Explore 24 Luxury Hotels in Durham

Name: Comfort Inn University Durham - Chapel Hill
Price range: $96 total

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Best Luxury Hotels in Durham

DoubleTree Raleigh Durham Airport at Research Triangle Park

4810 Page Creek Ln Durham NC

Fully refundableReserve now, pay when you stay

$109 nightly

$123 total

Oct 31 - Nov 1

Total with taxes and fees

This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...

9/10 Wonderful! (1,002 reviews)

"Room was clean and staff was great and helpful. Warm cookie at check-in was a nice touch."

Reviewed on Oct 11, 2026

La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

4414 Durham Chapel Hill Blvd Durham NC

Fully refundableReserve now, pay when you stay

$86 nightly

$98 total

Oct 18 - Oct 19

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...

8.6/10 Excellent! (1,986 reviews)

"Walls are very thin. We were kept up all night with our neighbors talking from 7pm to 6 am. Recent car break ins that we didn’t know about until after we booked a non-refundable room and breakfast was bad. I’d choose somewhere else next time."

Reviewed on Oct 11, 2026

Fairfield Inn & Suites by Marriott Durham Southpoint

7807 Leonardo Dr Durham NC

Fully refundableReserve now, pay when you stay

$114 nightly

$129 total

Oct 25 - Oct 26

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...

8.4/10 Very Good! (791 reviews)

"Everything inside the hotel was good for the purpose of spending the night before a longer road trip. Clean room, shared spaces and kind staff. Only reason for a poor rating is safety. There were multiple cars that were broken into over the night of our stay and multiple patrol cars taking reports ..."

Reviewed on Oct 1, 2026

SureStay Plus Hotel by Best Western Durham Medical Center

3710 Hillsborough Rd Durham NC

Fully refundableReserve now, pay when you stay

$66 nightly

$75 total

Oct 18 - Oct 19

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free full breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of the business ...

5.6/10 (1,003 reviews)

"The property isn't very appealing. Yes, there are amenities, but the floors are lumpy, the shower in the bathroom needs to be resurfaced, the room is not attractive. The walls were painted blue, had 1 picture hanging. I had the sign hanging on the doorknob requested housekeeping for a day and a half, ..."

Reviewed on Oct 9, 2026

Washington Duke Inn & Golf Club

3001 Cameron Blvd Durham NC

Fully refundableReserve now, pay when you stay

$240 nightly

$272 total

Oct 13 - Oct 14

Total with taxes and fees

A golf course, 3 restaurants, and an indoor pool are all featured at this boutique hotel. Family-friendly amenities include an arcade/game room and in-room childcare. ...

Red Roof Inn Durham - Duke Univ Medical Center

1915 N Pointe Drive Durham NC

Fully refundableReserve now, pay when you stay

$64 nightly

$73 total

Nov 1 - Nov 2

Total with taxes and fees

Free self parking is available and the hotel's front desk is staffed around-the-clock. WiFi in public areas is free. A safe deposit box is also provided.

JB Duke Hotel

230 Science Drive Durham NC

Fully refundableReserve now, pay when you stay

$199 nightly

$226 total

Oct 12 - Oct 13

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Guests will appreciate free perks like free self parking and WiFi in public areas. A business center, ...

Comfort Inn University Durham - Chapel Hill

3508 Mt Moriah Rd Durham NC

Fully refundable

$84 nightly

$96 total

Nov 8 - Nov 9

Total with taxes and fees

This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Free ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Durham

2 Mi to Duke & 3 Mi to Downtown: Durham Townhome

Durham NC

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Durham Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Durham luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Durham to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Durham will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Durham, and plan your next opulent escape.

Durham hotels essential information

Accommodation	778 hotels
Lowest Price	$73
Highest Price	$272
Popular hotels	Washington Duke Inn & Golf Club, Red Roof Inn Durham - Duke Univ Medical Center, DoubleTree Raleigh Durham Airport at Research Triangle Park, JB Duke Hotel, La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill, Comfort Inn University Durham - Chapel Hill, Fairfield Inn & Suites by Marriott Durham Southpoint, SureStay Plus Hotel by Best Western Durham Medical Center