Explore top 2026 5 Star Hotels in Panama Canal Zone

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Top Panama Canal Zone 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
$122 nightly
The price is $135 total per night from Jan 18 to Jan 19
$135 total
Jan 18 - Jan 19
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (4,815 reviews)
Very helpful staff

Reviewed on Jan 11, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$221 nightly
The price is $243 total per night from Jan 30 to Jan 31
$243 total
Jan 30 - Jan 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,010 reviews)
Yes the room was spotless and syaff was very attentive and courteous

Reviewed on Jan 8, 2026

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $219 total per night from Jan 30 to Jan 31
$219 total
Jan 30 - Jan 31
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
8.8/10 Excellent! (1,000 reviews)
The room was beautiful with a breathtaking view. The shower flow and hot water could be better along with the drainage system, but that was the only small flaws. We would certainly stay again!

Reviewed on Jan 3, 2026

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$309 nightly
The price is $340 total per night from Feb 7 to Feb 8
$340 total
Feb 7 - Feb 8
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,012 reviews)
Overall okay. The elevators are horrible. They don’t communicate well re: what is included, amenities, food, etc. Pools are beautiful, housekeeping was great.

Reviewed on Jan 4, 2026

Opens in a new windowJW Marriott Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$319 nightly
The price is $351 total per night from Feb 1 to Feb 2
$351 total
Feb 1 - Feb 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (572 reviews)
The staf, the people on the main entrance door, the concierne, everything is perfect.

Reviewed on Jan 5, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $232 total per night from Jan 16 to Jan 17
$232 total
Jan 16 - Jan 17
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,000 reviews)
Amazing location in downtown Panama City. Staff is super

Reviewed on Jan 4, 2026

Opens in a new windowHilton Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$254 nightly
The price is $280 total per night from Jan 25 to Jan 26
$280 total
Jan 25 - Jan 26
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,019 reviews)
Remarkable facility but greatly underutilized and understaffed. Service is very slow.

Reviewed on Jan 4, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $138 total per night from Jan 26 to Jan 27
$138 total
Jan 26 - Jan 27
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (113 reviews)
Yes

Reviewed on Jan 6, 2026

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$195 nightly
The price is $215 total per night from Feb 11 to Feb 12
$215 total
Feb 11 - Feb 12
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,000 reviews)
Room, valet parking and service were excellent. Breakfast was ok, just poor food variety.

Reviewed on Jan 5, 2026

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
$262 nightly
The price is $288 total per night from Feb 6 to Feb 7
$288 total
Feb 6 - Feb 7
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (648 reviews)
this is the best place to stay near the airport. great rooms, fantastic staff. The best breakfast ever! this is not my first time at Santa Maria and definitely not the last!!!

Reviewed on Dec 11, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Panama Canal Zone Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama Canal Zone hotel reviews by fellow wanderers