Explore top 2026 5 Star Hotels in Medical Center District

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Top Medical Center District 5 Star hotels

Thompson San Antonio - Riverwalk, by Hyatt

115 Lexington Avenue San Antonio TX

Fully refundableReserve now, pay when you stay

$206 nightly

$244 total

Feb 8 - Feb 9

Total with taxes and fees

A full-service spa, an outdoor pool, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the free WiFi in public ...

9/10 Wonderful! (940 reviews)

Excellent check in and out.

Reviewed on Jan 4, 2026

The Luxury Suites at Arrive Eilan

17803 La Cantera Terrace San Antonio TX

An outdoor pool is available at this apartment. Take advantage of the free self parking.

Very nice. Easy and Clean

Reviewed on Jul 11, 2022

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.