Book Hotels in Irene, SD
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Top Irene hotels

Shady Creek Cabin - Family Friendly Getaway Near Lake
Yankton SD
This cabin features a water park, a garden, and laundry facilities. Barbecue grills are provided for your convenience.
It’s a great cabin, lots of room, in great shape, easy access, wonderful area. Enjoyed the wildlife we saw mornings and nights.
Reviewed on Jan 11, 2026

Fairfield Inn & Suites by Marriott Yankton
508 WEST 21ST STREET Yankton SD
Fully refundableReserve now, pay when you stay
The price is $121 total per night from Jan 25 to Jan 26
$121 total
per night
Jan 25 - Jan 26
An indoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public areas. ...
The room was immaculate!! Beautiful facility and probably the best hotel in Yankton. Very happy!
Reviewed on Jan 2, 2026

Holiday Inn Express & Suites Yankton by IHG
2607 Broadway Ave Yankton SD
Fully refundable
The price is $117 total per night from Jan 26 to Jan 27
$117 total
per night
Jan 26 - Jan 27
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Nice rooms and a wonderful choice of breakfast items!
Reviewed on Jan 15, 2026

Comfort Inn Yankton SD
611 W 23rd Street Yankton SD
Fully refundableReserve now, pay when you stay
The price is $98 total per night from Jan 25 to Jan 26
$98 total
per night
Jan 25 - Jan 26
This hotel features a gym and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies ...
Our room was clean and comfortable. We enjoyed relaxing in the whirlpool.
Reviewed on Jan 12, 2026

Lewis and Clark Resort
43496 Shore Drive Yankton SD
The price is $99 total per night from Jan 19 to Jan 20
$99 total
per night
Jan 19 - Jan 20
A marina and a restaurant are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
Clean, full kitchen
Reviewed on Dec 25, 2025

Best Western Kelly Inn
1607 E Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
The price is $104 total per night from Jan 25 to Jan 26
$104 total
per night
Jan 25 - Jan 26
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Great pool. Kids loved it.
Reviewed on Jan 13, 2026

Yankton Inn
1603 East Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
The price is $92 total per night from Jan 20 to Jan 21
$92 total
per night
Jan 20 - Jan 21
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
Clean room, low pet fee, quiet.
Reviewed on Dec 4, 2025

Econo Lodge Inn & Suites
2410 Broadway Ave Yankton SD
Fully refundableReserve now, pay when you stay
The price is $67 total per night from Jan 25 to Jan 26
$67 total
per night
Jan 25 - Jan 26
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Yes the room was clean staff was great
Reviewed on Dec 18, 2025

Super 8 by Wyndham Beresford
1410 W Cedar St Beresford SD
Fully refundableReserve now, pay when you stay
The price is $68 total per night from Jan 20 to Jan 21
$68 total
per night
Jan 20 - Jan 21
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. Staff at the 24-hour ...
Yes the room was clean. I Feel that the night service check in person could be a little more friendly and helpful. I Stayed here do to incomlant weather so I'm able to be at my job the next day because I live an hour away. I have not used the breakfast because I leave for work at 4 Am
Reviewed on Dec 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Recent Irene hotel reviews by fellow wanderers

Holiday Inn Express & Suites Yankton by IHG
5 out of 5
Posted 4 days ago
Travelocity Verified Review
"Nice rooms and a wonderful choice of breakfast items!"
A verified traveler stayed at Holiday Inn Express & Suites Yankton by IHG
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