Explore 5 Luxury Hotels in Santee

Name: Econo Lodge
Price range: $67 total
Rating: 6.2

Best Luxury Hotels in Santee

Comfort Inn & Suites Santee

221 Britain St, Santee, SC

Fully refundableReserve now, pay when you stay

$103 nightly

$114 total

Aug 10 - Aug 11

Total includes taxes and fees

This hotel features a gym and a seasonal outdoor pool. There's no skimping on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. ...

7.8/10 Good! (1,009 reviews)

"It was ok good enough for the night. Breakfast is good"

Reviewed on Jul 20, 2025

Baymont by Wyndham Santee

249 Britain Street, Santee, SC

Fully refundableReserve now, pay when you stay

$75 nightly

$83 total

Jul 27 - Jul 28

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...

7.8/10 Good! (1,326 reviews)

"Every one was friendly and the whole place was spotless."

Reviewed on Jul 22, 2025

Red Roof Inn Santee

9091 Old Hwy 6, Santee, SC

Fully refundableReserve now, pay when you stay

$65 nightly

$72 total

Aug 3 - Aug 4

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of ...

6.4/10 (620 reviews)

"Great"

Reviewed on Jun 20, 2025

Ramada by Wyndham Santee I-95

123 Mall Street, Santee, SC

Fully refundableReserve now, pay when you stay

$82 nightly

$92 total

Aug 4 - Aug 5

Total includes taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

6.2/10 (531 reviews)

"Nice clean friendly"

Reviewed on Jul 11, 2025

Econo Lodge

9112 Old 6 Highway, Santee, SC

Fully refundableReserve now, pay when you stay

$60 nightly

$67 total

Aug 10 - Aug 11

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. A garden, luggage storage, and barbecue grills are also on offer.

6.2/10 (308 reviews)

"Clean room. No issues with late check"

Reviewed on Jun 5, 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santee Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Santee luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Santee to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Santee will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Santee, and plan your next opulent escape.

Santee hotels essential information

Accommodation	288 hotels
Lowest Price	$67
Highest Price	$114
Popular hotels	Red Roof Inn Santee, Comfort Inn & Suites Santee, Baymont by Wyndham Santee, Ramada by Wyndham Santee I-95, Econo Lodge