Explore top 2026 5 Star Hotels in Mediterranean Region

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Top Mediterranean Region 5 Star hotels

Grand Hyatt Athens

Grand Hyatt Athens

5 out of 5
115, Syngrou Avenue Athens Attica
Fully refundableReserve now, pay when you stay
$86 nightly
The price is $103 total per night from Feb 5 to Feb 6
$103 total
Feb 5 - Feb 6
Total with taxes and fees
A full-service spa, an indoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, free ...
8.6/10 Excellent! (1,035 reviews)
Everything was very good

Reviewed on Jan 16, 2026

Opens in a new windowGrand Hyatt Athens
Lamaro Hotel

Lamaro Hotel

5 out of 5
Avenida Catedral, 7 Barcelona
Fully refundable
$259 nightly
The price is $304 total per night from Feb 8 to Feb 9
$304 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 2 conference rooms, free WiFi in public areas, ...
9.4/10 Exceptional! (1,846 reviews)
Everything was perfect! Raining days, but wonderful place and pretty nice staff. Thank you guys

Reviewed on Jan 19, 2026

Opens in a new windowLamaro Hotel
Hyatt Regency Barcelona Tower

Hyatt Regency Barcelona Tower

5 out of 5
Gran Via 144 L'Hospitalet de Llobregat
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $158 total per night from Feb 8 to Feb 9
$158 total
Feb 8 - Feb 9
Total with taxes and fees
This luxury hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Enjoy the seasonal outdoor pool and perks like free WiFi. Self parking, a business ...
8.8/10 Excellent! (1,017 reviews)
Our room was spotless, panoramic view, courteous staff, live entertainment

Reviewed on Jan 15, 2026

Opens in a new windowHyatt Regency Barcelona Tower
The Palace, a Luxury Collection Hotel, Madrid

The Palace, a Luxury Collection Hotel, Madrid

5 out of 5
Plaza de las Cortes, 7 Madrid Madrid
Fully refundableReserve now, pay when you stay
$383 nightly
The price is $421 total per night from Jan 30 to Jan 31
$421 total
Jan 30 - Jan 31
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
9/10 Wonderful! (1,004 reviews)
Very good.

Reviewed on Jan 5, 2026

Opens in a new windowThe Palace, a Luxury Collection Hotel, Madrid
Barceló Torre de Madrid

Barceló Torre de Madrid

5 out of 5
Plaza de España, 18 Madrid
Fully refundable
$203 nightly
The price is $223 total per night from Feb 8 to Feb 9
$223 total
Feb 8 - Feb 9
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, ...
9.4/10 Exceptional! (2,312 reviews)
Great

Reviewed on Jan 18, 2026

Opens in a new windowBarceló Torre de Madrid
Only YOU Hotel Sevilla

Only YOU Hotel Sevilla

5 out of 5
Avenida De Kansas City No.7 Seville Seville
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $171 total per night from Feb 3 to Feb 4
$171 total
Feb 3 - Feb 4
Total with taxes and fees
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
9.6/10 Exceptional! (611 reviews)
Great location, clean, & staff

Reviewed on Jan 19, 2026

Opens in a new windowOnly YOU Hotel Sevilla
Sofitel Athens Airport

Sofitel Athens Airport

5 out of 5
Athens International Airport Spata-Artemida Attiki
Fully refundableReserve now, pay when you stay
$256 nightly
The price is $295 total per night from Feb 10 to Feb 11
$295 total
Feb 10 - Feb 11
Total with taxes and fees
A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
9.4/10 Exceptional! (2,615 reviews)
The price paid for the stay really do reflect the excellent accommodation condition and services they provide. Room air conditioning sound level is excellent compared to other big building hotels I've stayed in before. Facilities such as toilet is second to none. Swimming/dipping pool and sauna is ...

Reviewed on Jan 16, 2026

Opens in a new windowSofitel Athens Airport
Nobu Hotel Barcelona

Nobu Hotel Barcelona

5 out of 5
Avenida de Roma 2-4 Barcelona Barcelona
Fully refundableReserve now, pay when you stay
$233 nightly
The price is $276 total per night from Feb 18 to Feb 19
$276 total
Feb 18 - Feb 19
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Relax with a drink at one of the 2 bars/lounges and get perks like free WiFi. ...
8.8/10 Excellent! (1,208 reviews)
Property is beautiful and the staff was exceptionally friendly and service oriented.

Reviewed on Jan 18, 2026

Opens in a new windowNobu Hotel Barcelona
Majestic Hotel & Spa Barcelona

Majestic Hotel & Spa Barcelona

5 out of 5
Passeig De Gracia, 68 Barcelona
Fully refundableReserve now, pay when you stay
$312 nightly
The price is $363 total per night from Feb 9 to Feb 10
$363 total
Feb 9 - Feb 10
Total with taxes and fees
A full-service spa, a gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, free WiFi in ...
9.2/10 Wonderful! (1,001 reviews)
Room was very clean, staff is amazing. The location is the best part of all. Just don't do laundry their lol

Reviewed on Jan 15, 2026

Opens in a new windowMajestic Hotel & Spa Barcelona
Eurostars Grand Marina

Eurostars Grand Marina

5 out of 5
Moll De Barcelona S/n Barcelona
$157 nightly
The price is $192 total per night from Jan 25 to Jan 26
$192 total
Jan 25 - Jan 26
Total with taxes and fees
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and airport ...
8.8/10 Excellent! (1,194 reviews)
Staff were great, room was great, very convenient for the cruise port, shuttle bus stop only a couple of hundred yards away

Reviewed on Jan 16, 2026

Opens in a new windowEurostars Grand Marina
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Mediterranean Region Resorts & 5 Star Hotels

Looking for your own little slice of heaven during your next trip? Check out all the best 5-star hotels in Mediterranean Region to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the 5-star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Mediterranean Region 5-star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5-star hotels in Mediterranean Region before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Mediterranean Region hotel reviews by fellow wanderers