Explore top 2026 5 Star Hotels in Mediterranean Region

Name: Wellington Hotel & Spa Madrid
Price range: $714 total

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Top Mediterranean Region 5 Star hotels

Grand Hyatt Athens

115, Syngrou Avenue Athens Attica

Fully refundableReserve now, pay when you stay

$204 nightly

$250 total

Sep 21 - Sep 22

Total with taxes and fees

A full-service spa, an indoor pool, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

8.6/10 Excellent! (1,474 reviews)

"The hotel is nice and generally the staff are nice too. The check in time at the reception will be approximately 1 hour EVERYDAY! The management know this but they don’t care. They have 4 station at the reception but only 1 or 2 attendant are present. The glasses at the pool bar are so oiled and ..."

Reviewed on Sep 7, 2026

Corinthia Lisbon

Avenida Columbano Bordalo Pinheiro, 105 Lisbon

Fully refundableReserve now, pay when you stay

$282 nightly

$308 total

Sep 10 - Sep 11

Total with taxes and fees

A full-service spa, 3 restaurants, and an indoor pool are all featured at this luxury hotel. Families will appreciate the children's pool, kid-friendly dining, ...

Grand Hyatt Barcelona

Plaza de Pio XII, 4 Barcelona

Fully refundableReserve now, pay when you stay

$236 nightly

$291 total

Sep 20 - Sep 21

Total with taxes and fees

A full-service spa, 2 restaurants, and a hot tub are all featured at this luxury hotel. Enjoy the gym and perks like free WiFi. Enjoy the seasonal outdoor pool ...

9.2/10 Wonderful! (1,602 reviews)

"Very nice hotel but check-in was terrible, waited an hour in total! The room needed improvements. The mattresses weren’t very comfortable. The water machine would go off in the middle of the night & wake us up. The extra bed in the triple room was on wheels so moved around & had no head board-just ..."

Reviewed on Sep 5, 2026

Nobu Hotel Barcelona

Avenida de Roma 2-4 Barcelona Barcelona

Fully refundableReserve now, pay when you stay

$328 nightly

$392 total

Oct 4 - Oct 5

Total with taxes and fees

A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Relax with a drink at one of the 2 bars/lounges and get perks like free WiFi. ...

W Barcelona

Plaça Rosa dels Vents, 1 Barcelona

Fully refundableReserve now, pay when you stay

$350 nightly

$416 total

Oct 4 - Oct 5

Total with taxes and fees

A full-service spa, 4 restaurants, and an indoor pool are all featured at this smoke-free hotel. Enjoy beachfront dining and relax with sun loungers and beach ...

8.8/10 Excellent! (1,010 reviews)

"Location and facilities are fantastic!"

Reviewed on Sep 7, 2026

Sofitel Athens Airport

Athens International Airport Spata-Artemida Attiki

Fully refundableReserve now, pay when you stay

$459 nightly

$539 total

Oct 8 - Oct 9

Total with taxes and fees

A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...

9.4/10 Exceptional! (2,671 reviews)

"Easy quick check in and out. Walking distance to the Athens airport"

Reviewed on Sep 7, 2026

InterContinental Barcelona by IHG

Avenida Ruis I Taulet 1-3 Barcelona

Fully refundable

$232 nightly

$286 total

Sep 13 - Sep 14

Total with taxes and fees

A full-service spa, 2 restaurants, and a gym are all featured at this luxury hotel. Traveling on business? Take advantage of the business center and free WiFi ...

Hotel Real Palacio

Rua Tomas Ribeiro 115 Lisbon

$158 nightly

$177 total

Sep 9 - Sep 10

Total with taxes and fees

The hotel's gym, hot tub, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the 24-hour business center and free ...

8.6/10 Excellent! (1,002 reviews)

"This is a 5-star hotel all around! Even as an American with high standards this hotel is just amazing. The interior or lobby and everything is wow. And rooms are very clean and awesome service. Ah and also the health spa with whirlpool and sauna and steam room. The best after a long day of Touring. ..."

Reviewed on Aug 21, 2026

Divani Palace Acropolis

19 25 Parthenonos St Athens Attiki

Fully refundable

$257 nightly

$310 total

Oct 5 - Oct 6

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a gym. Families will appreciate the onsite laundry facilities, kid-friendly dining, and in-room ...

9/10 Wonderful! (1,031 reviews)

"Someone stole my sunglasses at the property (either at the bag hold or in the room) that were extremely rare and expensive, staff did nothing to solve the problem. Completely unacceptable. In addition to that, the room had someone else’s hair all over it and dirt on the sheets when I checked in. ..."

Reviewed on Sep 7, 2026

Wellington Hotel & Spa Madrid

Velazquez 8 Madrid Madrid

Fully refundableReserve now, pay when you stay

$649 nightly

$714 total

Sep 29 - Sep 30

Total with taxes and fees

A full-service spa, 3 restaurants, and a hot tub are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities and in-room childcare. ...

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Five Star Hotels in Mediterranean Region

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Mediterranean Region to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Mediterranean Region 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Mediterranean Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.