Explore 83 Luxury Hotels in South Carolina Midlands

Name: Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
Price range: $74 total
Rating: 7

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Best Luxury Hotels in South Carolina Midlands

The Willcox

100 Colleton Avenue SW, Aiken, SC

Fully refundableReserve now, pay when you stay

$286 nightly

$321 total

Jul 6 - Jul 7

Total includes taxes and fees

This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...

9.6/10 Exceptional! (132 reviews)

"Love the room, attention to detail, great restaurant!"

Reviewed on May 12, 2025

Carriage House Inn

139 Laurens Street, Northwest , Aiken, SC

Fully refundableReserve now, pay when you stay

$200 nightly

$224 total

Jul 4 - Jul 5

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free breakfast, free WiFi, and free self parking. Business travelers can take advantage of the laundry ...

9.4/10 Exceptional! (435 reviews)

"Excellent stay, would definitely stay here when in Aiken."

Reviewed on Jun 20, 2025

The Ballantyne, A Luxury Collection Hotel, Charlotte

10000 Ballantyne Commons Pkwy, Charlotte, NC

Fully refundableReserve now, pay when you stay

$243 nightly

$280 total

Jul 6 - Jul 7

Total includes taxes and fees

A full-service spa, 2 indoor pools, and A 24-hour gym are all featured at this luxury hotel. Families will appreciate the playground and complimentary bicycles. ...

9.2/10 Wonderful! (958 reviews)

"Check in quick and got our room early. Beautiful hotel! We spent the afternoon in the pool. Walking distance to the Amp at Ballantyne where we saw a great concert. Very happy with the whole resort."

Reviewed on Jun 27, 2025

Inn on the Square, Ascend Hotel Collection

104 Court Avenue East, Greenwood, SC

$118 nightly

$131 total

Jul 20 - Jul 21

Total includes taxes and fees

A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas and onsite conference center. ...

9.2/10 Wonderful! (671 reviews)

"Look good. Clean this. Good surrounding area. Will stay there again. Great location will advise other people to come to the hotel. Staff was very professional. Great location to activities stores shopping areas, very family oriented. Would like to visit there again. Great Breakfast"

Reviewed on Jun 23, 2025

The Mantissa Hotel

130 East Carolina Ave, Hartsville, SC

Fully refundableReserve now, pay when you stay

$170 nightly

$191 total

Aug 1 - Aug 2

Total includes taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Enjoy the a rooftop terrace and free perks like on-the-go breakfast and free self parking. A business ...

9/10 Wonderful! (241 reviews)

Very nice

"The hotel is beautiful and the staff is friendly... the pull out bed was the most comfortable one we've ever had. The area is nice with the local small business and downtown feel. The only complaint is that there is a pool advertised and the pool they are referring to is the community Y pool across ..."

Reviewed on Jun 29, 2025

Sheraton Columbia Downtown Hotel

1400 Main St, Columbia, SC

Fully refundableReserve now, pay when you stay

$112 nightly

$125 total

Jul 13 - Jul 14

Total includes taxes and fees

This hotel features 2 bars/lounges and a 24-hour gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. ...

8.2/10 Very Good! (1,004 reviews)

"Front desk was extremely nice and helpful"

Reviewed on Jun 29, 2025

Travelodge by Wyndham Orangeburg

3620 Saint Matthews Rd, Orangeburg, SC

Fully refundableReserve now, pay when you stay

$80 nightly

$89 total

Jul 6 - Jul 7

Total includes taxes and fees

Free self parking is available and the motel's front desk is staffed around-the-clock. WiFi in public areas is free. Express check-out is also provided.

8/10 Very Good! (983 reviews)

"Everything were good"

Reviewed on Jul 2, 2025

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

1047 Riverview Rd, Rock Hill, SC

Fully refundableReserve now, pay when you stay

$67 nightly

$74 total

Jul 13 - Jul 14

Total includes taxes and fees

This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Traveling on business? Take advantage of ...

7/10 Good! (1,003 reviews)

"Hotel staff was very friendly and accommodating. The hotel room and bathroom was very clean. Hotel lobby as well as check-in area needs an update. Bed was very uncomfortable, but very clean location of hotel was very close to all local restaurants as well as softball and baseball fields."

Reviewed on Jun 29, 2025

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South Carolina Midlands Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the South Carolina Midlands luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in South Carolina Midlands to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in South Carolina Midlands will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in South Carolina Midlands, and plan your next opulent escape.

South Carolina Midlands hotels essential information

Accommodation	2,933 hotels
Lowest Price	$74
Highest Price	$321
Popular hotels	The Ballantyne, A Luxury Collection Hotel, Charlotte, The Willcox, The Mantissa Hotel, Travelodge by Wyndham Orangeburg, Carriage House Inn, Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area, Inn on the Square, Ascend Hotel Collection, Sheraton Columbia Downtown Hotel