Explore 20 Luxury Hotels in Santa Cruz

Name: Hotel Boutique Palacio Pinello
Price range: $119 total

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Best Luxury Hotels in Santa Cruz

Hotel Amadeus Sevilla

Calle Farnesio 6 Seville Seville

Fully refundableReserve now, pay when you stay

$130 nightly

$143 total

Nov 15 - Nov 16

Total with taxes and fees

This hotel features a bar/lounge, a poolside bar, and an outdoor pool. Enjoy the a rooftop terrace and perks like free WiFi. A coffee shop, a terrace, and a ...

9.6/10 Exceptional! (1,301 reviews)

"Beautiful historic building in the heart of Barrio Santa Cruz. The music theme is well done throughout. Gorgeous decor with a modern touch. Room was spacious, clean, with all the modern appointments. For the location and modern charm you can’t beat this hotel."

Reviewed on Nov 3, 2026

El Rey Moro Hotel Boutique

Reinoso, 8 Seville Seville

Fully refundableReserve now, pay when you stay

$113 nightly

$125 total

Nov 22 - Nov 23

Total with taxes and fees

This hotel features a restaurant, a rooftop terrace, and a bar/lounge. Enjoy the hot tub and perks like free WiFi. A terrace, a snack bar/deli, and a library ...

9.4/10 Exceptional! (978 reviews)

"Last minute overnight booking following a flight reorganisation. Fantastically helpful staff organised a 4:45am taxi and the driver arrived just as we came down to reception and took our bags to the taxi. In heart of old town, just 5 minutes walk to the Cathedral, so great location."

Reviewed on Oct 30, 2026

Las Casas de la Judería, Sevilla Historic City Center

Calle Santa Maria La Blanca 5 Seville Seville

Fully refundableReserve now, pay when you stay

$105 nightly

$115 total

Dec 1 - Dec 2

Total with taxes and fees

This hotel features a full-service spa and a seasonal outdoor pool. Traveling on business? Take advantage of the free WiFi in public areas, laundry service, ...

9.2/10 Wonderful! (1,027 reviews)

"great location and everythikng else"

Reviewed on Nov 1, 2026

EME Catedral Mercer Hotel

Calle Alemanes 27 Seville Seville

Fully refundableReserve now, pay when you stay

$201 nightly

$221 total

Nov 29 - Nov 30

Total with taxes and fees

A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Enjoy the gym and perks like free WiFi. Enjoy the a rooftop ...

8.8/10 Excellent! (1,000 reviews)

"There is no shower booth. That’s the only not good one."

Reviewed on Oct 23, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

San Fernando 2 Seville Seville

$482 nightly

$530 total

Dec 2 - Dec 3

Total with taxes and fees

This luxury hotel includes 2 restaurants, an outdoor pool, and a 24-hour gym. Traveling on business? Take advantage of the free WiFi in public areas, laundry ...

Hotel Boutique Casa del Poeta Sevilla

Don Carlos Alonso Chaparro 3 Seville Seville

Fully refundableReserve now, pay when you stay

$249 nightly

$273 total

Nov 22 - Nov 23

Total with taxes and fees

A bar/lounge and a 24-hour front desk are featured at this hotel, along with valet parking. WiFi in public areas is free. A coffee shop, a terrace, and a snack ...

Hotel Fernando III

San Jose 21 Seville Seville

Fully refundableReserve now, pay when you stay

$118 nightly

$129 total

Nov 30 - Dec 1

Total with taxes and fees

This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet ...

Hotel Boutique Palacio Pinello

Calle Segovia, 1 Seville Seville

Fully refundableReserve now, pay when you stay

$108 nightly

$119 total

Dec 3 - Dec 4

Total with taxes and fees

This hotel features a 24-hour gym and a rooftop terrace. Relax with a drink at the bar/lounge and enjoy perks like free WiFi. A business center, a terrace, and ...

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More 4 star hotels in Santa Cruz

El Rey Moro Hotel Boutique

Reinoso, 8 Seville Seville

$113 nightly

$125 total

Nov 22 - Nov 23

Total with taxes and fees

9.4/10 Exceptional! (978 reviews)

5 star hotels in Santa Cruz

EME Catedral Mercer Hotel

Calle Alemanes 27 Seville Seville

$201 nightly

$221 total

Nov 29 - Nov 30

Total with taxes and fees

8.8/10 Excellent! (1,000 reviews)

Santa Cruz Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Santa Cruz luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Santa Cruz to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Santa Cruz will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Santa Cruz, and plan your next opulent escape.

Santa Cruz hotels essential information

Accommodation	411 hotels
Lowest Price	$103
Highest Price	$530
Popular hotels	Hotel Alfonso XIII, a Luxury Collection Hotel, Seville, EME Catedral Mercer Hotel, El Rey Moro Hotel Boutique, Hotel Boutique Casa del Poeta Sevilla, Las Casas de la Judería, Sevilla Historic City Center, Hotel Fernando III, Hotel Amadeus Sevilla, Hotel Boutique Palacio Pinello

Popular Luxury Stays in Santa Cruz

Recent Santa Cruz Hotel Reviews By Fellow Wanderers

Hotel Amadeus Sevilla

5 out of 5

Posted 2 hours ago

Travelocity Verified Review

A verified traveler stayed at Hotel Amadeus Sevilla

Hotel Convento La Gloria

5 out of 5

Posted 1 day ago

Travelocity Verified Review

"Everything was clean and comfortable, and the staff were always helpful. It is situated very near the Giralda, and the views from the roof-top terrace in the evening are marvellous. I usually had breakfast in the bar which is part of the complex, and that was a good experience. The hotel itself is rather quaint, the rooms are ranged round interior patios, so it's a bit like the long-vanished convent. The whole hotel is furnished with pictures, statues, furniture salvaged from closed convents. So it's not a modern anonymous international hotel, but I recommend it: I've stayed there twice and hope to visit again some day."

A verified traveler stayed at Hotel Convento La Gloria

Hotel Murillo

4 out of 5

Posted 3 days ago

Travelocity Verified Review

"The hotel was amazing. Beautiful and architecturally amazing. The location is perfect, near to all the attractions. The only challenge is getting there as you can't reach it by car. There is a 2 min walk to get the hotel and you have to bring your luggage by foot, but it is totally worth it. There is parking nearby so not a big problem. My only recommendation is that they hotel could make it easier by establishing a valet service."

A verified traveler stayed at Hotel Murillo

Hotel Boutique Corral del Rey by ALUZ Collection

5 out of 5

Posted 2 weeks ago

Travelocity Verified Review

"This hotel is located in walking distance of restaurants, bars and shopping. It is beautiful and the breakfast is wonderful with a continental breakfast and food you can order off the menu too. They do have elevators to the room. The rooms are beautiful and very clean. We were greeted by Patricia with a warm welcome and given information about our room, hotel and restaurants etc. When we had to leave early in the morning for the airport they prepared a “picnic” breakfast to take with us to eat. We loved this hotel and the friendly atmosphere and location. We will definitely stay here again because of the central location, beautiful rooms and friendliness of the staff. Couldn’t ask for a better experience."

A verified traveler stayed at Hotel Boutique Corral del Rey by ALUZ Collection