Book Hotels in Santa Clara
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Top Santa Clara hotels

The Executive Hotel
Calle 52 Panama City Panama
Fully refundable
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Great location and the staff was really accommodating
Reviewed on Jan 25, 2026

Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from Feb 8 to Feb 9
$151 total
Feb 8 - Feb 9
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Hotel and rooms where keep clean. The staff was very nice and welcoming
Reviewed on Jan 23, 2026

Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $243 total per night from Feb 21 to Feb 22
$243 total
Feb 21 - Feb 22
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
awesome location, great staff
Reviewed on Jan 12, 2026

Las Americas Golden Tower Panama
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $132 total per night from Feb 5 to Feb 6
$132 total
Feb 5 - Feb 6
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center ...
Good place to stay for medical services as Paitilla Medical Center, Paitilla Hospital and Royal Center Medical Offices are all within 5 minutes walking. Sushi restaurant on the entry level is excellent.
Reviewed on Jan 18, 2026

W Panama
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $228 total per night from Feb 7 to Feb 8
$228 total
Feb 7 - Feb 8
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
Suite was spacious, clean, and the staff was exceptional.
Reviewed on Jan 16, 2026

Waymore Hotel Spa & Casino
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $95 total per night from Jan 31 to Feb 1
$95 total
Jan 31 - Feb 1
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
The room was kept so clean daily and the location was easy for day tours to pick me up from The hotel floors were quiet and so clean and always smelt delicious
Reviewed on Jan 20, 2026

Sheraton Grand Panama
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$134 nightly
The price is $148 total per night from Feb 13 to Feb 14
$148 total
Feb 13 - Feb 14
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
Great staff
Reviewed on Jan 15, 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $119 total per night from Feb 2 to Feb 3
$119 total
Feb 2 - Feb 3
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...
All very good and great value! Great location too.
Reviewed on Jan 12, 2026

Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$432 nightly
The price is $432 total per night from Feb 24 to Feb 25
$432 total
Feb 24 - Feb 25
Total with taxes and fees
A full-service spa, a nightclub, and 4 outdoor pools are all featured at this all-inclusive property. Spend a day at the beach kayaking, or relax with free beach ...
Everything was great very relaxing hotel staff very nice.
Reviewed on Jan 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Santa Clara hotel reviews by fellow wanderers

The Executive Hotel
5 out of 5
Posted 16 hours ago
Travelocity Verified Review
"Great location and the staff was really accommodating"
A verified traveler stayed at The Executive Hotel
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