Explore top 2025 4 Star Hotels in Grafton

Name: Overlook Main St. in this 2 Bedroom Owners Suite!
Address: Saint Charles
Rating: 9.4

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Top Grafton 4 Star hotels

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road, St. Louis, MO

$118 nightly

$138 total

Oct 31 - Nov 1

Total with taxes and fees

This hotel features an indoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, laundry service, and ...

8.4/10 Very Good! (1,017 reviews)

Upscale nice hotel

"The hotel room was clean, and the staff were friendly and courteous. We enjoyed a delicious meal at the hotel restaurant, and although our stay was only one night, we plan to stay longer next time."

Reviewed on Oct 7, 2025

DoubleTree by Hilton St. Louis Airport

4505 Woodson Road, St. Louis, MO

Fully refundableReserve now, pay when you stay

$110 nightly

$129 total

Oct 11 - Oct 12

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Bring the family and enjoy the arcade/game room and kid-friendly dining. There's no skimping ...

7.8/10 Good! (825 reviews)

"Friendly, quiet and clean"

Reviewed on Sep 15, 2025

Ameristar Casino Resort and Spa

1 Ameristar Blvd, St. Charles, MO

Fully refundableReserve now, pay when you stay

$192 nightly

$224 total

Oct 19 - Oct 20

Total with taxes and fees

This luxury hotel features a casino, a full-service spa, and 6 restaurants. Enjoy the 2 hot tubs and 24-hour gym, and unwind with a drink at the poolside ...

8.2/10 Very Good! (1,003 reviews)

"Not a single negative. Clean , not over priced, Great staff and employees"

Reviewed on Sep 30, 2025

Marriott St. Louis Airport

10700 Pear Tree Lane, St. Louis, MO

Fully refundableReserve now, pay when you stay

$128 nightly

$152 total

Oct 24 - Oct 25

Total with taxes and fees

This hotel features an indoor pool, a gym, and a restaurant. Traveling on business? Take advantage of the business center, express check-in, and free airport ...

7.8/10 Good! (1,001 reviews)

"Friendly and professional staff. Good property."

Reviewed on Sep 29, 2025

DoubleTree by Hilton St. Louis - Westport

1973 Craigshire Rd, Maryland Heights, MO

Fully refundableReserve now, pay when you stay

$127 nightly

$147 total

Oct 16 - Oct 17

Total with taxes and fees

This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

8/10 Very Good! (1,002 reviews)

"The property was very nice however, my main kudos goes to the staff. There was a plumbing issue. They got me to another room and will refund a one night‘s stay"

Reviewed on Sep 29, 2025

Overlook Main St. in this 2 Bedroom Owners Suite!

Saint Charles

This apartment features laundry facilities.

9.4/10 Exceptional! (33 reviews)

"Easy to find, super easy check in, heads up: lots of stairs at this property! This location is at the very north end of Main Street located directly across from a night club, directly above a bar with live music, and 1 block down from a popular honky tonk so it is very noisy at night until about ..."

Reviewed on Jul 29, 2025

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Beall Mansion An Elegant Bed & Breakfast Inn

407 E. 12th St., Alton, IL

This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the 4 hot tubs and free continental breakfast each ...

Excellent bed and breakfast!

"Wonderful stay! This home is beautiful. Our hosts Sandy and Jim were gracious and it was a pleasure to be with them for the evening. Highly recommended!"

Reviewed on Oct 21, 2024

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Grafton

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Grafton 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Grafton will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Grafton, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.