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Top Irene hotels

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Crofton NE
$813 nightly
The price is $898 total per night from Mar 22 to Mar 23
$898 total
Mar 22 - Mar 23
Total with taxes and fees
This vacation home includes a garden and laundry facilities.
Our family had a wonderful time staying in this lovely house. It is so full of light and spacious. We were able to put the littles to bed early on a different floor while the adults played loud games. The ping pong table was great entertainment to keep kids off their phones too! We would stay here ...

Reviewed on Mar 8, 2026

Opens in a new windowModern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Fairfield Inn & Suites by Marriott Yankton

Fairfield Inn & Suites by Marriott Yankton

3 out of 5
508 WEST 21ST STREET Yankton SD
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $137 total per night from Apr 12 to Apr 13
$137 total
Apr 12 - Apr 13
Total with taxes and fees
An indoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public areas. ...
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Reviewed on Mar 9, 2026

Opens in a new windowFairfield Inn & Suites by Marriott Yankton
Comfort Inn Yankton SD

Comfort Inn Yankton SD

2.5 out of 5
611 W 23rd Street Yankton SD
Fully refundable
$88 nightly
The price is $98 total per night from Mar 25 to Mar 26
$98 total
Mar 25 - Mar 26
Total with taxes and fees
This hotel features a gym and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies ...
Had a pleasant stay. It was a clean simple room with all the normal necessities. Just wished the breakfast hours were adjusted a little later for the weekend.

Reviewed on Mar 17, 2026

Opens in a new windowComfort Inn Yankton SD
Lewis and Clark Resort

Lewis and Clark Resort

2.5 out of 5
43496 Shore Drive Yankton SD
$84 nightly
The price is $89 total per night from Mar 22 to Mar 23
$89 total
Mar 22 - Mar 23
Total with taxes and fees
A marina and a restaurant are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
great place to stay! clean rooms with great views! the water and walking path are awesome. Good staff as well!

Reviewed on Mar 16, 2026

Opens in a new windowLewis and Clark Resort
Best Western Kelly Inn

Best Western Kelly Inn

2.5 out of 5
1607 E Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Mar 26 to Mar 27
$109 total
Mar 26 - Mar 27
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Honestly we would not stay here again if we dint really have too. Our room still had a sticker on the t.v from pervious people. That tells me it did not get cleaned very well along with crumbs still on the floor. Our sliding door to the pool the handle was broken so it was hard to open and close. ...

Reviewed on Mar 9, 2026

Opens in a new windowBest Western Kelly Inn
Yankton Inn

Yankton Inn

2 out of 5
1603 East Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $82 total per night from Mar 24 to Mar 25
$82 total
Mar 24 - Mar 25
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
It was good for what I needed

Reviewed on Feb 15, 2026

Opens in a new windowYankton Inn
Econo Lodge Inn & Suites Yankton

Econo Lodge Inn & Suites Yankton

2 out of 5
2410 Broadway Ave Yankton SD
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $76 total per night from Mar 25 to Mar 26
$76 total
Mar 25 - Mar 26
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Clean room and breakfast area

Reviewed on Mar 16, 2026

Opens in a new windowEcono Lodge Inn & Suites Yankton
Super 8 by Wyndham Beresford

Super 8 by Wyndham Beresford

2 out of 5
1410 W Cedar St Beresford SD
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $71 total per night from Apr 3 to Apr 4
$71 total
Apr 3 - Apr 4
Total with taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. Staff at the 24-hour ...
Extremely low budget. Dirty, stained linens. Just bad.

Reviewed on Feb 8, 2026

Opens in a new windowSuper 8 by Wyndham Beresford
Holiday Inn Express & Suites Yankton by IHG

Holiday Inn Express & Suites Yankton by IHG

2.5 out of 5
2607 Broadway Ave Yankton SD
Fully refundable
$110 nightly
The price is $121 total per night from Apr 16 to Apr 17
$121 total
Apr 16 - Apr 17
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Opens in a new windowHoliday Inn Express & Suites Yankton by IHG
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the top kid-friendly hotels in Irene?
Family trips are where wonderful memories are made, but it's no secret that traveling with young ones can be demanding. These kid-friendly Irene hotels come with perks that aim to keep visitors of all ages relaxed and happy: Holiday Inn Express & Suites Yankton, an IHG Hotel will help make your trip the most memorable one yet. It comes with a host of conveniences aimed at families, such as a swimming pool and complimentary breakfast. Best Western Kelly Inn is another top place to stay. After a big day of sightseeing, come back home to your comfy room and perks like a swimming pool and a waterslide.
Where can I find cheap hotels in Irene?
At Travelocity you'll find really nice hotels in Irene at great prices. We source incredible prices with our trusted partners, so you have a tempting selection of cheap hotels to choose from. If you can be flexible on dates and location, consider staying at a hotel near Irene rather than in Irene. We may find you even better rates, too.
How do I find the best Irene hotel deals?
Simple! On Travelocity, look through the fantastic offers we've already found in Irene then use our filters to find a great deal that's perfect for you. Enter your travel dates, select the number of rooms you need, and we'll do the rest. You can get great discounts on flights and car hire, too, when you bundle.
How much does it cost to stay in a hotel in Irene?
The cheapest hotel in Irene is $71. This price was available within the past 7 days, for stays with a check-in date within the next year. Of course, the price you pay depends on your dates of travel, the length of your stay, and the hotel's location. Prices and availability are subject to change. Additional terms apply.
How many hotels are in Irene?
There are 83 hotels in Irene on Travelocity.
What are the best hotels in Irene?
Irene has so many great hotels to choose from at Travelocity — and it's so easy to find the perfect one. Just choose one of our popular pre-selected hotels with great reviews, or you can refine your search to build your ideal stay. Simply filter hotels based on price or star rating, or select properties with a pool, a hot tub, or a range of other amenities and pick the best place to stay in Irene for you!
When is the best time to visit Irene?
If you want the joy of a fun-filled trip in peak season, visit Irene during May, August and October. If you'd prefer the peace of off-season, book a stay during quieter months, such as February, November and December.
When is the cheapest time to stay in Irene?
Based on historic data is usually the cheapest month to visit Irene. However, we have incredible deals all year round, so we're confident you'll find a room in your budget whenever you choose to travel.
Are there any great family-friendly hotels in Irene?
There are multiple hotels in Irene that will please the whole family. Do you need adjoining rooms, babysitting services or a swimming pool? We've got you covered. Use our family filter to narrow your search down and use guest reviews to help you pick the perfect place for your next family trip to Irene. We have plenty of kid-friendly hotels in Irene to choose from on Travelocity!
Why book a hotel in Irene through Travelocity?
Because we have the top hotels in Irene! We want to help you travel more and worry less. That's why we've put the most amazing hotel, car rental, and flight deals in one place. When you search for hotels with us, you know you're getting fantastic prices with no hidden fees and free cancellation on most properties up to 24 hours before your stay. If you become a Travelocity member, you also get exclusive member discounts. Sign up today!
How do I cancel my hotel booking in Irene on Travelocity?
Canceling your booking with Travelocity is easy. Sign into your account and select My Trips. Here, you will see your cancellation options. We offer free cancellation on many properties.

Recent Irene hotel reviews by fellow wanderers

Comfort Inn Yankton SD

Comfort Inn Yankton SD

4 out of 5
Posted 2 days ago
Travelocity Verified Review
"Had a pleasant stay. It was a clean simple room with all the normal necessities. Just wished the breakfast hours were adjusted a little later for the weekend. "
A verified traveler stayed at Comfort Inn Yankton SD
Comfort Inn Yankton SD

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