Explore 20 Luxury Hotels in Santa Cruz

Name: EME Catedral Mercer Hotel
Price range: $247 total
Rating: 8.8

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Best Luxury Hotels in Santa Cruz

Hotel Boutique Casa del Poeta Sevilla

Don Carlos Alonso Chaparro 3 Seville Seville

Fully refundableReserve now, pay when you stay

$247 nightly

$271 total

Mar 15 - Mar 16

Total with taxes and fees

A bar/lounge and a 24-hour front desk are featured at this hotel, along with valet parking. WiFi in public areas is free. A coffee shop, a terrace, and a snack ...

9.8/10 Exceptional! (896 reviews)

Everything was perfect there.

Reviewed on Mar 2, 2026

Hotel Fernando III

San Jose 21 Seville Seville

Fully refundableReserve now, pay when you stay

$213 nightly

$235 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

9.6/10 Exceptional! (1,512 reviews)

Fantastic location. Very clean and modern rooms. Breakfast buffet is very complete with excellent choices.

Reviewed on Mar 11, 2026

Hotel Amadeus Sevilla

Calle Farnesio 6 Seville Seville

Fully refundableReserve now, pay when you stay

$209 nightly

$230 total

Mar 22 - Mar 23

Total with taxes and fees

This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. Self parking, a coffee shop, and ...

9.6/10 Exceptional! (1,155 reviews)

Very walkable to most of the attractions. Good breakfast.

Reviewed on Mar 11, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

San Fernando 2 Seville Seville

Fully refundableReserve now, pay when you stay

$695 nightly

$764 total

Apr 6 - Apr 7

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

9.4/10 Exceptional! (1,001 reviews)

Staff

Reviewed on Feb 27, 2026

El Rey Moro Hotel Boutique

Reinoso, 8 Seville Seville

Fully refundableReserve now, pay when you stay

$247 nightly

$271 total

Mar 16 - Mar 17

Total with taxes and fees

This hotel features a restaurant, a rooftop terrace, and a bar/lounge. Enjoy the hot tub and perks like free WiFi. A terrace, a snack bar/deli, and a library ...

9.4/10 Exceptional! (910 reviews)

Excellent place to stay. Very close to Real Alcazar, La Catedral de Sevilla and La Giralda. Many restaurants and bars to go out at any time during the day. Very safe to walk around till late at night. Very friendly staff, I'll recommend it 100%

Reviewed on Mar 10, 2026

Hotel Boutique Palacio Pinello

Calle Segovia, 1 Seville Seville

Fully refundableReserve now, pay when you stay

$181 nightly

$200 total

Mar 15 - Mar 16

Total with taxes and fees

This hotel features a rooftop terrace and a bar/lounge. WiFi in public areas is free. A business center, a terrace, and a snack bar/deli are also on offer.

9.4/10 Exceptional! (696 reviews)

Central location great walking around the area.

Reviewed on Mar 11, 2026

Las Casas de la Judería, Sevilla Historic City Center

Calle Santa Maria La Blanca 5 Seville Seville

Fully refundableReserve now, pay when you stay

$392 nightly

$431 total

Mar 28 - Mar 29

Total with taxes and fees

This hotel features a full-service spa and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, ...

9.2/10 Wonderful! (1,023 reviews)

Spa cost too much to use

Reviewed on Mar 12, 2026

EME Catedral Mercer Hotel

Calle Alemanes 27 Seville Seville

Fully refundableReserve now, pay when you stay

$224 nightly

$247 total

Mar 24 - Mar 25

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the gym and perks like free WiFi. Enjoy the a rooftop ...

8.8/10 Excellent! (1,001 reviews)

The location is superb right in the heart of Seville. The reception staff were a total delight, so helpful with directions and bookings. I would definitely stay here again in stunning Seville!

Reviewed on Mar 11, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Santa Cruz

Hotel Boutique Palacio Pinello

Calle Segovia, 1 Seville Seville

$181 nightly

$200 total

Mar 15 - Mar 16

Total with taxes and fees

9.4/10 Exceptional! (696 reviews)

5 star hotels in Santa Cruz

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

San Fernando 2 Seville Seville

$695 nightly

$764 total

Apr 6 - Apr 7

Total with taxes and fees

9.4/10 Exceptional! (1,001 reviews)

Santa Cruz Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Santa Cruz luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Santa Cruz to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Santa Cruz will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Santa Cruz, and plan your next opulent escape.

Santa Cruz hotels essential information

Accommodation	436 hotels
Lowest Price	$145
Highest Price	$764
Popular hotels	Hotel Alfonso XIII, a Luxury Collection Hotel, Seville, EME Catedral Mercer Hotel, El Rey Moro Hotel Boutique, Hotel Boutique Casa del Poeta Sevilla, Las Casas de la Judería, Sevilla Historic City Center, Hotel Fernando III, Hotel Amadeus Sevilla, Hotel Boutique Palacio Pinello

Popular Luxury Stays in Santa Cruz

Recent Santa Cruz Hotel Reviews By Fellow Wanderers

Hotel Doña Maria

5 out of 5

Posted 1 hour ago

Travelocity Verified Review

"Centrally located, helpful staff. Would stay here again. It was our anniversary and we had a wonderful view of the cathedral from our room. "

A verified traveler stayed at Hotel Doña Maria

Hotel Convento La Gloria

4 out of 5

Posted 3 days ago

Travelocity Verified Review

"✓ Great location for places of interest, clean X No window, no kettle, no mirror, no extractor fan in bathroom, drainage to shower was so slow, the floor flooded, very noisy from internal courtyard, fan in room was useless. No taxi access to the road meant long walk with luggage. Although there was a cafe attached to the hotel, that would happily give hot water for drinks it meant having to wait until it was open and then get fully dressed to go down 3 floors (and back!) get an early morning drink. Poor facilities. Outdated!"

A verified traveler stayed at Hotel Convento La Gloria