Explore top 2025 5 Star Hotels in Mediterranean Region
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Top Mediterranean Region 5 Star hotels
Grand Hyatt Athens
Clean room, courteous staff
Reviewed on Nov 13, 2025
The Palace, a Luxury Collection Hotel, Madrid
Beautiful place to stay, great location, excellent breakfast under the glass dome, wonderful staff!
Reviewed on Nov 9, 2025
Hyatt Regency Barcelona Tower
Great
Reviewed on Nov 9, 2025
Lamaro Hotel
The staff was really friendly and rooms were clean. Close to all locations!! Buffet was excellent!! Would back again
Reviewed on Nov 12, 2025
Barceló Torre de Madrid
Was very good 👍
Reviewed on Nov 12, 2025
Only YOU Hotel Sevilla
Booked after 10pm due to an AirBnB disaster. Luckily, reception is staffed full-time. Room was quiet, shower was lovely, vibe was awesome, and staff was helpful. It wasn't in our preferred area for tourism, but I would stay there again and walk the mile to the city center, due to how quiet it ...
Reviewed on Nov 13, 2025
Nobu Hotel Barcelona
Great facilities, food & service. The staff were very friendly & helped us find everything from local restaurants, attractions & get us a taxi. We will come back for sure on our next trip to Barcelona.’
Reviewed on Nov 9, 2025
Sofitel Athens Airport
One of the nicest bathrooms I’ve had in a hotel!
Reviewed on Nov 15, 2025
Eurostars Barcelona Central
The room was very clean, and the staff was friendly and helpful. We loved the location, and would definitely stay here again.
Reviewed on Nov 14, 2025
Grand Hyatt Barcelona
Excellent stay!
Reviewed on Nov 11, 2025
Mediterranean Region Resorts & 5 Star Hotels
Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Mediterranean Region to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Mediterranean Region 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Mediterranean Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.