Book Hotels in Irene, SD
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Top Irene hotels

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Crofton NE
$808 nightly
The price is $893 total per night from Mar 5 to Mar 6
$893 total
Mar 5 - Mar 6
Total with taxes and fees
This vacation home includes a garden and laundry facilities.
Super clean and everything was ready for us plenty of room for 10 of us to enjoy together
Reviewed on Jan 6, 2026

Fairfield Inn & Suites by Marriott Yankton
508 WEST 21ST STREET Yankton SD
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $137 total per night from Mar 15 to Mar 16
$137 total
Mar 15 - Mar 16
Total with taxes and fees
An indoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public areas. ...
The property was well lit and in excellent condition. The staff was very helpful!
Reviewed on Feb 23, 2026

Comfort Inn Yankton SD
611 W 23rd Street Yankton SD
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $107 total per night from Mar 26 to Mar 27
$107 total
Mar 26 - Mar 27
Total with taxes and fees
This hotel features a gym and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies ...
Friendly staff, clean room.
Reviewed on Feb 28, 2026

Lewis and Clark Resort
43496 Shore Drive Yankton SD
$84 nightly
The price is $89 total per night from Mar 8 to Mar 9
$89 total
Mar 8 - Mar 9
Total with taxes and fees
A marina and a restaurant are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
Perfect spot!
Reviewed on Mar 3, 2026

Best Western Kelly Inn
1607 E Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $106 total per night from Mar 5 to Mar 6
$106 total
Mar 5 - Mar 6
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
Everything was pretty good, but the 2nd night was crazy. We didn’t get to bed until midnight, kids were running in the hallway and screaming.
Reviewed on Feb 22, 2026

Yankton Inn
1603 East Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $82 total per night from Mar 10 to Mar 11
$82 total
Mar 10 - Mar 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
It was good for what I needed
Reviewed on Feb 15, 2026

Econo Lodge Inn & Suites Yankton
2410 Broadway Ave Yankton SD
Fully refundableReserve now, pay when you stay
$64 nightly
The price is $71 total per night from Mar 10 to Mar 11
$71 total
Mar 10 - Mar 11
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
Good hotel. Clean room, good breakfast, and good rate.
Reviewed on Mar 3, 2026

Super 8 by Wyndham Beresford
1410 W Cedar St Beresford SD
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $74 total per night from Mar 8 to Mar 9
$74 total
Mar 8 - Mar 9
Total with taxes and fees
This motel features free WiFi in public areas, laundry facilities, and free self parking. Enjoy the free on-the-go breakfast each morning. Staff at the 24-hour ...
Extremely low budget. Dirty, stained linens. Just bad.
Reviewed on Feb 8, 2026

Holiday Inn Express & Suites Yankton by IHG
2607 Broadway Ave Yankton SD
Fully refundable
$106 nightly
The price is $117 total per night from Apr 2 to Apr 3
$117 total
Apr 2 - Apr 3
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Irene hotel reviews by fellow wanderers

Fairfield Inn & Suites by Marriott Yankton
5 out of 5
Posted 8 days ago
Travelocity Verified Review
"The property was well lit and in excellent condition. The staff was very helpful!"
A verified traveler stayed at Fairfield Inn & Suites by Marriott Yankton
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