Book Hotels in Irene, SD
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Top Irene hotels

Beautiful log cabin, only 1.7 miles from lake dock by Lewis & Clark, Yankton SD
Yankton SD
This cabin featured laundry facilities and barbecue grills.
"It was a wonderful property about a 5 minute drive to marina. Lots of wildlife. Property was well stocked and clean. Plenty of room for everyone. The one negative was that there is no television in the living room. So if you want to watch a game or movie as a group, there is no larger space with ..."
Reviewed on Aug 6, 2025

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Crofton NE
$950 nightly
The price is $1,050 total per night from Jun 10 to Jun 11
$1,050 total
Jun 10 - Jun 11
Total with taxes and fees
This vacation home includes a garden and laundry facilities.
"Beautiful home plenty, of space, lots of refrigerator room! Great for our big family. Would love to rent it again in the future! My favorite time was sitting on the deck in the evening."
Reviewed on May 10, 2026

Holiday Inn Express & Suites Yankton by IHG
2607 Broadway Ave Yankton SD
Fully refundable
$114 nightly
The price is $126 total per night from Jun 14 to Jun 15
$126 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features an indoor pool and a gym. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the hot tub and ...
"Front desk staff were so nice! Breakfast was amazing! Cleanest hotel room I’ve stayed in"
Reviewed on Jun 7, 2026

Comfort Inn Yankton SD
611 W 23rd Street Yankton SD
Fully refundable
$101 nightly
The price is $112 total per night from Jun 28 to Jun 29
$112 total
Jun 28 - Jun 29
Total with taxes and fees
This hotel features a gym and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies ...
"Great property! Very friendly staff!"
Reviewed on Jun 5, 2026

Lewis and Clark Resort
43496 Shore Drive Yankton SD
$114 nightly
The price is $120 total per night from Jun 9 to Jun 10
$120 total
Jun 9 - Jun 10
Total with taxes and fees
A marina and a restaurant are featured at this hotel. Traveling on business? Take advantage of the free WiFi in public areas, conference center, and conference ...
"We liked everything they had to offer peaceful walks lake very beautiful would suggest renting cart for ride thru parks enjoyed it very much ! Seen dear in campground had our puppy with us very friendly service!! Will stay there again!!!"
Reviewed on Jun 5, 2026

Best Western Kelly Inn
1607 E Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $110 total per night from Jun 14 to Jun 15
$110 total
Jun 14 - Jun 15
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public ...
"The room, especially the bathroom, wasn't clean. We checked in at 11 PM and immediately changed into our pajamas. Had I seen the bathroom prior to that, I would have asked to be moved to another room. We were just too exhausted to address the issue that late in the day."
Reviewed on Jun 6, 2026

Super 8 by Wyndham Yankton
1603 East Highway 50 Yankton SD
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $94 total per night from Jun 10 to Jun 11
$94 total
Jun 10 - Jun 11
Total with taxes and fees
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Staff at the 24-hour front desk can provide ...
"Helpful staff and clean, but A/C filled the room full of noise trying to keep it cool."
Reviewed on May 29, 2026

Econo Lodge Inn & Suites Yankton
2410 Broadway Ave Yankton SD
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $85 total per night from Jun 10 to Jun 11
$85 total
Jun 10 - Jun 11
Total with taxes and fees
This hotel features an indoor pool and a hot tub. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate ...
"The room was clean. The coffee maker in the room did not work, otherwise overall was a good experience"
Reviewed on Jun 3, 2026

Fairfield Inn & Suites by Marriott Yankton
508 WEST 21ST STREET Yankton SD
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $137 total per night from Jun 28 to Jun 29
$137 total
Jun 28 - Jun 29
Total with taxes and fees
An indoor pool is featured at this hotel, along with free self parking. Guests will appreciate free perks like continental breakfast and WiFi in public areas. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent Irene hotel reviews by fellow wanderers

Holiday Inn Express & Suites Yankton by IHG
5 out of 5
Posted 22 hours ago
Travelocity Verified Review
"Front desk staff were so nice! Breakfast was amazing! Cleanest hotel room I’ve stayed in"
A verified traveler stayed at Holiday Inn Express & Suites Yankton by IHG
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