Explore top 2026 4 Star Hotels in Santa Cruz

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Top Santa Cruz 4 Star hotels

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
$122 nightly
The price is $122 total per night from Apr 10 to Apr 11
$122 total
Apr 10 - Apr 11
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. There's fun for all ages with a children's pool and a waterslide, ...
9/10 Wonderful! (420 reviews)
Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options.

Reviewed on Feb 5, 2026

Opens in a new windowCamino Real Hotel
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4 out of 5
Av. San Martin, Calle 9 Este Santa Cruz
$89 nightly
The price is $89 total per night from Mar 13 to Mar 14
$89 total
Mar 13 - Mar 14
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Enjoy the gym and free perks like buffet breakfast and free self parking. There's a sauna ...
Opens in a new windowTRYP by Wyndham Santa Cruz
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E Santa Cruz
$74 nightly
The price is $74 total per night from Mar 15 to Mar 16
$74 total
Mar 15 - Mar 16
This hotel features a restaurant, a gym, and a bar/lounge. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...
9.2/10 Wonderful! (264 reviews)
The room was clean, breakfast was standard for South America and the staff were great. However, the bed was advertised as a queen and it was a double bed. The rolling desk chair on the tile floor is a serious accident waiting to happen. I enjoyed the views from the rooftop buffet.

Reviewed on Mar 7, 2026

Opens in a new windowHampton by Hilton Santa Cruz/Equipetrol, Bolivia
Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

4.5 out of 5
5to anillo Avenida La Salle # 4500 Santa Cruz
Fully refundableReserve now, pay when you stay
$126 nightly
The price is $126 total per night from Mar 26 to Mar 27
$126 total
Mar 26 - Mar 27
A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the free WiFi in public ...
9.2/10 Wonderful! (86 reviews)
Great room, spacious, quiet and the shower was great

Reviewed on Mar 2, 2026

Opens in a new windowSwissôtel Santa Cruz De La Sierra
Hotel Maywa

Hotel Maywa

4 out of 5
2do anillo av.santacruz #1007 Santa Cruz Santa Cruz Department
This hotel features a 24-hour gym and a rooftop terrace. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, and airport ...
9.2/10 Wonderful! (10 reviews)
The structure and service was fantastic

Reviewed on Sep 17, 2025

Opens in a new windowHotel Maywa
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the children's pool and barbecue grills. Enjoy the gym and perks ...
Opens in a new windowBuganvillas Hotel Suites & Spa
Royal Lodge Hotel

Royal Lodge Hotel

4.5 out of 5
Avenida San Martin 200 Santa Cruz
This hotel features an outdoor pool, a gym, and a restaurant. There's no skimping on freebies - guests receive free full breakfast, free WiFi, and free self ...
Opens in a new windowRoyal Lodge Hotel
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4 Star Hotels Santa Cruz

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Santa Cruz 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Santa Cruz will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Santa Cruz, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Santa Cruz hotel reviews by fellow wanderers