Book a hotel near Main Street Hyannis, Hyannis
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Top hotels close to Main Street Hyannis

SeaCoast Inn
33 Ocean Street Hyannis MA
0.09 mi from Main Street Hyannis
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Express check-out and laundry facilities are also provided.
Parking included
Free WiFi

Hyannis Travel Inn
18 North St Hyannis MA
0.15 mi from Main Street Hyannis
This hotel features an outdoor pool and an indoor pool. Enjoy the hot tub and free perks like continental breakfast and free self parking. Free WiFi in public areas, a terrace, and express check-out are also on offer.
Pool
Hot Tub

Heritage House Inn on Cape Cod
540 Old Colony Rd Hyannis MA
0.17 mi from Main Street Hyannis
The motel doesn't skimp on freebies - guests receive free continental breakfast and free self parking. An indoor pool is also provided.
Pool
Breakfast included

Comfort Inn Hyannis - Cape Cod
259 Main Street Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.18 mi from Main Street Hyannis
$98 nightly
The price is $112 total per night
$112 total
Dec 15 - Dec 16
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Pool
Hot Tub

Courtyard Resort
125 North St Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Main Street Hyannis
$109 nightly
The price is $125 total per night
$125 total
Dec 17 - Dec 18
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Business travelers can take advantage of the free WiFi in public areas. Free self parking and a computer station are also offered on site.
Pool
Hot Tub

Ocean Street Inn on Hyannis Harbor
131 Ocean St Hyannis MA
0.26 mi from Main Street Hyannis
Free WiFi in public areas and a terrace are available at this motel.
Free WiFi
Air conditioning

Hyannis Harbor Hotel
213 Ocean St Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.39 mi from Main Street Hyannis
$151 nightly
The price is $173 total per night
$173 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the seasonal outdoor pool and perks like free self parking.
Pool
Hot Tub

Anchor In Distinctive Waterfront Lodging
1 South Street Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.4 mi from Main Street Hyannis
$185 nightly
The price is $211 total per night
$211 total
Dec 21 - Dec 22
Total with taxes and fees
A seasonal outdoor pool, self parking, and concierge services are featured at this hotel. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A terrace, a garden, and a snack bar/deli are also on offer.
Pool
Breakfast included

Hyannis Plaza Hotel
662 Main Street Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.54 mi from Main Street Hyannis
$73 nightly
The price is $84 total per night
$84 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
An outdoor pool is featured at this hotel, along with free self parking. There's a garden and multilingual staff can provide around-the-clock assistance.
Pool
Parking included

Doubletree by Hilton Cape Cod - Hyannis
287 Iyannough Rd Hyannis MA
Free Cancellation
Reserve now, pay when you stay
0.64 mi from Main Street Hyannis
$115 nightly
The price is $131 total per night
$131 total
Dec 26 - Dec 27
Total with taxes and fees
This hotel features 2 restaurants, an indoor pool, and a gym. Enjoy the seasonal outdoor pool and perks like free self parking and free WiFi. You'll appreciate the sauna, bar/lounge, and laundry facilities.
Pool
Parking included

Cape Sands Inn
149 Main St - RT 28 West Yarmouth MA
Free Cancellation
Reserve now, pay when you stay
1.21 mi from Main Street Hyannis
$59 nightly
The price is $68 total per night
$68 total
Dec 12 - Dec 13
Total with taxes and fees
This motel features an indoor pool and a seasonal outdoor pool. There's fun for all ages with a playground and an arcade/game room, and families will appreciate the picnic area. Enjoy the hot tub and perks like free self parking and free WiFi.
Pool
Hot Tub

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
867 Iyannough Road Hyannis MA
Free Cancellation
Reserve now, pay when you stay
1.42 mi from Main Street Hyannis
$101 nightly
The price is $116 total per night
$116 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the free continental breakfast each morning.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Main Street Hyannis
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Main Street Hyannis hotels essential information
Accommodation | 3,510 hotels |
|---|---|
Lowest Price | $68 |
Highest Price | $211 |
Popular hotels | Hyannis Travel Inn, Fairfield Inn & Suites by Marriott Cape Cod Hyannis, Courtyard Resort, Comfort Inn Hyannis - Cape Cod, Hyannis Plaza Hotel, Cape Sands Inn, Anchor In Distinctive Waterfront Lodging, Hyannis Harbor Hotel, Ocean Street Inn on Hyannis Harbor, Heritage House Inn on Cape Cod, SeaCoast Inn, Doubletree by Hilton Cape Cod - Hyannis |
Recent Main Street Hyannis hotel reviews by fellow wanderers

Hyannis Travel Inn
5 out of 5
Posted 12 hours ago
Travelocity Verified Review
"Very kind staff. Functional, clean room. Had an early bus and they let me take a few things for breakfast the night before."
A verified traveler stayed at Hyannis Travel Inn
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