Explore 83 Luxury Hotels in South Carolina Midlands

Name: Sheraton Columbia Downtown Hotel
Price range: $132 total

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Best Luxury Hotels in South Carolina Midlands

Carriage House Inn

139 Laurens Street, Northwest Aiken SC

Fully refundable

$179 nightly

$201 total

Nov 8 - Nov 9

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry ...

9.6/10 Exceptional! (600 reviews)

"Staff were incredibly kind and Inn was beautiful on the inside. If we find ourselves back in Aiken we will happily be staying again! We loved our stay!"

Reviewed on Oct 30, 2026

Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd Orangeburg SC

Fully refundableReserve now, pay when you stay

$65 nightly

$72 total

Nov 8 - Nov 9

Total with taxes and fees

Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.

8.2/10 Very Good! (1,000 reviews)

"Room was clean, bed was comfy, staff pleasant and friendly. Parking safe and large spots. My only concern was my husband noted the smoke detector was not in working order. There was a bracket and wire, but no smoke detector."

Reviewed on Nov 1, 2026

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

1047 Riverview Rd Rock Hill SC

Fully refundableReserve now, pay when you stay

$61 nightly

$69 total

Dec 1 - Dec 2

Total with taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling for business? Take advantage of ...

6.8/10 (1,000 reviews)

"Bedbugs!!! Beware. We stayed in room 105 where we were bitten by bed bids from top to bottom - my face is all swollen from multiple bed bug bites, hands ,fingers, legs, back - everything is itchy."

Reviewed on Nov 2, 2026

The Ballantyne, A Luxury Collection Hotel, Charlotte

10000 Ballantyne Commons Pkwy Charlotte NC

Fully refundableReserve now, pay when you stay

$329 nightly

$382 total

Nov 23 - Nov 24

Total with taxes and fees

A full-service spa, 2 restaurants, and an indoor pool are all featured at this smoke-free hotel. Families will appreciate the playground and complimentary bicycles. ...

The Willcox

100 Colleton Avenue SW Aiken SC

$321 nightly

$359 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

The Mantissa Hotel

130 East Carolina Ave Hartsville SC

$180 nightly

$202 total

Nov 10 - Nov 11

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

Inn on the Square, an Ascend Collection Hotel

104 Court Avenue East Greenwood SC

Fully refundable

$103 nightly

$114 total

Nov 29 - Nov 30

Total with taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference center. ...

Sheraton Columbia Downtown Hotel

1400 Main St Columbia SC

Fully refundableReserve now, pay when you stay

$118 nightly

$132 total

Nov 8 - Nov 9

Total with taxes and fees

This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in South Carolina Midlands

Upscale Home w/ Poker Room < 1 Mi to Golf!

Aiken SC

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10/10 Exceptional! (1 review)

South Carolina Midlands Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Carolina Midlands luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South Carolina Midlands to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South Carolina Midlands will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Carolina Midlands, and plan your next opulent escape.

South Carolina Midlands hotels essential information

Accommodation	3,402 hotels
Lowest Price	$69
Highest Price	$382
Popular hotels	The Ballantyne, A Luxury Collection Hotel, Charlotte, The Willcox, The Mantissa Hotel, Travelodge by Wyndham Orangeburg, Carriage House Inn, Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area, Inn on the Square, an Ascend Collection Hotel, Sheraton Columbia Downtown Hotel