Explore top 2026 5 Star Hotels in Panama Canal Zone
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Top Panama Canal Zone 5 Star hotels
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$138 nightly
The price is $151 total per night from May 5 to May 6
$151 total
May 5 - May 6
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (5,366 reviews)
Very nice
Reviewed on Apr 27, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$271 nightly
The price is $298 total per night from May 8 to May 9
$298 total
May 8 - May 9
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
9/10 Wonderful! (1,001 reviews)
The hotel is a bit tired in some areas
Reviewed on Apr 21, 2026
Hyatt Regency Panama City
Calle 52 and Ricardo Arias Panama City
Fully refundableReserve now, pay when you stay
$164 nightly
The price is $181 total per night from May 9 to May 10
$181 total
May 9 - May 10
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.6/10 Exceptional! (282 reviews)
I love the cleanliness of the hotel. The staff was very helpful, knowledgeable, n was able to understand and reply to questions in english. I will not stay at this hotel next time for 2 reasons. First reason being the water was only coming at room temperature when taking a shower n the AC never came ...
Reviewed on Apr 28, 2026
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$247 nightly
The price is $272 total per night from May 16 to May 17
$272 total
May 16 - May 17
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
9/10 Wonderful! (1,004 reviews)
Very good. 5star
Reviewed on Apr 26, 2026
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$329 nightly
The price is $361 total per night from May 25 to May 26
$361 total
May 25 - May 26
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (640 reviews)
It was just beautiful !
Reviewed on Apr 27, 2026
W Panama
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$244 nightly
The price is $269 total per night from May 29 to May 30
$269 total
May 29 - May 30
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
9/10 Wonderful! (1,009 reviews)
Everything was perfect went for my birthday and enjoyed myself they even surprised me with a cake 10 thumbs up 👍
Reviewed on Apr 27, 2026
The Westin Playa Bonita Panama
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$195 nightly
The price is $214 total per night from May 4 to May 5
$214 total
May 4 - May 5
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,003 reviews)
Okay I knew i only did breakfast and not all inclusive but it took forever to get a drink by the pool, someone walked by maybe every 30 minutes. There's really not any activities or shows but met some friendly staff V from water aerobics and C (I think) from Karaoke. Only ordered lunch once but it ...
Reviewed on Apr 24, 2026
Renaissance Panama City Hotel
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $140 total per night from May 3 to May 4
$140 total
May 3 - May 4
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.6/10 Excellent! (200 reviews)
staying at the Renaissance Hotel was amazing the hotel is beautiful the area is safe from the front desk to the kitchen everyone treats you like royalty I had a fabulous time I enjoyed every moment a big shoutout too the entire staff of the Renaissance hotel keep up the great service thank you for ...
Reviewed on Apr 26, 2026
Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $204 total per night from May 3 to May 4
$204 total
May 3 - May 4
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.4/10 Exceptional! (1,002 reviews)
Stay was excellent, nice big room and good amenities.
Reviewed on Apr 22, 2026
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $252 total per night from May 8 to May 9
$252 total
May 8 - May 9
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
9/10 Wonderful! (1,006 reviews)
This Hilton adheres to the best Hilton Standards- everything spot on.
Reviewed on Apr 24, 2026
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Panama Canal Zone Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Panama Canal Zone hotel reviews by fellow wanderers
Hyatt Regency Panama City
3 out of 5
Posted 1 hour ago
Travelocity Verified Review
"I love the cleanliness of the hotel. The staff was very helpful, knowledgeable, n was able to understand and reply to questions in english. I will not stay at this hotel next time for 2 reasons. First reason being the water was only coming at room temperature when taking a shower n the AC never came cold."
A verified traveler stayed at Hyatt Regency Panama City
