Explore top 2025 5 Star Hotels in Panama Canal Zone

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Top Panama Canal Zone 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $117 total per night from Nov 18 to Nov 19
$117 total
Nov 18 - Nov 19
Total with taxes and fees
This smoke-free hotel includes 3 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9/10 Wonderful! (4,478 reviews)
Great staff

Reviewed on Nov 8, 2025

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
$171 nightly
The price is $189 total per night from Dec 1 to Dec 2
$189 total
Dec 1 - Dec 2
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities, kid-friendly ...
8.8/10 Excellent! (1,002 reviews)
Very beautiful room was spotless, and staff was very good with customer service

Reviewed on Nov 7, 2025

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
$164 nightly
The price is $181 total per night from Dec 13 to Dec 14
$181 total
Dec 13 - Dec 14
Total with taxes and fees
This luxury hotel features 2 restaurants, 3 hot tubs, and an outdoor pool. Make the most of the gym and a rooftop terrace, and relax with drinks at one of the ...
8.8/10 Excellent! (1,003 reviews)
Room was great. Front desk was a little mean.

Reviewed on Nov 8, 2025

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
$197 nightly
The price is $217 total per night from Dec 7 to Dec 8
$217 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features 3 restaurants, 4 outdoor pools, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, express ...
8.8/10 Excellent! (1,000 reviews)
The receptionist and all the staff were very helpful. The property and room was stunning. Loved the pools and the gym. Would definitely stay here again.

Reviewed on Nov 7, 2025

Opens in a new windowJW Marriott Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $128 total per night from Nov 21 to Nov 22
$128 total
Nov 21 - Nov 22
Total with taxes and fees
A casino and an outdoor pool are featured at this luxury hotel. Families will appreciate the arcade/game room, onsite laundry facilities, and in-room childcare. ...
8.8/10 Excellent! (79 reviews)
N/A

Reviewed on Oct 29, 2025

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $175 total per night from Dec 6 to Dec 7
$175 total
Dec 6 - Dec 7
Total with taxes and fees
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the 24-hour business center, ...
9.2/10 Wonderful! (1,003 reviews)
Everything was good. We were satisfied

Reviewed on Nov 8, 2025

Opens in a new windowBristol Panama, a Registry Collection Hotel
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
$293 nightly
The price is $322 total per night from Dec 15 to Dec 16
$322 total
Dec 15 - Dec 16
Total with taxes and fees
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.8/10 Exceptional! (529 reviews)
The staff was fantastic and catered to our every need. The pool was and we received fantastic service there despite it being busy.

Reviewed on Nov 9, 2025

Opens in a new windowSofitel Legend Casco Viejo, Panama City
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $183 total per night from Dec 10 to Dec 11
$183 total
Dec 10 - Dec 11
Total with taxes and fees
This luxury hotel features a private beach, a full-service spa, and 4 restaurants. Enjoy beachfront dining and relax with sun loungers and beach umbrellas. There's ...
8/10 Very Good! (1,003 reviews)
Rooms were great! A/C felt AMAZING! Staff SUPER NICE AND FRIENDLY! FOOD AMAZING! There was literally nothing we ate that we did not love! We added the Premium all inclusive package when we arrived for a great price! We ate at all the restaurants, buffets and had top shelf liquor ! I would for sure ...

Reviewed on Nov 11, 2025

Opens in a new windowThe Westin Playa Bonita Panama
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
$179 nightly
The price is $196 total per night from Dec 7 to Dec 8
$196 total
Dec 7 - Dec 8
Total with taxes and fees
This luxury hotel features an attached winery, a casino, and a full-service spa. Families will appreciate the onsite laundry facilities and babysitting. Enjoy ...
8.8/10 Excellent! (1,001 reviews)
This hotel is perfection - in every respect. The best location, best amenities, awesome food, great entertainment, excellent service.

Reviewed on Oct 16, 2025

Opens in a new windowHilton Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard, Panama City
Fully refundableReserve now, pay when you stay
$172 nightly
The price is $189 total per night from Dec 13 to Dec 14
$189 total
Dec 13 - Dec 14
Total with taxes and fees
This luxury hotel features a golf course, a full-service spa, and 2 restaurants. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
9.6/10 Exceptional! (626 reviews)
This is a quality hotel with quality service. Recommend it

Reviewed on Oct 30, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Panama Canal Zone Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Panama Canal Zone to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama Canal Zone 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Panama Canal Zone before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama Canal Zone hotel reviews by fellow wanderers