Explore top 2026 5 Star Hotels in Panama Canal Zone

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Top Panama Canal Zone 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
$147 nightly
The price is $162 total per night from Mar 31 to Apr 1
$162 total
Mar 31 - Apr 1
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (5,094 reviews)
This hotel was amazingly beautiful I would choose to stay here again

Reviewed on Mar 9, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
$196 nightly
The price is $216 total per night from Apr 4 to Apr 5
$216 total
Apr 4 - Apr 5
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,003 reviews)
The hotel was wonderful. The entire hotel was clean, staff welcoming especially security employee Flash. The breakfast buffet was great and it was so nice that Divney the receptionist remembered our names each day. My overall stay was great and I would highly recommend this hotel to anyone visiting ...

Reviewed on Feb 23, 2026

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$199 nightly
The price is $219 total per night from Mar 31 to Apr 1
$219 total
Mar 31 - Apr 1
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
9/10 Wonderful! (1,019 reviews)
Staff not friendly

Reviewed on Mar 6, 2026

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$237 nightly
The price is $261 total per night from Apr 5 to Apr 6
$261 total
Apr 5 - Apr 6
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,004 reviews)
Highly recommended

Reviewed on Mar 3, 2026

Opens in a new windowJW Marriott Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
$219 nightly
The price is $241 total per night from Mar 29 to Mar 30
$241 total
Mar 29 - Mar 30
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,004 reviews)
It prolly was a bad ass place once, but that was a while back. Room was ample, breakfast was very decent, place was generally clean. Our keys went outta whack four times, ride the elevator on someone else’s key up and down, go to reception, wasted ten minutes every time. No apologies whatsoever, ...

Reviewed on Feb 28, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $140 total per night from Apr 1 to Apr 2
$140 total
Apr 1 - Apr 2
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (166 reviews)
Yes there where shops nearby and the activities are more fir ages 18 and up

Reviewed on Mar 3, 2026

Opens in a new windowRenaissance Panama City Hotel
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$378 nightly
The price is $416 total per night from Apr 10 to Apr 11
$416 total
Apr 10 - Apr 11
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (608 reviews)
Had a lovely stay

Reviewed on Mar 8, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$178 nightly
The price is $195 total per night from Apr 2 to Apr 3
$195 total
Apr 2 - Apr 3
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,006 reviews)
Ocean view but no room cleaning and servicing until after 5 and 6 pm.

Reviewed on Mar 9, 2026

Opens in a new windowHilton Panama
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $191 total per night from Apr 10 to Apr 11
$191 total
Apr 10 - Apr 11
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.4/10 Exceptional! (1,006 reviews)
The pool area is bad

Reviewed on Mar 3, 2026

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
$235 nightly
The price is $258 total per night from Apr 10 to Apr 11
$258 total
Apr 10 - Apr 11
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (673 reviews)
All good. Morning buffet was crazy busy

Reviewed on Mar 3, 2026

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Panama Canal Zone Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama Canal Zone hotel reviews by fellow wanderers