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Top Santa Clara hotels

The Executive Hotel
Calle 52 Panama City Panama
Fully refundable
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Great stay overall. Attentive staff, great breakfast, extremely clean rooms. Great free parking. Would stay again for sure.
Reviewed on Mar 11, 2026

Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$151 nightly
The price is $166 total per night from Apr 12 to Apr 13
$166 total
Apr 12 - Apr 13
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
It was an excellent area overall for staying.
Reviewed on Mar 12, 2026

W Panama
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $219 total per night from Mar 31 to Apr 1
$219 total
Mar 31 - Apr 1
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
The hotel was fine. The hallway on the 19th floor had a weird odor, which I believe hotel was aware of because an air purifier was always there. One could hardly sleep most nights due to the guests in the end room next to us. They had booming music that woke us up, with altercations and door slamming ...
Reviewed on Mar 12, 2026

Principe Hotel and Suites
Via Argentina Panama City Panama
Fully refundableReserve now, pay when you stay
$57 nightly
The price is $62 total per night from Mar 16 to Mar 17
$62 total
Mar 16 - Mar 17
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
Hotel was very clean and staff was very kind
Reviewed on Mar 12, 2026

Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$206 nightly
The price is $226 total per night from Mar 28 to Mar 29
$226 total
Mar 28 - Mar 29
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
Excellent hotel, staff, and re
Reviewed on Mar 12, 2026

Waymore Hotel Spa & Casino
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Apr 3 to Apr 4
$105 total
Apr 3 - Apr 4
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this smoke-free bed & breakfast. Traveling on business? Take advantage of the free ...
Great quiet hotel. Pool a decent size and never crowded. No nice relaxing evening bar was the only disadvantage. Metro near. Good room. Would stay again.
Reviewed on Mar 13, 2026

Sheraton Grand Panama
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $139 total per night from Apr 3 to Apr 4
$139 total
Apr 3 - Apr 4
Total with taxes and fees
A full-service spa, 3 restaurants, and 3 outdoor tennis courts are all featured at this smoke-free resort. Families will appreciate the playground, kid-friendly ...
Clean and comfortable room. Bathroom needs an overall. Faucets are hard to open and close.
Reviewed on Mar 7, 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $119 total per night from Mar 23 to Mar 24
$119 total
Mar 23 - Mar 24
Total with taxes and fees
This smoke-free hotel features a casino, a full-service spa, and 3 restaurants. Families will appreciate the children's pool, onsite laundry facilities, and ...
Yes
Reviewed on Mar 12, 2026

Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$363 nightly
The price is $363 total per night from Apr 13 to Apr 14
$363 total
Apr 13 - Apr 14
Total with taxes and fees
This all-inclusive property features a full-service spa, a nightclub, and 7 restaurants. Spend a day at the beach kayaking, or relax with free beach cabanas ...
Rooms were a bit outdated and maintained moisture making it constantly feel damp. Walls needed some cleaning and tending to. However the staff was excellent and very
Reviewed on Mar 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Santa Clara hotel reviews by fellow wanderers

Waymore Hotel Spa & Casino
4 out of 5
Posted 8 hours ago
Travelocity Verified Review
"Great quiet hotel. Pool a decent size and never crowded. No nice relaxing evening bar was the only disadvantage. Metro near. Good room. Would stay again. "
A verified traveler stayed at Waymore Hotel Spa & Casino
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