Explore 24 Luxury Hotels in Durham

Name: SureStay Plus Hotel by Best Western Durham Medical Center
Price range: $75 total

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Best Luxury Hotels in Durham

Washington Duke Inn & Golf Club

3001 Cameron Blvd Durham NC

Fully refundableReserve now, pay when you stay

$229 nightly

$260 total

Oct 11 - Oct 12

Total with taxes and fees

A golf course, 3 restaurants, and an indoor pool are all featured at this boutique hotel. Family-friendly amenities include an arcade/game room and in-room childcare. ...

9.4/10 Exceptional! (1,001 reviews)

"Great experience, pool /hottube could use updated. Breakfast had small Buffet, others have larger."

Reviewed on Sep 8, 2026

JB Duke Hotel

230 Science Drive Durham NC

Fully refundableReserve now, pay when you stay

$200 nightly

$227 total

Sep 21 - Sep 22

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. A business center, ...

9.4/10 Exceptional! (702 reviews)

"Beautiful place"

Reviewed on Sep 7, 2026

DoubleTree Raleigh Durham Airport at Research Triangle Park

4810 Page Creek Ln Durham NC

Fully refundableReserve now, pay when you stay

$114 nightly

$129 total

Sep 18 - Sep 19

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9/10 Wonderful! (1,000 reviews)

"The staff were wonderful and the rooms were clean. I can’t believe how quiet the room was, as that’s a rarity when staying at hotels now. The staff checked up on us via text throughout our stay to make sure everything was going well."

Reviewed on Sep 7, 2026

La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

4414 Durham Chapel Hill Blvd Durham NC

Fully refundableReserve now, pay when you stay

$84 nightly

$95 total

Sep 13 - Sep 14

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...

8.6/10 Excellent! (1,975 reviews)

"Very clean and staff are respectful thank you. I will choose this hotel gain in case I visit again."

Reviewed on Sep 8, 2026

Red Roof Inn Durham - Duke Univ Medical Center

1915 N Pointe Drive Durham NC

Fully refundableReserve now, pay when you stay

$64 nightly

$73 total

Oct 11 - Oct 12

Total with taxes and fees

Free self parking is available and the hotel's front desk is staffed around-the-clock. WiFi in public areas is free. A safe deposit box is also provided.

6.8/10 (1,002 reviews)

"Bugs, dirty sheets"

Reviewed on Sep 9, 2026

Comfort Inn University Durham - Chapel Hill

3508 Mt Moriah Rd Durham NC

Fully refundable

$87 nightly

$99 total

Oct 1 - Oct 2

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free ...

Fairfield Inn & Suites by Marriott Durham Southpoint

7807 Leonardo Dr Durham NC

Fully refundableReserve now, pay when you stay

$114 nightly

$129 total

Sep 23 - Sep 24

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

SureStay Plus Hotel by Best Western Durham Medical Center

3710 Hillsborough Rd Durham NC

Fully refundableReserve now, pay when you stay

$66 nightly

$75 total

Sep 16 - Sep 17

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the business ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Durham

2 Mi to Duke & 3 Mi to Downtown: Durham Townhome

Durham NC

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Durham Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Durham luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Durham to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Durham will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Durham, and plan your next opulent escape.

Durham hotels essential information

Accommodation	815 hotels
Lowest Price	$73
Highest Price	$260
Popular hotels	Washington Duke Inn & Golf Club, Red Roof Inn Durham - Duke Univ Medical Center, DoubleTree Raleigh Durham Airport at Research Triangle Park, JB Duke Hotel, La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill, Comfort Inn University Durham - Chapel Hill, Fairfield Inn & Suites by Marriott Durham Southpoint, SureStay Plus Hotel by Best Western Durham Medical Center