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Popular South America Cruise Deals

See all 309 cruises to South America

Cruises to South America

What’s there to see at the top South American cruise destinations?

  • Unique Wildlife: If you’ve always wanted to see a penguin up close, then both Punta Arenas and the Falkland Islands have these well-dressed birds roaming the surrounding beaches, as well as elephant seals and Commerson’s dolphins. Beyond the wildlife, both areas boast unspoiled majestic beauty. Off the coast of Ecuador, the Galapagos Islands are also worth a look. Besides the famed giant tortoises, the rich marine life (including sea iguanas) surrounding the islands is a must-see for any diver.
  • One-of-a Kind Cities: Experience the natural and cultural diversity of South America. A port of call in Buenos Aires introduces you to a city of old-world European charm fused with a vibrant Latin culture and an incredible food scene famous for succulent steaks. Rio de Janeiro’s golden beaches and lush mountains frame a city brimming with activity day and night. Once you round Cape Horn, you may stop in Tierra del Fuego. The town of Ushuaia offers travelers a welcoming basecamp to recharge after they have explored these windswept lands at world’s end.

Which South America cruise line is right for me? 

  • MSC Cruises: This Swiss-based cruise line strives for a more refined cruising experience. You won’t find a lot of glitz on these ships, but simple elegance and eclectic amenities like adults-only pools, as well as spas and 4D cinemas. While the line doesn’t specifically cater to kids, those that are 11 years and younger sail for free.
  • CostaThe largest cruise line in Europe offers an Italian-style experience: the food, shows, décor, and festive atmosphere are Mediterranean-inspired. This line aims to give passengers a memorable experience off the ship as well, and provides numerous shore excursions.
  • Princess Cruises: This line caters to families and couples seeking a competitively priced and relaxed cruise. They have supervised activities for children like science centers and movie nights, and offer both assigned and unassigned dining experiences.

Cheap Flights

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Cheap Hotels

Estimated price for 1 night/2 adults

Rochester Classic

Rochester Classic

Esmeralda 542, Buenos Aires, Capital Federal
  • Free Cancellation
3.5 out of 5.0

Located in the heart of Buenos Aires, this elegant hotel is 2 blocks from Florida Street shopping, dining, and entertainment.

Rochester Classic$52

when booking May 15 - May 16

Regal Pacific Buenos Aires

Regal Pacific Buenos Aires

25 De Mayo, 764, Buenos Aires, Capital Federal
  • Free Cancellation
  • Reserve now, pay when you stay
4.5 out of 5.0

Regal Pacific Buenos Aires is a 5-minute walk from the gleaming high-rises and posh steakhouses lining the Puerto Madero waterfront. Guests can shop for tango ...

Regal Pacific Buenos Aires$115

when booking May 10 - May 11

Almacruz Hotel y Centro de Convenciones (Ex Galerías)

Almacruz Hotel y Centro de Convenciones (Ex Galerías)

San Antonio 65, Santiago, Region Metropolitana
  • Free Cancellation
  • Reserve now, pay when you stay
4.0 out of 5.0

Located in Santiago Center, this hotel is within a 10-minute walk of San Francisco Church, University of Chile, and Plaza de Armas. Palacio de la Moneda and ...

Almacruz Hotel y Centro de Convenciones (Ex Galerías)$87

when booking May 2 - May 3

Argentina Tango Hotel

Argentina Tango Hotel

Suipacha 545, Buenos Aires, Capital Federal
  • Free Cancellation
  • Reserve now, pay when you stay
3.0 out of 5.0

Located in El Centro, this hotel is within a 5-minute walk of Lavalle Street and Teatro Colon. Obelisco and Florida Street are also within 10 minutes. Lavalle ...

Argentina Tango Hotel$35

when booking May 3 - May 4

*Prices are cruise only, per person, double occupancy. Taxes, fees and port expenses not included. Rates are valid for US and Canadian residents only. Fuel supplement may apply. Savings advertised and Expedia Extras are based on specific cabin types and sailing dates, and may not be available for all cabin types/sailings.