Explore top 2025 5 Star Hotels in Mediterranean Region

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Top Mediterranean Region 5 Star hotels

Grand Hyatt Athens

Grand Hyatt Athens

5 out of 5
115, Syngrou Avenue Athens Attica
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $116 total per night from Nov 20 to Nov 21
$116 total
Nov 20 - Nov 21
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, free ...
8.6/10 Excellent! (962 reviews)
Clean room, courteous staff

Reviewed on Nov 13, 2025

Opens in a new windowGrand Hyatt Athens
The Palace, a Luxury Collection Hotel, Madrid

The Palace, a Luxury Collection Hotel, Madrid

5 out of 5
Plaza de las Cortes, 7 Madrid Madrid
Fully refundableReserve now, pay when you stay
$367 nightly
The price is $404 total per night from Dec 1 to Dec 2
$404 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
9/10 Wonderful! (999 reviews)
Beautiful place to stay, great location, excellent breakfast under the glass dome, wonderful staff!

Reviewed on Nov 9, 2025

Opens in a new windowThe Palace, a Luxury Collection Hotel, Madrid
Hyatt Regency Barcelona Tower

Hyatt Regency Barcelona Tower

5 out of 5
Gran Via 144 L'Hospitalet de Llobregat
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $185 total per night from Nov 30 to Dec 1
$185 total
Nov 30 - Dec 1
Total with taxes and fees
This luxury hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Enjoy the seasonal outdoor pool and perks like free WiFi. Self parking, a business ...
8.8/10 Excellent! (1,021 reviews)
Great

Reviewed on Nov 9, 2025

Opens in a new windowHyatt Regency Barcelona Tower
Lamaro Hotel

Lamaro Hotel

5 out of 5
Avenida Catedral, 7 Barcelona
Fully refundableReserve now, pay when you stay
$281 nightly
The price is $328 total per night from Dec 3 to Dec 4
$328 total
Dec 3 - Dec 4
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 2 conference rooms, free WiFi in public areas, ...
9.4/10 Exceptional! (1,787 reviews)
The staff was really friendly and rooms were clean. Close to all locations!! Buffet was excellent!! Would back again

Reviewed on Nov 12, 2025

Opens in a new windowLamaro Hotel
Barceló Torre de Madrid

Barceló Torre de Madrid

5 out of 5
Plaza de España, 18 Madrid
Fully refundable
$222 nightly
The price is $245 total per night from Dec 14 to Dec 15
$245 total
Dec 14 - Dec 15
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9.4/10 Exceptional! (2,225 reviews)
Was very good 👍

Reviewed on Nov 12, 2025

Opens in a new windowBarceló Torre de Madrid
Only YOU Hotel Sevilla

Only YOU Hotel Sevilla

5 out of 5
Avenida De Kansas City No.7 Seville Seville
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $168 total per night from Dec 1 to Dec 2
$168 total
Dec 1 - Dec 2
Total with taxes and fees
This hotel features an outdoor pool, a gym, and a restaurant. Families will appreciate the playground, onsite laundry facilities, and babysitting. Relax with ...
9.6/10 Exceptional! (553 reviews)
Booked after 10pm due to an AirBnB disaster. Luckily, reception is staffed full-time. Room was quiet, shower was lovely, vibe was awesome, and staff was helpful. It wasn't in our preferred area for tourism, but I would stay there again and walk the mile to the city center, due to how quiet it ...

Reviewed on Nov 13, 2025

Opens in a new windowOnly YOU Hotel Sevilla
Nobu Hotel Barcelona

Nobu Hotel Barcelona

5 out of 5
Avenida de Roma 2-4 Barcelona Barcelona
Fully refundableReserve now, pay when you stay
$230 nightly
The price is $273 total per night from Dec 1 to Dec 2
$273 total
Dec 1 - Dec 2
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Relax with a drink at one of the 2 bars/lounges and get perks like free WiFi. ...
8.8/10 Excellent! (1,145 reviews)
Great facilities, food & service. The staff were very friendly & helped us find everything from local restaurants, attractions & get us a taxi. We will come back for sure on our next trip to Barcelona.’

Reviewed on Nov 9, 2025

Opens in a new windowNobu Hotel Barcelona
Sofitel Athens Airport

Sofitel Athens Airport

5 out of 5
Athens International Airport Spata-Artemida Attiki
Fully refundableReserve now, pay when you stay
$242 nightly
The price is $279 total per night from Dec 16 to Dec 17
$279 total
Dec 16 - Dec 17
Total with taxes and fees
A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.4/10 Exceptional! (2,609 reviews)
One of the nicest bathrooms I’ve had in a hotel!

Reviewed on Nov 15, 2025

Opens in a new windowSofitel Athens Airport
Eurostars Barcelona Central

Eurostars Barcelona Central

5 out of 5
Calle Aragon 300 Barcelona
Fully refundableReserve now, pay when you stay
$163 nightly
The price is $198 total per night from Nov 24 to Nov 25
$198 total
Nov 24 - Nov 25
Total with taxes and fees
This hotel features a restaurant, a seasonal outdoor pool, and a bar/lounge. Enjoy the a rooftop terrace and perks like free WiFi. There's a poolside bar on ...
9/10 Wonderful! (563 reviews)
The room was very clean, and the staff was friendly and helpful. We loved the location, and would definitely stay here again.

Reviewed on Nov 14, 2025

Opens in a new windowEurostars Barcelona Central
Grand Hyatt Barcelona

Grand Hyatt Barcelona

5 out of 5
Plaza de Pio XII, 4 Barcelona
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $252 total per night from Nov 23 to Nov 24
$252 total
Nov 23 - Nov 24
Total with taxes and fees
A full-service spa, 2 restaurants, and an indoor pool are all featured at this luxury hotel. Enjoy the gym and perks like free WiFi. Enjoy the seasonal outdoor ...
9.2/10 Wonderful! (1,441 reviews)
Excellent stay!

Reviewed on Nov 11, 2025

Opens in a new windowGrand Hyatt Barcelona
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Mediterranean Region Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Mediterranean Region to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Mediterranean Region 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Mediterranean Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Mediterranean Region hotel reviews by fellow wanderers