Explore top 2026 5 Star Hotels in Panama Canal Zone
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Top Panama Canal Zone 5 Star hotels
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $136 total per night from Aug 25 to Aug 26
$136 total
Aug 25 - Aug 26
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (5,791 reviews)
"The location and the availability of staff for assistance… navigating around the city was a breeze but, the lobby can get a bit crowded in the evening, which negatively impacts the luxury vibe the hotel tries to promote . The crown level is supposedly off limit to regular patrons; that, to me, is ..."
Reviewed on Jul 29, 2026
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$275 nightly
The price is $303 total per night from Aug 29 to Aug 30
$303 total
Aug 29 - Aug 30
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
W Panama
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$269 nightly
The price is $296 total per night from Aug 8 to Aug 9
$296 total
Aug 8 - Aug 9
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
9/10 Wonderful! (1,002 reviews)
"Amazing hotel, best mocktails at the rooftop bar, staff was amazing! Location in Panama City central - lots of restaurants close by. The coffee shop downstairs have the best pastries. Staying there again this winter when we return to Panama."
Reviewed on Jul 29, 2026
Sofitel Legend Casco Viejo, Panama City
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$375 nightly
The price is $413 total per night from Jul 30 to Jul 31
$413 total
Jul 30 - Jul 31
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
Renaissance Panama City Hotel
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $140 total per night from Aug 6 to Aug 7
$140 total
Aug 6 - Aug 7
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
$263 nightly
The price is $290 total per night from Aug 29 to Aug 30
$290 total
Aug 29 - Aug 30
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
Hyatt Regency Panama City
Calle 52 and Ricardo Arias Panama City Panamá Province
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $191 total per night from Aug 22 to Aug 23
$191 total
Aug 22 - Aug 23
Total with taxes and fees
This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...
9.6/10 Exceptional! (388 reviews)
"Unsurpassed interior modelling with a clean, modern and inviting ambience. Uber clean, close to subway, restaurants and financial district. Great gym."
Reviewed on Jul 29, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
$269 nightly
The price is $296 total per night from Jul 31 to Aug 1
$296 total
Jul 31 - Aug 1
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (720 reviews)
"The carpet in the rooms were dirty. The madewere coming at 10 o’clock at night to clean places and they were talking on their cell phone. You can hear it in the room."
Reviewed on Jul 29, 2026
Hilton Panama
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
$245 nightly
The price is $270 total per night from Aug 22 to Aug 23
$270 total
Aug 22 - Aug 23
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
The Westin Playa Bonita Panama
Km 6 Road to Veracruz Veracruz Panama
$206 nightly
The price is $227 total per night from Aug 18 to Aug 19
$227 total
Aug 18 - Aug 19
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,008 reviews)
"Breakfast buffet was great 👍 Selection of choices and taste of the food are five stars"
Reviewed on Jul 27, 2026
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Panama Canal Zone Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Panama Canal Zone hotel reviews by fellow wanderers
Hotel Riu Plaza Panama
5 out of 5
Posted 1 hour ago
Travelocity Verified Review
"The location and the availability of staff for assistance… navigating around the city was a breeze but, the lobby can get a bit crowded in the evening, which negatively impacts the luxury vibe the hotel tries to promote . The crown level is supposedly off limit to regular patrons; that, to me, is a big negative"
A verified traveler stayed at Hotel Riu Plaza Panama
