Jul 16 - Jul 17

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business ...

7.8/10 Good! (956 reviews)

"It was fine, bed could have been more comfy, no mattress pad."

Reviewed on Jun 23, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Fully refundableReserve now, pay when you stay

$68 nightly

$78 total

Jul 1 - Jul 2

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of the ...

7.2/10 Good! (1,001 reviews)

"Rooms are nice and clean although fixtures could be updated. There is no central air and heat, room is cooled by a wall unit. Room was extremely hot when I first entered."

Reviewed on Jun 24, 2026

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$68 nightly

$76 total

Jul 5 - Jul 6

Total with taxes and fees

An outdoor pool, free self parking, and laundry facilities are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi ...

7/10 Good! (766 reviews)

"At 915 pm on a Friday night maintenance was using a hammer drill in concrete...just irritating and very loud!"

Reviewed on Jun 22, 2026

Baymont by Wyndham Festus

1200 W. Gannon Drive Festus MO

Fully refundableReserve now, pay when you stay

$65 nightly

$74 total

Jul 19 - Jul 20

Total with taxes and fees

This hotel features an indoor pool and a gym. Families will appreciate the arcade/game room and barbecue grills. Relax with a drink at the bar/lounge and enjoy ...

6.8/10 (978 reviews)

"Pool needed to be cleaned homeless people living out back that can look in the windows homeless people walking around picking up cigarette butts off the ground. Otherwise the room was decent and look like they had construction going on trying to clean up parts of remodel parts of the hotel."

Reviewed on Jun 21, 2026

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO

Fully refundableReserve now, pay when you stay

$55 nightly

$62 total

Jul 12 - Jul 13

Total with taxes and fees

This motel doesn't skimp on freebies - guests receive free on-the-go breakfast, free WiFi, and free self parking. Business travelers can take advantage of the ...

6.6/10 (651 reviews)

"The place was clean and the bed was comfy. Room was updated."

Reviewed on Jun 25, 2026

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

$75 nightly

$86 total

Jul 19 - Jul 20

Total with taxes and fees

This motel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...

5.6/10 (855 reviews)

"Had a suite... one bed was fine, the other had spring issues. Pull out couch was placed in a spot that it couldn't pull out because a bed was in the way. Front desk was not available when we needed to request more towels. Breakfast was sub par, with no protein or fruit options. Fitness center was ..."

Reviewed on Jun 20, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Missouri Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Southeast Missouri luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Southeast Missouri to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Southeast Missouri will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Southeast Missouri, and plan your next opulent escape.

Southeast Missouri hotels essential information

Accommodation	672 hotels
Lowest Price	$62
Highest Price	$86
Popular hotels	Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Baymont by Wyndham Festus, Quality Inn Cape Girardeau North

Popular Luxury Stays in Southeast Missouri

5 Stars Luxury stays in Southeast Missouri

Luxury stays in Southeast Missouri with spa

Recent Southeast Missouri Hotel Reviews By Fellow Wanderers

Drury Inn & Suites Sikeston, MO

5 out of 5

Posted 11 days ago

Travelocity Verified Review

"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

A verified traveler stayed at Drury Inn & Suites Sikeston, MO