Book Hotels in Irene, SD

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility

Top Irene hotels

Beautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD

Beautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD

Yankton SD
This cabin featured laundry facilities and barbecue grills.
"It was a wonderful property about a 5 minute drive to marina. Lots of wildlife. Property was well stocked and clean. Plenty of room for everyone. The one negative was that there is no television in the living room. So if you want to watch a game or movie as a group, there is no larger space with ..."

Reviewed on Aug 6, 2025

Opens in a new windowBeautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD
Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Crofton NE
$950 nightly
The price is $1,050 total per night from Jun 10 to Jun 11
$1,050 total
Jun 10 - Jun 11
Total with taxes and fees
This vacation home includes a garden and laundry facilities.
"Beautiful home plenty, of space, lots of refrigerator room! Great for our big family. Would love to rent it again in the future! My favorite time was sitting on the deck in the evening."

Reviewed on May 10, 2026

Opens in a new windowModern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Holiday Inn Express & Suites Yankton by IHG

Holiday Inn Express & Suites Yankton by IHG

2.5 out of 5
2607 Broadway Ave Yankton SD
Fully refundable
$114 nightly
The price is $126 total per night from Jun 14 to Jun 15
$126 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Front desk staff were so nice! Breakfast was amazing! Cleanest hotel room I’ve stayed in"

Reviewed on Jun 7, 2026

Opens in a new windowHoliday Inn Express & Suites Yankton by IHG
Comfort Inn Yankton SD

Comfort Inn Yankton SD

2.5 out of 5
611 W 23rd Street Yankton SD
Fully refundable
$101 nightly
The price is $112 total per night from Jun 28 to Jun 29
$112 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features a gym and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies ...
"Great property! Very friendly staff!"

Reviewed on Jun 5, 2026

Opens in a new windowComfort Inn Yankton SD
Lewis and Clark Resort

Lewis and Clark Resort

2.5 out of 5
43496 Shore Drive Yankton SD
$114 nightly
The price is $120 total per night from Jun 9 to Jun 10
$120 total
Jun 9 - Jun 10
Total with taxes and fees
A marina and a restaurant are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
"We liked everything they had to offer peaceful walks lake very beautiful would suggest renting cart for ride thru parks enjoyed it very much ! Seen dear in campground had our puppy with us very friendly service!! Will stay there again!!!"

Reviewed on Jun 5, 2026

Opens in a new windowLewis and Clark Resort
Best Western Kelly Inn

Best Western Kelly Inn

2.5 out of 5
1607 E Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Jun 14 to Jun 15
$110 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"The room, especially the bathroom, wasn't clean. We checked in at 11 PM and immediately changed into our pajamas. Had I seen the bathroom prior to that, I would have asked to be moved to another room. We were just too exhausted to address the issue that late in the day."

Reviewed on Jun 6, 2026

Opens in a new windowBest Western Kelly Inn
Super 8 by Wyndham Yankton

Super 8 by Wyndham Yankton

2 out of 5
1603 East Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $94 total per night from Jun 10 to Jun 11
$94 total
Jun 10 - Jun 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
"Helpful staff and clean, but A/C filled the room full of noise trying to keep it cool."

Reviewed on May 29, 2026

Opens in a new windowSuper 8 by Wyndham Yankton
Econo Lodge Inn & Suites Yankton

Econo Lodge Inn & Suites Yankton

2 out of 5
2410 Broadway Ave Yankton SD
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $85 total per night from Jun 10 to Jun 11
$85 total
Jun 10 - Jun 11
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The room was clean. The coffee maker in the room did not work, otherwise overall was a good experience"

Reviewed on Jun 3, 2026

Opens in a new windowEcono Lodge Inn & Suites Yankton
Fairfield Inn & Suites by Marriott Yankton

Fairfield Inn & Suites by Marriott Yankton

3 out of 5
508 WEST 21ST STREET Yankton SD
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $137 total per night from Jun 28 to Jun 29
$137 total
Jun 28 - Jun 29
Total with taxes and fees
An indoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public areas. ...
Opens in a new windowFairfield Inn & Suites by Marriott Yankton
Don't see what you're looking for?
See all available properties in Irene
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Irene?
Family trips are where wonderful memories are made, but it's no secret that traveling with young ones can be demanding. These kid-friendly Irene hotels come with perks that aim to keep visitors of all ages relaxed and happy: Holiday Inn Express & Suites Yankton, an IHG Hotel will help make your trip the most memorable one yet. It comes with a host of conveniences aimed at families, such as a swimming pool and complimentary breakfast. Best Western Kelly Inn is another top place to stay. After a big day of sightseeing, come back home to your comfy room and perks like a swimming pool and a waterslide.
Where can I find cheap hotels in Irene?
At Travelocity you'll find really nice hotels in Irene at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Irene rather than in Irene. We may find you even better rates, too.
How do I find the best Irene hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Irene then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Irene?
The cheapest hotel in Irene is $85. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Irene?
There are 84 hotels in Irene on Travelocity.
What are the best hotels in Irene?
Irene has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Irene for you!
When is the best time to visit Irene?
If you want the joy of a fun-filled trip in peak season, visit Irene during May, August and October. If you'd prefer the peace of off-season, book a stay during quieter months, such as February, November and December.
When is the cheapest time to stay in Irene?
Based on historic data is usually the cheapest month to visit Irene. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Irene?
There are multiple hotels in Irene that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Irene. We have plenty of kid-friendly hotels in Irene to choose from on Travelocity!
Why book a hotel in Irene through Travelocity?
Because we have the top hotels in Irene! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Irene on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Irene hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity